The C3(1)/SV40 T Antigen Transgenic Mouse Model of Prostate and Mammary Cancer

1. Barrios R , Lebovitz RM , Wiseman AL , Weisoly DL , Matusik RJ , DeMayo F , and Liebcrman MW (1996). RasT24 driven by a pro-basin promoter induces prostatic hyperplasia in transgenic mice. Transgenics 2: 23–28.

2. Bosland MC (1992). Animal models for the study of prostate carcinogenesis. J. Cell. Biochem. 16H(suppl.): 89–98.

3. Bostwick DG (1995). High grade prostatic intraepithelial neoplasia. The most likely precursor of prostate cancer. Cancer 75: 1823–1836.

4. Bostwick DG and Brawer MK (1987). Prostatic intra-epithelial neoplasia and early invasion in prostate cancer. Cancer 59: 788–794.

5. Brinster RL , Chen HY , Messing A , Van Dyke T , Levine AJ , and Palmiter RD (1984). Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37: 367–379.

6. Emmert-Buck MR , Vocke CD , Pozzatti RO , Duray PH , Jennings SB , Florence CD , Zhuang Z , Bostwick DG , Liotta LA , and Linehan WM (1995). Allelic loss on chromosome 8p12–21 in microdis-sected prostatic intraepithelial neoplasia. Cancer Res. 55: 2959–2962.

7. Green JE , Greenberg NM , Barrett JC , Boone C , Getzenberg RH , Henkin J , Matusik R , Padley RJ , and Scher HI (1998). Workshop on Animal Models of Prostate Cancer. Prostate 33: (in press).

8. Green JE , Maroulakou IG , Shibata M-A , and Anver M (1996). Heterotopic endochondral ossification associated with mixed tumor formation in C3(1)/TAg transgenic mice. Pediatr. Res. 39: 59A.

9. Greenberg NM , DeMayo F , Finegold MJ , Medina D , Tilley WD , Aspinall JO , Cunha GR , Donjacour AA , Matusik RJ , and Rosen JM (1995). Prostate cancer in a transgenic mouse. Proc. Natl. Acad. Sci. USA 92: 3439–3443.

10. Hanahan D (1985). Heritable formation of pancreatic b-cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115–122.

11. Harris JR , Lippman ME , Veronesi U , and Willett W (1992). Breast cancer. N. Engl. J. Med. 327: 319–328, 390–398.

12. Hurst HC and Parker MG (1983). Rat prostatic steroid binding protein: DNA sequence and transcript maps of the two C3 genes. EMBO J. 2: 769–774.

13. Isaacs WB , Bova GS , Morton RA , Bussenmakers MJ , Brooks JD , and Ewing CM (1994). Molecular biology of prostate cancer. Semin. Oncol. 21: 514–521.

14. Ittmann MM and Wieczorek R (1996). Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas. Hum. Pathol. 27: 28–34.

15. Jacks T , Remington L , Williams BO , Schmitt EM , Halachmi S , Bronson RT , and Weinberg RA (1994). Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4: 1–7.

16. Jorcyk CL , Liu M-L , Shibata MA , Maroulakou IG , Komschlies KL , McPhaul MJ , Resau JH , and Green JE (1998). Development and characterization of a mouse prostate adenocarcinoma cell line: ductal formation determined by extracellular matrix. Prostate 33: (in press).

17. Kitsberg DI and Leder P (1996). Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene 13: 2507–2515.

18. Kubota Y , Fujinami K , Uemura H , Dobashi Y , Miyamoto H , Iwasaki Y , Kitamura H , and Shuin T (1995). Retinoblastoma gene mutations in primary human prostate cancer. Prostate 27: 314–320.

19. Ludlow JW (1993). Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. FASEB J. 7: 866–871.

20. Maroulakou IG , Anver M , Garrett L , and Green JE (1994). Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene. Proc. Natl. Acad. Sci. USA 91: 11236–11240.

21. Maroulakou IG , Shibata M-A , Jorcyk CL , Chen X-X , and Green JE (1997). Reduced p53 dosage associated with mammary tumor metastasis in C3(1)/TAG transgenic mice. Mol. Carcinog. 20: 168–174.

22. Parker MGR , White H , Hurst M , Needham M , and Tilly R (1983). Prostatic steroid-binding protein. Isolation and characterization of C3 genes. J. Biol. Chem. 258: 12–15.

23. Parker SL , Tong TA , Bolden S , and Wingo PA (1996). Cancer statistics. CA Cancer J. Clin. 46: 5–27. [Comment, CA Cancer J. Clin. 46: 3–4, 1996].

24. Perez-Stable C , Altman NH , Brown J , Harbison M , Cray C , and Roos BA (1996). Prostate, adrenocortical, and brown adipose tumors in fetal globin/T antigen transgenic mice. Lab. Invest. 74: 363–373.

25. Perry ST , Viskochil DH , Ho K-C , Fong K , Stafford DW , Wilson EM , and French FS (1985). Androgen receptor binding to the C3(1) subunit gene of rat prostatein. In: Regulation of Androgen Action, N Bruchovsky , A Chapdelaine , and F Neumann (eds). Congress-druck R. Bruckner, Berlin, pp. 167–173.

26. Rushmere NK , Parker MG , and Davies P (1987). Androgen receptor-binding regions of an androgen-responsive gene. Mol. Cell. Endocrinol. 51: 259–265.

27. Shibata M-A , Jorcyk CJ , Devor DE , Yoshidome K , Rulong S , Resau J , Roche N , Roberts AB , Ward JM , and Green JE (1998). Altered expression of transforming growth factor βs during urethral and bulbourethral gland tumor progression in transgenic mice carrying the androgen-responsive C3(1) 5′ flanking region fused to SV40 large T antigen. Carcinogenesis 19: (in press).

28. Shibata M-A , Maroulakou IG , Jorcyk CL , Gold LG , Ward JM , and Green JE (1996). p53-Independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: Suppression of apoptosis during the transition from preneoplasia to carcinoma. Cancer Res. 56: 2998–3003.

29. Shibata M-A , Ward JM , Devor DE , Liu M-L , and Green JE (1996). Progression of prostatic intraepithelial neoplasia to invasive carcinoma in C3(1)/SV40 large T antigen transgenic mice: Histopathological and molecular biological alterations. Cancer Res. 56: 4894–4903.

30. Shirai T , Tamano S , Kato T , Iwasaki S , Takahashi S , and Ito N (1991). Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Cancer Res. 51: 1264–1269.

31. Tan J , Marschke KB , Ho S-C , Perry ST , Wilson EM , and French FS (1992). Response elements of the androgen-regulated C3 gene. J. Biol. Chem. 267: 4456–4466.

32. Tehranian A , Morris DW , Min BH , Bird DJ , Cardiff RD , and Barry PA (1996). Neoplastic transformation of prostatic and urogenital epithelium by the polyoma virus middle T gene. Am. J. Pathol. 149: 1177–1191.

33. Yan Y , Sheppard PC , Kasper S , Lin L , Hoare S , Kapoor A , Dodd JG , Duckworth ML , and Matusik RJ (1997). Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice. Prostate 32: 129–139.

34. Zhang X , Chen MW , Ng A , Ng PY , Lee C , Rubin M , Olsson CA , and Buttyan R (1997). Abnormal prostate development in C3(1)-bcl-2 transgenic mice. Prostate 32: 16–26.