Physician and nurse researchers, Institutional Review Board members, and parents of children with HIV were asked, during interviews, to describe their views on the ethical issues involved in the conduct of clinical drug research that uses as subjects children who are seropositive for HIV Twenty-eight interviews atfour clinical sites were completed Two significant ethical topic issues were identified. The study presents and analyzes, using bioethical perspectives, () factors that affect access of seropositive children to care and (2) concerns that the respondents presented about the amount of risk appropriate for the afflicted children.
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References
1.
Ackerman, T. (1979). Fooling ourselves with child autonomy and nontherapeutic clinical research. Clinical Research, 27(5), 345-348.
2.
Ackerman, T. (1990). Protectionism and the new research imperative in pediatric AIDS. Institutional Review Board, 12(5), 1-5.
3.
Beauchamp, T. , & Childress, J. (1989). Principles of biomedical ethics (3rd ed.). New York: Oxford University Press.
4.
Benner, P. , & Wrubel, J. (1989). The primacy of caring: Stress and coping in illness. New York: Addison-Wesley.
5.
Cooper, C. (1991). Principle-oriented ethics and the ethic of care: A creative tension. Advances in Nursing Science, 14(2), 22-31.
6.
Department of Health and Human Services . (1983, March 8). Additional protections for children involved in research. Federal Register, 48(46), 46.401-46.409.
Kopelman, L. (1989). When is the risk minimal enough for children to be research subjects? In L. Kopelman & J. Moskop (Eds.), Children and health care: Moral and social issues (pp. 89-99). Dordrecht, The Netherlands: Kluwer.
9.
Levine, R. (1989). Children as research subjects. In L. Kopelman & J. Moskop (Eds.), Children and health care: Moral and social issues (pp. 73-87). Dordrecht, The Netherlands: Kluwer.
10.
McCartney, J. (1978). Research on children: The National Commission says "yes, if. Hastings Center Report, 8(5), 26-31.
11.
Meslin, E. (1990). Protecting human subjects from harm through improved risk judgements. Institutional Review Board, 12(1), 7-10.
12.
National Commission for the Protection of Human Subjects of Biological and Behavioral Research . (1977). Research involving children: Report and recommendations (DHEW Pub. (OS)77-0004, Appendix, DHEW Pub. (OS)77-0005). Washington, DC: U.S. Government Printing Office.
13.
Noddings, N. (1984). Caring: A feminine approach to ethics and moral education. Berkeley: University of California Press.
14.
Ramsey, P. (1970). The patient as person. New Haven, CT: Yale University Press.
