Affecting Cognition and Quality of Life via Aerobic Exercise in Alzheimer’s Disease

Abstract

Aerobic exercise is a promising behavioral therapy for Alzheimer’s disease (AD), yet few studies have investigated the effect of aerobic exercise on cognition in AD. The purpose of this pilot study was to examine the effect of 6-month aerobic exercise on the change in executive function, global cognition, quality of life (QOL), and depression in community-dwelling older adults with mild to moderate AD. A single group, repeated measures design with outcomes measured at baseline, 3 months, and 6 months was used. Results show that there were no significant changes in any measures except for depression (p = .026). There was a trend toward improvement in executive function and QOL with moderate effect sizes (ESs) and a trend toward deterioration in global cognition with moderate to large ESs. Randomized controlled trials are needed to evaluate the therapeutic effect of aerobic exercise in older adults with AD.

Keywords

exercise cognition quality of life dementia aging

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References

Adlard

A. P.

Perreau

V. M.

Pop

Cotman

C. W.

(2004). Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer’s disease. Journal of Neuroscience, 25, 4217-4221.

Alzheimer’s Association. (2011). 2011 Alzheimer’s facts and figures. Retrieved from http://www.alz.org/downloads/Facts_Figures_2011.pdf

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.

Angevaren

Aufdemkampe

Verhaar

H. J.

Aleman

Vanhees

(2008). Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database of Systematic Reviews, 2, CD005381.

Arkin

S. M.

(2001). Alzheimer rehabilitation by students: Interventions and outcomes. Neuropsychological Rehabilitation, 11, 273-317.

Baker

L. D.

Frank

L. L.

Foster-Schubert

Green

P. S.

Wilkinson

C. W.

McTiernan

. . .Craft

(2010). Effects of aerobic exercise on mild cognitive impairment: A controlled trial. Archives of Neurology, 67, 71-79.

Burns

J. M.

Mayo

M. S.

Anderson

H. S.

Smith

H. J.

Donnelly

J. E.

(2008). Cardiorespiratory fitness in early-stage Alzheimer disease. Alzheimer Disease & Associated Disorders, 22, 39-46.

Cohen

Erlbaum

(1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Lawrence Erlbaum.

Colcombe

Kramer

A. F.

(2003). Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychological Science, 14, 125-130.

10.

Cotman

C. W.

Berchtold

N. C.

(2007). Physical activity and the maintenance of cognition: Learning from animal models. Alzheimer’s & Dementia, 3, S30-S37.

11.

Erickson

K. I.

Kramer

A. F.

(2009). Aerobic exercise effects on cognitive and neural plasticity in older adults. British Journal of Sports Medicine, 43, 22-24.

12.

Etnier

J. L.

Nowell

P. M.

Landers

D. M.

Sibley

B. A.

(2006). A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Research Reviews, 52, 119-130.

13.

Etnier

Salazar

Landers

Petruzzello

Han

Nowell

(1997). The influence of physical fitness and exercise upon cognitive functioning: A meta-analysis. Journal of Sport and Exercise Psychology, 19, 249-277.

14.

Folstein

M. F.

Folstein

S. E.

McHugh

P. R.

(1975). “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.

15.

Hawkins

Wiswell

(2003). Rate and mechanism of maximal oxygen consumption decline with aging: Implications for exercise training. Sports Medicine, 33, 877-888.

16.

Heyn

Abreu

B. C.

Ottenbacher

K. J.

(2004). The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis. Archives of Physical Medicine and Rehabilitation, 85, 1694-1704.

17.

Hollenberg

Yang

Haight

T. J.

Tager

I. B.

(2006). Longitudinal changes in aerobic capacity: Implications for concepts of aging. Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 61, 851-858.

18.

Kemoun

Thibaud

Roumagne

Carette

Albinet

Toussaint

. . .Dugué

(2010). Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dementia and Geriatric Cognitive Disorders, 29, 109-114.

19.

Lautenschlager

N. T.

Cox

K. L.

Flicker

Foster

J. K.

van Bockxmeer

F. M.

Xiao

. . .Almeida

O. P.

(2008). Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial. Journal of the American Medical Association, 300, 1027-1037.

20.

Logsdon

R. G.

Gibbons

L. E.

McCurry

S. M.

Teri

(2002). Assessing quality of life in older adults with cognitive impairment. Psychosomatic Medicine, 64, 510-519.

21.

Mitrushina

Drebing

Uchiyama

Satz

Van Gorp

Chervinsky

(1994). The pattern of deficit in different memory components in normal aging and dementia of Alzheimer’s type. Journal of Clinical Psychology, 50, 591-596.

22.

Palleschi

Vetta

De Gennaro

Idone

Scottosanti

Gianni

Marigliano

(1996). Effect of aerobic training on the cognitive performance of elderly patients with senile dementia of Alzheimer type. Archives of Gerontology and Geriatrics, 5, 47-50.

23.

Qiu

Kivipelto

von Strauss

(2009). Epidemiology of Alzheimer’s disease: Occurrence, determinants, and strategies toward intervention. Dialogues in Clinical Neuroscience, 11, 111-128.

24.

Rolland

Rival

Pillard

Lafont

C. H.

Riviere

Albarede

J. L.

Vellas

(2000). Feasibility of regular physical exercise for patients with moderate to severe Alzheimer disease. Journal of Nutrition, Health & Aging, 4, 109-113.

25.

Rosen

W. G.

Mohs

R. C.

Davis

K. L.

(1984). A new rating scale for Alzheimer’s disease. American Journal of Psychiatry, 141, 1356-1364.

26.

Ross

T. P.

(2003). The reliability of cluster and switch scores for the controlled oral word association test. Archives of Clinical Neuropsychology, 18, 153-164.

27.

Royall

D. R.

Chiodo

L. K.

Polk

M. J.

(2003). Executive dyscontrol in normal aging: Normative data, factor structure, and clinical correlates. Current Neurology and Neuroscience Reports, 3, 487-493.

28.

Scarmeas

Luchsinger

J. A.

Schupf

Brickman

A. M.

Cosentino

Tang

M. X.

Stern

(2009). Physical activity, diet, and risk of Alzheimer disease. Journal of the American Medical Association, 302, 627-637.

29.

Scherder

Van Paasschen

Deijen

Van Der Knokke

Orlebeke

Burgers

. . .Sergeant

J. A.

(2005). Physical activity and executive functions in the elderly with mild cognitive impairment. Aging & Mental Health, 9, 272-280.

30.

Sheikh

Yesavage

(1986). Geriatric depression scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontologist, 5, 165-173.

31.

Smith

Blumenthal

Hoffman

Cooper

Strauman

Welsh-Bohmer

. . .Sherwood

(2010). Aerobic exercise and neurocognitive performance: A meta-analytic review of randomized controlled trials. Psychosomatic Medicine, 72, 239-252.

32.

Steinberg

Leoutsakos

J. S.

Podewils

L. J.

Lyketsos

(2009). Evaluation of home-based exercise program in the treatment of Alzheimer’s disease: The maximizing independence in dementia (MIND) study. International Journal of Geriatric Psychiatry, 24, 680-685.

33.

Stroop

J. R.

(1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643-662.

34.

Teri

Gibbons

L. E.

McCurry

S. M.

Logsdon

R. G.

Buchner

D. M.

Barlow

W. E.

. . .Larson

E. B.

(2003). Exercise plus behavioral management in patients with Alzheimer disease: A randomized controlled trial. Journal of the American Medical Association, 290, 2015-2022.

35.

van Uffelen

J. G. Z.

Chinapaw

M. J. M.

van Mechelen

Hopman-Rock

(2008). Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial. British Journal of Sports Medicine, 42, 344-351.

36.

Vogel

Brechat

P. H.

Lepretre

P. M.

Kaltenbach

Berthel

Lonsdorfer

(2009). Health benefits of physical activity in older patients: A review. International Journal of Clinical Practice, 63, 303-320.

37.

(2011). Guiding research and practice: A conceptual model for aerobic exercise training in Alzheimer’s disease. American Journal of Alzheimer’s Disease and Other Dementias, 26, 184-194.

38.

Kolanowski

Strumpf

Eslinger

(2006). Improving cognition and function through exercise intervention in Alzheimer’s disease. Journal of Nursing Scholarship, 38, 358-365.

39.

Savik

Wyman

Bronas

(2011). Maintaining physical fitness and physical function in Alzheimer’s disease: A pilot study. American Journal of Alzheimer’s Disease and Other Dementias. Advance online publication. doi:10.1177/1533317511414861