Abstract
Objective: 1) Estimate the incidence-rate of juvenile-RRP (JoRRP) and adult-RRP (AoRRP) for each year between 1987 to 2009 in a Norwegian subpopulation. 2) The incidence of HPV-induced genital-HPV infections and oropharyngeal cancer in Western countries is increasing. This study was conducted to investigate whether there are similar trends in RRP.
Method: Population-based epidemiological survey. Two Norwegian subpopulations, with 2.5 million and 1.1 million inhabitants, were investigated for JoRRP and AoRRP respectively. RRP-patients in all ENT-departments located in the 2 areas were identified. The estimates are based on data from the Norwegian Census Bureau during the time-period.
Results: Median age at onset was 34 years (interquartile range, 15) for AoRRP and 4 years (interquartile range, 5) for JoRRP. Concerning age at onset there was neither significant differences between genders, nor significant changes during the time-period. The overall incidence-rates in juveniles and adults were 0.17 (95% CI = 0.44-0.65) and 0.54 (95%CI=0.10-0.25) per 100 000 respectively. We could show a male preponderance in both groups. (P = .000 for AoRRP and P = .038 for JoRRP) There was no significant change of the incidence-rate during the time period neither for AoRRP nor JoRRP or when stratified for gender in each group.
Conclusion: This study does not support our hypothesis of an increasing incidence neither for JoRRP nor for AoRRP. The estimated incidence-rates in the Norwegian subpopulations are consistent with former population based epidemiological surveys. Male preponderance in JoRRP was an unexpected finding. Further surveys are warranted.
Get full access to this article
View all access options for this article.