Commentary: Role of the Pathologist in the Identification and Characterization of Therapeutic Molecules

Baron WF , Pan CQ , Spencer SA , Ryan AM , Lazarus RA , and Baker KP (1998). Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene 215: 291-301.

Cacalano G. , Farinas I. , Wang LC , Hagler K. , Forgie A. , Moore M. , Armanini M. , Phillips H. , Ryan AM , Reichardt LF , Hynes M. , Davies A. , and Rosenthal A. (1998). GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21: 53-62.

Cacalano G. , Lee J. , Kikly K. , Ryan AM , Pitts-Meek S. , Hultgren B. , Wood WI , and Moore MW (1994). Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265: 682-684.

Carpenter D. , Stone DM , Brush J. , Ryan AM , Armanini M. , Frantz G. , Rosenthal A. , and de Sauvage FJ (1998). Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. USA 95: 13630-13634.

deSauvage FJ , Carver-Moore K. , Luoh S-M. , Ryan AM , Dowd M. , Eaton D. , and Moore MW (1996). Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183: 651-656.

Fong S. , Jones S. , Renz ME , Chiu HH , Ryan AM , Presta LD , and Jackson D. (1997). Mucosal addressin cell adhesion molecule-1 (MadCAM-1)—Its binding motif for α4β7 and role in experimental colitis. Immunol. Res. 16: 299-311.

Fox JA , Reitz B. , Hagler K. , Hsei V. , Keller G. , Ryan AM , Schoenhoff MB , and Widmer R. (1997). Pharmacokinetics and clearance mechanisms of anti-IgE:IgE monoclonal and polyclonal complexes. Pharm. Res. 14: S217 (abstract).

Gerber HP , Hillan KJ , Ryan AM , Kowalski J. , Keller G-A. , Rangell L. , Wright BD , Radtke F. , Aguet M. , and Ferrara N. (1999). VEGF is required for growth and survival in neonatal mice. Development 126: 1149-1159.

Grupe A. , Hultgren B. , Ryan AM , Ma YH , and Stewart TA (1995). Transgenic knockouts reveal a critical requirement for beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78.

Hillan KJ , Hagler KE , MacSween Rnm , Ryan AM , Renz ME , Chiu HH , Ferrier RK , Bird GL , Dhillon AP , Ferrel LD , and Fong S. (1999). Expression of the mucosal vascular addressin MAdCAM-1 in inflammatory liver disease. Liver (in press).

Jin H. , Yang R. , Keller G. , Ryan AM , Ko A. , Pennica D. , Wood WI , and Paoni NF (1996). In vivo effects of cardiotrophin-1. Cytokine 8: 920-926.

Kimson PR , De Guzman GG , Keyt BA , Ryan AM , Keyt LK , Shen BQ , and Zioncheck TF (1998). Role of the heparin binding domain in the clearance and localization of vascular endothelial growth factor. J. Am. Coll. Cardiol. 31: 461A (abstract).

Kimson PR , De Guzman GG , Keyt BA , Ryan AM , Keyt LK , and Zioncheck TF (1997). The heparin binding domain of vascular endothelial growth factor governs plasma clearance and tissue localization. Pharm. Res. 14: S366 (abstract).

Lew MA , Brown LA , Sehl PD , Ryan AM , Hillan KJ , and Lowe DG (1998). CARP expression in cardiac injury in the rat. FASEB J. 12: A709 (abstract).

Lu H. , Jin H. , Yang R. , Ogasawara A. , Ryan AM , and Paoni NF (1999). Effects of growth hormone on gene expression in the normal and post-infarct rat heart. Circulation (in press).

Moore MW , Klein RD , Farinas I. , Sauer H. , Armanini M. , Phillips H. , Reichardt LF , Ryan AM , Carver-Moore K. , and Rosenthal A. (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382: 76-79.

Mordenti J. , Cuthbertson RA , Ferrara N. , Thomsen K. , Berleau L. , Licko V. , Allen PC , Valverde CR , Meng YG , Fei Dtw , Fourre KM , and Ryan AM (1999). Comparison of the intraocular tissue distribution, pharmacokinetics and safety of 125I-labeled full length and Fab antibodies in Rhesus monkeys following intravitreal administration . Toxicol. Pathol. (in press).

Mordenti J. , Licko V. , Thomsen K. , Kahn J. , Cuthbertson RA , Duenas E. , Ryan AM , Schofield C. , Berger T. , Meng G. , and Cleland J. (1999). Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or PLGA microsphere formulation. Toxicol. Sci. (in press).

Osaka G. , Carey K. , Cuthbertson A. , Godowski P. , Patapoff T. , Ryan A. , Gadek T. , and Mordenti J. (1996). Pharmacokinetics, tissue distribution and expression efficiency of plasmid [33P] DNA following intravenous administration of DNA/cationic lipid complexes in mice: Use of a novel radionucleotide approach. J. Pharm. Sci. 85: 612-618.

Roos F. , Ryan AM , Chamow SM , Bennett GL , and Schwall RH (1995). Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am. J. Physiol. 268 (2 Pt 1): G380-G386.

Ryan AM , Bates Eppler D , Hagler KE , Bruner RH , Thomford PJ , Hall RL , Shopp GM , and O'Neill CA (1999). Preclinical safety evaluation of rhuMAbVEGF, an anti-angiogenic humanized monoclonal antibody. Toxicol. Pathol. 27: 78-86.

Ryan AM , Hagler K. , Bodary S. , Gadek T. , Lopez P. , Kowalski J. , and Cuthbertson RA (1997). αvβ3 and αvβ5 protein localization in a rat corneal angiogenesis model and in age related macular degeneration specimens. Vet. Pathol. 34: 476 (abstract).

Ryan AM , Hagler K. , Cuthbertson RA , and Miller J. (1997). The role of VEGF and VEGFR expression in experimental choroidal neovascularization. Vet. Pathol. 34: 475 (abstract).

Ryan AM , Hagler K. , Moore M. , and Carver-Moore K. (1997). Spontaneous renal disease in CD-1 GDNF heterozygous mice. Vet. Pathol. 34: 482 (abstract).

Ryan AM , Kim I. , Rohan R. , Amano S. , Agular S. , Miller JW , and Adamis AP (1999). Constitutive expression of VEGF, VEGFR-1 and VEGFR-2 in normal eyes. Invest. Ophthalmol. Vis. Sci. (in press).

Spencer SD , Di Marco F , Hooley J. , Pitts-Meek S. , Bauer M. , Ryan AM , Sordat B. , Gibbs VC , and Aguet M. (1998). The orphan receptor CRF 2-4 is an essential subunit of the interleukin-10 receptor. J. Exp. Med. 187: 571-578.

Wright BD , Klassen T. , Keyt B. , Hillan KJ , Ryan AM , and Cairns B. (1998). Immunolocalization of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and KDR/Flk-1) show distinct patterns in normal kidney. FASEB J. 12: A103 (abstract).

Xie J. , Murone M. , Luoh S-M. , Ryan A. , Gu Q. , Zhang C. , Bonifas JM , Lam C-W. , Hynes M. , Goddard A. , Rosenthal A. , Epstein EH , and deSauvage FJ (1998). Activating smoothened mutations in sporadic basal cell carcinoma. Nature 391: 90-93.