Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high breast cancer risk were randomized to control (n = 7) or intervention (n = 6) and analyzed for sex hormone levels. Serum and urine hormones were evaluated by ultra performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) and sex hormone binding globulin (SHBG) by enzyme-linked immunosorbent assay (ELISA). Serum estrone (E1) and estradiol (E2) were reduced by 12.1% and 50.8%, respectively, at 9 months in the intervention group, which differed from controls (p = .043 and .020). This contrasted with a 73.3% increase in urine E1 at 6 months in the intervention group (p = .035). These results suggest that a lifestyle intervention led to a favorable estrogen profile in relation to breast cancer risk.
BanduraA. (1986). Social foundations of thought and action: A social cognitive theory. Rockville MD: Prentice Hall.
2.
BanduraA. (2011). Social cognitive theory. In van LangeP. A. M.KruglanskiA. W.HigginsE. T. (Eds.), Handbook of social psychological theories (pp. 349-373). London, England: Sage.
3.
CampbellK. L.Foster-SchubertK. E.AlfanoC. M.WangC. C.WangC. Y.DugganC. R.. . . McTiernanA. (2012). Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: Randomized controlled trial. Journal of Clinical Oncology, 30, 2314-2326. doi:10.1200/JCO.2011.37.9792
4.
DallalC. M.BrintonL. A.MatthewsC. E.PfeifferR. M.HartmanT. J.LissowskaJ.. . . GierachG. L. (2016). Association of active and sedentary behaviors with postmenopausal estrogen metabolism. Medicine & Science in Sports & Exercise, 48, 439-448. doi:10.1249/MSS.0000000000000790
5.
DeSantisC. E.FedewaS. A.SauerA. G.KramerJ. L.SmithR. A.JemalA. (2016). Breast cancer statistics, 2015: Convergence of incidence rates between Black and White women. CA: A Cancer Journal for Clinicians, 66(1), 31-42. doi:10.3322/caac.21320
6.
Ellingjord-DaleM.VosL.HjerkindK. V.HjartåkerA.RussnesH. G.TretliS.. . . UrsinG. (2018). Number of risky lifestyle behaviors and breast cancer risk. JNCI Cancer Spectrum, 2(3), Article pky030. doi:10.1093/jncics/pky030
7.
Ennour-IdrissiK.MaunsellE.DiorioC. (2015). Effect of physical activity on sex hormones in women: A systematic review and meta-analysis of randomized controlled trials. Breast Cancer Research, 17(1), Article 139. doi:10.1186/s13058-015-0647-3
8.
HanC. J.KordeL. A.RedingS.AllottK.Van DorenM.SchwarzY.. . . RedingK. W. (2018). Investigation of a lifestyle intervention in women at high risk of breast cancer. Western Journal of Nursing Research, 40, 976-996. doi:10.1177/0193945917697227
9.
KamińskaM.CiszewskiT.Łopacka-SzatanK.MiotłaP.StarosławskaE. (2015). Breast cancer risk factors. Menopause Review, 14, 196-202. doi:10.5114/pm.2015.54346
10.
KeyT.ApplebyP.BarnesI.ReevesG. (2002). Endogenous sex hormones and breast cancer in postmenopausal women: Reanalysis of nine prospective studies. Journal of the National Cancer Institute, 94, 606-616. doi:10.1093/jnci/94.8.606
11.
MaskarinecG.BeckfordF.MorimotoY.FrankeA. A.StanczykF. Z. (2015). Association of estrogen measurements in serum and urine of premenopausal women. Biomarkers in Medicine, 9, 417-424. doi:10.2217/bmm.15.10
12.
McTiernanA. (2003). Behavioral risk factors in breast cancer: Can risk be modified?The Oncologist, 8, 326-334. doi:10.1634/theoncologist.8-4-326
13.
RoseD. P.Vona-DavisL. (2014). Biochemical and molecular mechanisms for the association between obesity, chronic inflammation, and breast cancer. Biofactors, 40, 1-12. doi:10.1002/biof.1109
14.
SchmitzK. H.WilliamsN. I.KontosD.DomchekS.MoralesK. H.HwangW. T.. . . GoodJ. (2015). Dose-response effects of aerobic exercise on estrogen among women at high risk for breast cancer: A randomized controlled trial. Breast Cancer Research and Treatment, 154, 309-318. doi:10.1007/s10549-015-3604-z
15.
SiegelR. L.MillerK. D.JemalA. (2018). Cancer statistics, 2018. CA: A Cancer Journal for Clinicians, 68(1), 7-30. doi:10.3322/caac.21442
16.
Stolzenberg-SolomonR. Z.FalkR. T.StanczykF.HooverR. N.AppelL. J.ArdJ. D.. . . KatkiH. A. (2012). Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women. Breast Cancer Research, 14(5), R141. doi:10.1186/bcr3346
17.
TehardB.FriedenreichC. M.OppertJ. M.Clavel-ChapelonF. (2006). Effect of physical activity on women at increased risk of breast cancer: Results from the E3N cohort study. Cancer Epidemiology, Biomarkers and Prevention, 15, 57-64. doi:10.1158/1055-9965.EPI-05-0603
18.
ThomsonC. A.McCulloughM. L.WertheimB. C.ChlebowskiR. T.MartinezM. E.StefanickM. L.. . . NeuhouserM. L. (2014). Nutrition and physical activity cancer prevention guidelines, cancer risk, and mortality in the Women’s Health Initiative. Cancer Prevention Research, 7(1), 42-53. doi:10.1158/1940-6207.CAPR-13-0258
19.
WolinK. Y.ColditzG. A. (2008). Can weight loss prevent cancer?British Journal of Cancer, 99, 995-999. doi:10.1038/sj.bjc.6604623
20.
WoolcottC. G.ShvetsovY. B.StanczykF. Z.WilkensL. R.HendersonB. E.Le MarchandL.. . . GoodmanM. T. (2010). Plasma sex hormone concentrations and breast cancer risk in an ethnically diverse population of postmenopausal women: The Multiethnic Cohort Study. Endocrine-Related Cancer, 17, 125-134. doi:10.1677/ERC-09-0211
21.
World Cancer Research Fund International. (2018). Cancer preventability estimates for diet, nutrition, body fatness, and physical activity. Retrieved from http://www.wcrf.org/cancer-preventability-estimates
