Berezney R. and Coffey DS (1974) Identification of a nuclear protein matrix. Biochem. Biophys. Res. Commun . 60: 1410-1417.
2.
Brinkley BR , Ouspenski I., and Zinkowski RP (1992). Structure and molecular organization of the centromere-kinetochore complex . Trends Cell Biol. 2: 15-21.
3.
Compton DA and Cleveland DW (1993). NuMA is required for proper completion of mitosis . J. Cell Biol. 120: 947-957.
4.
He D., Nickerson JA, and Penman S. (1990). Core filaments of the nuclear matrix. J. Cell Biol. 110: 569-580.
5.
Lydersen B. and Pettijohn D. (1980). Human-specific nuclear proteins that associate with the polar regions of the mitotic apparatus: Distribution in a human/ hamster hybrid. Cell22: 489-499.
6.
Ozawa K., Dean FB, Chen M., Lee S.-H., Shiratori A., Murakami Y., Sakakura T., Hurwitz J., and Eki T. (1993). Mapping the 70 kDa, 34 kDa, and 11 kDa subunit of genes of the human multimeric single-stranded DNA binding proteins (hSSB/RPA) to chromosome bands 17 p13, 1p3S-p36.1 and 7jp21-p22. Cell Struct. Funct. 18: 221-230.
7.
Zeng C., He D., Berget SM, and Brinkley BR (1994). Nuclear-mitotic apparatus protein: A structural protein interface between the nucleoskeleton and RNA splicing. Proc. Natl. Acad. Sci. USA91: 1505-1509.
8.
Blasco MA, Funk W., Villeponteau B., and Greider CW (1995). Science269: 1267-1270.
9.
Collins K., Koybayashi R., and Greider CW (1995). Cell81: 677-686.
10.
Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, and Bacchetti S. (1992). EMBO J. 11: 1921-1929.
11.
Greider CW and Blackburn EH (1989). Nature (London)337: 331-337.
Prowse KR and Greider CW (1995). Proc. Natl. Acad. Sci. USA92: 4818-4822.
14.
Bregman DB, Du L., van der Zee S., and Warren SL (1995). Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains. J. Cell Biol. 129: 287-298.
15.
Carmo-Fonseca M., Tollervey D., Pepperkok R., Barabino SML, Merdes A., Brunner C., Zamore PD, Green MR, Hurt E., and Lamond AI (1991). Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery . EMBO J. 10: 195-206.
16.
Carter KC, Taneja KL, and Lawrence JB (1991). Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus. J. Cell Biol. 115: 1191-1202.
17.
Fu X-D. and Maniatis T. (1990). Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (London)343: 437-441.
18.
Spector DL , Fu X-D., and Maniatis T. (1991). Associations between distinct pre-mRNA splicing components and the cell nucleus . EMBO J. 10: 3467-3481.
19.
Xing Y. , Johnson CV, Dobner P., and Lawrence JB (1993). Higher level organization of individual gene transcription and RNA splicing: Integration of nuclear structure and function. Science259: 1326-1330.
20.
Hoeijmakers JHJ (1994). Human nucleotide excision repair syndromes: Molecular clues to unexpected intricacies. Eur. J. Cancer30A: 1912-19.
21.
Vermeulen W. , van Vuuren AJ, Appeldoorn E., Weeda G., Jaspers NGJ , Priestly A., Arlett CF, Lehmann AR, Stefanini M., Mezzina M., Sarasin A., Bootsma D., Egly J-M., and Hoeijmakers JHJ (1995 ). Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH). Evidence for the existence of transcription syndromes . Cold Spring Harbor Symp. Quant. Biol.59 (in press).
22.
Wang XW, Forrester K., Yeh H., Feitelson MA, Gu JR, and Harris CC (1994). Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA91: 2230-2234.
23.
Wang XW, Yeh H., Schaffer L., Roy R., Moncollin V., Egly JM, Wang Z., Friedberg EC, Evans MK, Taffe BG, Bohr VA, Hoeijmakers JH, Forrester K., and Harris CC (1995). p53 Modulation of TFIIH-associated nucleotide excision repair activity. Nature Genet. 10: 188-195.
24.
Arbeit J., Munger K., Howley P., and Hanahan D. (1994). Progressive squamous epithelial neoplasia in K14-HPV16 transgenic mice. J. Virol. 68: 4358-4368.
25.
Bossy-Wetzel E., Bravo R., and Hanahan D. (1992). Transcription factors JunB and c-Jun are selectively up-regulated and functionally implicated in fibrosarcoma development. Genes Dev. 6: 2340-2351.
26.
Christofori G., Naik P., and Hanahan D. (1994). Insulin-like growth factor II is focally up-regulated and functionally involved as a co-factor in oncogene induced tumorigenesis. Nature (London)369: 414-418.
27.
Christofori G., Naik P., and Hanahan D. (1995). Both imprinted and developmentally expressed alleles of IGF-II are deregulated during β cell tumorigenesis . Nature Genetics10: 196-201.
28.
Dietrich WF, Radany EH, Smith JS, Bishop JM, Hanahan D., and Lander EH (1994). Genome-wide search for LOH in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Proc. Natl. Acad. Sci. USA91: 9451-9455.
29.
Folkman J., Watson K., Ingber D., and Hanahan D. (1989). Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (London)339: 58-61.
30.
Hanahan D. (1985). Heritable formation of pancreatic β-cell tumors in transgenic mice harboring recombinant insulin/simian virus 40 oncogenes . Nature (London)315: 115-122.
31.
Kandel J., Bossy-Wetzel E., Radvanyi FR, Klagsbrun M., Folkman JF, and Hanahan D. (1991). Neovascularizaion is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell66: 1095-1104.
32.
Lacey M., Alpert S., and Hanahan D. (1986). The BPV genome elicits skin tumors in transgenic mice. Nature (London)322: 609-612.
33.
Lindgren V. , Sippola-Thiele M., Skowronski J., Wetzel E., Howley PM, and Hanahan D. (1989). Specific chromosomal abnormalities characterize fibrosarcomas of bovine papilloma virus-type 1 transgenic mice . Proc. Nat. Acad. Sci. USA86: 5025-5029.
34.
Vivanco MdM , Johnson R., Galante P., Hanahan D., and Yamamoto KR (1995). A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development . EMBO J. 14: 2217-2228.
35.
Hovens CM, Stacker SA, Andres AC, Harpur AG, Ziemiecki A., and Wilks AF (1992). RYK, a receptor tyrosoine kinase-related molecule with unusual kinase domain motifs. Proc. Natl. Acad. Sci. USA89: 11818-11822.
36.
Iwama A., Okano K., Sudo T., Matsuda Y., and Suda T. (1994). Molecular cloning of a novel tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Blood83: 3160-3169.
37.
Khazaie K., Schirrmacher V., and Lichtner RB (1993). EGF receptor in neoplasia and metastasis. Cancer Metastasis Rev. 12: 255-274.
38.
Rho O., Beltran LM, Gimenez-Conti IB, and DiGiovanni J. (1994). Altered expression of the epidermal growth factor receptor and transforming growth factor α during multistage skin carcinogenesis in SENCAR mice. Mol. Carcinogen. 11: 19-28.
39.
Archibald AL , McClenaghan M., Homsey V., Simons JP, and Clark AJ (1990). High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice. Proc. Natl. Acad. Sci. USA87: 5178-5182.
40.
Hunter T. and Pines J. (1994). Cyclins and cancer II: Cyclin D and cdk inhibitors come of age. Cell79:573-582.
41.
Keyomarsi K. and Pardee AB (1993). Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc. Natl. Acad. Sci. USA90: 1112-1116.
42.
Anderson NG , Maller JL, Tonks NK, and Sturgill K. (1990). Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature (London)343: 651-652.
Davis MA, Smith MW, Chang SH, and Trump BF (1994). Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line. Toxicol. Pathol. 22: 595-605.
45.
Hall A. (1993). Ras related proteins. Curr. Opin. Cell Biol. 5: 265-269.
46.
Moodie SA, Willumsen BM, Weber MJ, and Wolfman A. (1993). Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase. Science260: 1658-1661.
47.
DiGiovanni J. , Naito M., Walker SC, Beltran L., Chenicek KJ, and Show L. (1992). Further genetic analyses of skin tumor promotion susceptibility using inbred and recombinant inbred mice. Carcinogenesis13: 525-531.
48.
Naito M., Naito Y., Chenicek KJ, and DiGiovanni J. (1988). Susceptibility to phorbol ester skin tumor promotion in (C57BL/6 x DBA/2)F, mice is inherited as an incomplete dominant trait: Evidence for multi-locus involvement Carcinogenesis9: 639-645.
49.
Glick AB, Kulkarni AB, Tennenbaum T., Hennings H., Flanders KC, O'Reilly M., Sporn MB, Karlsson S., and Yuspa SH (1993). Loss of expression of transforming growth factor β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl. Acad. Sci. USA90: 6076-6080.
50.
Glick AB, Lee MM, Darwiche N., Kulkarni AB, Karlsson S., and Yuspa SH (1994). Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma. Genes Dev. 8: 2429-2440.
51.
Aguilar F., Harris CC, Sun T., Hollstein M., and Cerutti P. (1994) Geographic variation of p53 mutational profile in nonmalignant human liver. Science264: 1317-1319.
52.
Hussain SP, Aguilar F., Amstad P., and Cerutti P. (1994). Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene9: 2277-2281.
53.
Hussain SP, Aguilar F., and Cerutti P. (1994). Mutagenesis of codon 248 of the human p53 tumor suppressor gene by N-ethyl-N-nitrosourea. Oncogene9: 13-18.
54.
Mendelsohn M and Albertini R (eds) (1989). Mutations and the Environment, Pt. C. Wiley-Liss, New York.
55.
Zijlstra J. , Felley-Bosco E., Amstad P., and Cerutti P. (1990). A mammalian mutation system avoiding phenotypic selection: The RFLP/PCR approach . In: Mutagens and Carcinogens in the Diet. Wiley-Liss, New York , pp. 187-200.
56.
Counter CM, Avilion AA, LeFeuvre CEStewart NG, Greider CW, Harley CB, and Bacchetti S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase. EMBO J. 11: 1921-1929.
57.
Hollstein M. , Sidransky D., Vogelstein B. and Harris CC (1991). p53 mutations in human cancers. Science253: 49-52.
58.
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, and Shay JW (1994). Specific association of human telomerase activity with immortal cells and cancer. Science266: 2011-2015.
59.
Shay JW, Brasiskyte D., Ouellette M., Piatsyzek MA, Werbin H., Ying Y., and Wright WE (1994). Analysis of telomerase and telomeres. Methods Mol. Genet. 5: 263-280.
60.
Shay JW, Pereira-Smith OM, and Wright WE (1991). A role for both Rb and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196: 33-39.
61.
Shay JW, Tomlinson G., Piatsyzek MA, and Gollahon LS (1995). Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Mol. Cell Biol. 15: 425-432.
62.
Shay JW and Wright WE (1989). Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp. Cell Res. 184: 109-118.
63.
Shay JW, Wright WE, Brasiskyte D., and Van Der Haegan BA (1993). E6 of human papillomavirus type 16 can overcome the M 1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene8: 1407-1413.
64.
Shay JW, Wright WE, and Werbin H. (1993). Toward a molecular understanding of human breast cancer: A hypothesis. Br. Can. Res. Treat. 25: 83-94.
65.
Arbeit JM, Munger K., Howley PM, and Hanahan D. (1994). Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J. Virol. 68(7): 4358-4368.
66.
Burgess WH and Maciag T. (1989). The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev. Biochem. 58: 575-606.
67.
Hanahan D. (1985). Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes . Nature (London)315(6015): 115-122.
68.
Johnson DE and Williams LT (1993). Structural and functional diversity in the FGF receptor multigene family. Adv. Can. Res. 60: 1-41.
69.
Ron D., Reich R., Chedid M., Lengel C., Cohen OE, Chan AM, Neufeld G., Miki T., and Tronick SR (1993). Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. J. Biol. Chem. 268(8): 5388-5394.
70.
Greenblatt MS , Bennett WP, Hollstein M., and Harris CC (1994). Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis . Cancer Res. 54: 4855-4878.
71.
Guinee D., Trivia W., Trivers G., DeBenedetti VMG, Cawley HL, Bennnett W., Welsh J., Tazelaar H., Pairolero P., Trastek V., Caporaso N., Liotta L., and Harris C. (1995). Gender comparisons in human lung cancer: Analysis of p53 mutations, anti-p53 serum antibodies and C-erg-2 expression. Carcinogenesis16: 993-1002.
72.
Harris CC and Hollstein M. (1993). Clinical implications of the p53 tumor-suppressor gene. New Engl. J. Med. 329: 1318-1327.
73.
Hollstein M. , Marion M-J., Lehman T., Welsh J., Harris CC, Martel-Planche G., Kusters I., and Montesano R. (1994). p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis15: 1-3.
74.
Hengst L., Dulic V., Slingerland JM, Lees E., and Reed SI (1994). A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc. Natl. Acad. Sci. USA91: 5291-5295.
75.
Hengst L. and Reed SI (1995). Translation regulation of p27/p28Kip1/Ick1 levels during and upon exit from the cell cycle. Science (in press).
76.
Resnitzky D. , Gossen M., Bujard H., and Reed SI (1994). Acceleration of the G1/S phase transition by expression of cyclin D 1 and E with an inducible system . Mol. Cell. Biol. 14: 1669-1679.
77.
Resnitzky D. , Hengst L., and Reed SI (1995). Cyclin A-associated kinase activity is rate-limiting for entrance into S phase, and is negatively regulated in G1 by p27Kip1. Mol. Cell. Biol . 15: 4347-52.
78.
Resnitzky D. , Hengst L., and Reed SI (1995). Differential role for cyclins D 1 and E in regulation of the G1/S transition . Mol. Cell. Biol. 15: 3463-9.
79.
Hochstrasser M. (1995). Curr. Opin. Cell Biol. 7: 215-223.
80.
Nourse J., Firpo E., Flanagan M., Coats S., Polyak C., Lee M., Massague J., Crabtree G., and Roberts J. (1994). Nature (London)372: 570-573.
81.
Pagano M. , Tam SW, Theodoras AM, Beer-Romero P., Del Sal G., Chau V., Yew R., Draetta G., and Rolfe M. (1995). Science (in press).
82.
Rolfe M., Beer-Romero P., Glass S., Eckstein J., Berdo I., Theodoras A., Pagano M., and Draetta G. (1995). Proc. Natl. Acad. Sci. USA92: 3264-3268.
83.
Scheffner M. , Nuber U., and Huibregtse J. (1995). Nature (London)373: 81-83.
84.
Scheffner M. , Werness B., Huibregtse J., Levine A., and Howley P. (1990). Cell63: 1129-1136.
85.
Sherwood S., Kung A., Roitelman J., Simoni R., and Schimke R. (1993). Proc. Natl. Acad. Sci. USA90: 3353-3357.
86.
Guan K.-L, Jenkins CW, Li Y., Nichols MA, Wu X., O'Keefe CL, Matera AG, and Xiong Y. (1994). Growth suppression by p 18, a p16INK4 MTS1- and p14INK4B MTS2related CDK6 inhibitor, correlates with wild-type pRb function . Genes Dev. 8: 2939-2952.
87.
Li Y., Nichols MA, Shay JW, and Xiong Y. (1994). Transcriptional repression of the D-type cyclin-dependent kinases inhibitor p 16 by the retinoblastoma susceptibility gene product, pRb. Cancer Res. 54: 6078-6082.
88.
Xiong Y. , Zhang H., and Beach D. (1992). D-type cyclins associated with multiple protein kinases and the DNA replication and repair factor PCNA . Cell71: 505-514.
89.
Xiong Y. , Zhang H., and Beach D. (1993). Subunit rearrangement of cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 7: 1572-1583.
90.
Ceretti DP, Kozlosky CJ, Mosley B., Nelson N., Ness KV, Greenstreet TA, March, CJ, Kronheim SR, Druck T., Cannizzaro LA, Huebner K., and Black RA (1992). Molecular cloning of the interleukin-1β converting enzyme. Science256: 97-100.
91.
Debbas M. and White EJ (1993). Wild-type p53 mediate apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7: 546-554.
92.
Gagliardini V., Fernandez PA, Lee RKK, Drexler HCA, Rotello R., Fishman M., and Yuan J. (1994). Prevention of vertebrate neuronal death by the crmA gene. Science263: 826-828.
93.
McCarthy SA, Symonds HS, and Dyke TV (1994). Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation ofp53. Proc. Natl. Acad. Sci. USA91: 3979-3983.
94.
Miura M., Zhu H., Rotello R., Hartweig E., and Yuan J. (1993). Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegance cell death gene ced-3. Cell75: 653-660.
95.
Miyashita T. and Reed J. (1995) Tumor suppressor p53 is a direct transcription activator of the human bax. Gene Cell80: 293-299.
96.
Thornberry NA et al (1992). A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes . Nature (London)356: 768-774.
97.
Wang L., Miura M., Bergoren L., Zhu H., and Yuan J. (1994). Ich-1, an Ice/Ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell78: 739-750.
98.
Yuan J. and Horvitz HR (1990). Genetic mosaic analysis of ced-3 and ced-4, two genes that control programmed cell death in the nematode C. elegans. Dev. Biol. 138: 33-41.
99.
Yuan J., Shaham S., Ledoux S., Ellis HM, and Horvitz R. (1993). The C. elegance cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell75: 641-652.
100.
Hockenbery DM et al (1993). Bcl-2 functions in an antioxidant pathway to inhibit apoptosis. Cell75:241-251.
101.
Kane DJ et al (1993). Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science262: 1274-1277.
102.
Motoyama N. et al (1995). Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science267: 1506-1510.
103.
Williams GT (1993). Molecular regulation of apoptosis: Genetic controls on cell death. Cell74: 777-779.
104.
Yin X. -M, Oltvai ZN, and Korsmeyer SJ (1994). BH1 and BH2 domains of bc1-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature (London)369: 321-323.
105.
Davis MA, Smith MW, Chang SH, and Trump BF (1994). Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line. Toxicol. Pathol. 22: 595-605.
106.
Trump BF and Berezesky IK (1992). The role of cytosolic Ca2+ in cell injury, necrosis and apoptosis. Curr. Opin. Cell Biol. 4: 227-232.
107.
Trump BF and Berezesky IK (1995). Calcium-mediated cell injury and cell death. FASEB J. 9: 219-228.
108.
Wyllie AH, Kerr JFR, and Currie AR (1980). Cell death: The significance of apoptosis. Int. Rev. Cytol. 68: 251-306.
109.
Dong JT, Lamb P., Rinker-Schaeffer, Vukanovi J., Ichikawa T., Isaacs JT, and Barrett JC (1995). KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science268: 884-886.
110.
Ichikawa T., Ichikawa Y., and Isaacs JT (1991). Genetic factors and suppression of metastatic ability of prostatic cancer. Cancer Res. 54: 3788-3792.
111.
Ichikawa T., Nihei N., Suzuku H., Oshimura M.Emi M., Nakamura Y., Hayata I., Isaacs JT and Shimazaki J. (1994). Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8. Cancer Res. 54: 2292-2302.
112.
Rinker-Schaeffer CW, Partin AW, Isaacs WB, Coffey DS, and Isaacs JT (1994). Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells. Prostate25: 249-265.
113.
Tennenbaum T. , Belanger AJ, Glick AB, Tamura R., Quaranta V., and Yuspa SH (1995). A splice variant of α6 integrin is associated with malignant conversion in mouse skin tumorigenesis . Proc. Natl. Acad. Sci. USA92: 7041-7045.
114.
Tennenbaum T. , Weiner AK, Belanger AJ, Glick AB, Hennings H., and Yuspa SH (1993). The suprabasal expression of α6β4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis . Cancer Res. 53: 4803-4810.
115.
Weinberg WC, Azzoli CG, Chapman K., Levine AJ, and Yuspa SH (1995). p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. Oncogene10: 2271-2279.
116.
Weinberg WC, Azzoli CG, Kadiwar N., and Yuspa SH (1994). p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene. Cancer Res. 54: 5584-5592.
117.
Yuspa SH (1994). The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis-Thirty-third G.H. A. Clowes Memorial Award Lecture. Cancer Res. 54: 1178-1189.
118.
Campisi J.Dimri GP and Hara E. (1995). Control of replicative senescence. In: Handbook of the Biology of Aging , 4th ed., E Schneider and J Rowe (eds.) Academic Press, New York (in press).
119.
Dimri GP , Hara E., and Campisi J. (1994). Regulation of two E2F related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269: 16180-16186.
120.
Hara E. , Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., and Oda K. (1994). Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts . J. Biol. Chem. 269: 2139-2145.
121.
Noda A. , Ning Y., Venable SF, Pereira-Smith OM, and Smith JR (1994). Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211: 90-98.
122.
Rittling SR, Brooks KM, Cristofalo VJ, and Baserga R. (1986). Expression of cell cycle dependent genes in young and senescent WI38 fibroblasts. Proc. Natl. Acad. Sci. USA83:3316-3320.
123.
Seshadri T. and Campisi J. (1990). c-fos repression and an altered genetic program in senescent human fibroblasts. Science247 : 205-209.
124.
Stein GH, Drullinger LF, Robetorye RS, Pereira-Smith OM, and Smith JR (1991). Senescent cells fail to express cdc2, cycA and cycB in response to mitogen stimulation. Proc. Natl. Acad. Sci. USA88: 11012-11016.
125.
Counter CM, Hirte HW, Bacchetti S., and Harley CB (1994). Telomerase activity in human ovarian carcinoma . Proc. Natl. Acad. Sci. USA91: 2900-2904.
126.
Harley CB (1995). Telomeres and aging: Fact, fancy, and the future . J. Natl. Inst. Health Res. 7: 64-68.
127.
Hiyama E., Hiyama K., Yokoyama T., Matsuura Y., Piatyszek MA, and Shay JW (1995). Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Med. 1: 249-257.
128.
Hiyama E., Yokoyama T., Tasumoto N., Hiyama K., Imamura Y., Murakami Y., Kodama T., Piatyszek MA, Shay JW, and Matsuura Y. (1995). Telomerase activity in gastric cancer. Cancer Res. (in press).
129.
Hiyama K., Hiyama E., Ishioka S., Yamakido M., Inai K., Gazdar AF, Piatyszek MA, and Shay JW (1995).
130.
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, and Shay JW (1994). Specific association of human telomerase activity with immortal cells and cancer. Science266: 2011-2015.
131.
Shay JW, Pereira-Smith O., and Wright WE (1991). A role for both Rb and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196: 33-39.
132.
Shay JW, Tomlinson G., Piatyszek MA, and Gollahon LS (1995). Spontaneous in vitro immortalization of breast epithelial cells from a Li-Fraumeni patient. Mol. Cell. Biol . 15: 425-432.
133.
Wright W., Pereira-Smith O., and Shay JW (1989). Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts. Mol. Cell. Biol. 9: 3088-3092.
134.
Bennett LM, Haugen-Strano A., Fiedorek FT et al (1995). Isolation of the mouse homologue of BRGA1 and genetic mapping to mouse chromosome 11. Genomics (in press).
135.
Haugen-Strano A., Cochran C., and Wiseman RW (1995). Isolation and characterization of the mouse homologues of the MTS 1 and MTS2 genes. Proc. Am. Assoc. Can. Res. 36: 3436.
136.
Hegi, ME , Devereux TR, Dietrich W., et al (1994). Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation . Cancer Res. 54: 6257-6264.
137.
Herzog CR, Wiseman RW, and You M. (1994). Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res. 54: 4007-4010.
138.
Kamb A., Gruis NA, Weaver-Feldhaus J., et al (1994). A cell cycle regulator potentially involved in genesis of many types of cancer. Science264: 436-440.
139.
Miki Y., Swenson J., Schattuck-Eidens D., et al (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science266: 66-71.
140.
Wiseman RW, Cochran C., Dietrich W., et al (1994). Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: Frequent losses in regions homologous to human tumor-suppressor genes. Proc. Natl. Acad. Sci. USA91: 3759-3763.
141.
Fausto N. and Webber EM (1993). Mechanisms of growth regulation in liver regeneration and hepatic carcinogenesis. Prog. Liver Dis. 11: 115-137.
142.
Feitelson MA , Zhu M., Duan LX, and London WT (1993). Hepatitis B x antigen and p53 are associated with vitro and in tissues from patients with primary hepatocellular carcinoma. Oncogene8: 1109-1117.
143.
Jirtle RL, Meyer SA, and Brockenbrough JS (1991). Liver tumor promoter phenobarbital: A biphasic modulator of hepatocyte proliferation. Prog. Clin. Biol. Res. 369: 209-216.
144.
Kekule AS , Lauer U., Weiss L., Hofschneider PH, and Koshy R. (1992). Transactivation by hepatitis B virus X protein is mediated via a tumour promoter pathway. Arch. Virol. Suppl . 4: 63-64.
145.
Lee GH , Merlino G., and Fausto N. (1992). Development of liver tumors in transforming growth factor alpha transgenic mice. Cancer Res. 52: 5162-5170.
146.
Lindroos PM , Zarnegar R., and Michalopoulos GK (1991 ). Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration . Hepatology13: 743-750.
147.
Liu ML, Mars WM, Zarnegar R., and Michalopoulos GK (1994). Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-alpha in adult rat liver. Hepatology19(6): 1521-1527.
148.
Michalopoulos GK and Zarnegar R. (1992). Hepatocyte growth factor . Hepatology15: 149-155.
149.
Tsai WH and Michalopoulos GK (1991). Responsiveness of hepatocytes to epidermal growth factor, transforming growth factor-beta and norepinephrine during treatment with xenobiotic hepatic tumor promoters. Cancer Lett. 57(1): 83-90.
150.
Cavalieri EL , Higginbotham S., and Rogan E. (1994). Dibenzo[a,l]pyrene: The most potent carcinogenic aromatic hydrocarbon . Polycycl. Arom. Compounds6: 177-183.
151.
Li K-M., Ramakrishna NVS, Padmavathi NS, Rogan E., and Cavalieri EL (1994). Synthesis and structure determination of the adducts of dibenzo[a,l]pyrene diolepoxides and deoxyadenosine or deoxyguanosine. Polycycl. Arom. Compounds6: 207-213.
152.
Seidel A. , Luch A., Platt KL, Oesch F., and Glatt H. (1994). Activated fjord-region metabolites of dibenzo[a, l]pyrene: Synthesis and mutagenic activities of the diastereomeric syn- and anti-11,12-dihydrodiol-13,14-epoxides . Polycycl. Arom. Compounds6: 191-198.
153.
Aguillar F. , Harris CC, Sun T., Hollstein M., and Cerutti P. (1994). Geographic variation in mutational profile in nonmalignant human liver . Science264: 1317-1319.
154.
Aguillar F. , Hussain SP, and Cerutti P. (1993). Aflatoxin B, induces the transversion of G to T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA90: 8586-8590.
155.
Bressac B. , Kew M., Wands J., and Ozturk M. (1991). Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature (London)350: 429-431.
156.
Groopman JD, Hall A., Whittle H., Hudson G., Wogan GN, Montesano R., and Wild CP (1992). Molecular dosimetry of aflatoxin-N7-guanine in human urine obtained in The Gambia, West Africa. Cancer Epidemiol. Biomarkers Prev. 1: 221-227.
157.
Groopman JD, Hasler J., Trudel LG, Pikul A., Donahue PR, and Wogan GN (1992). Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and HPLC. Cancer Res. 52: 267-274.
158.
Groopman JD, Wogan GN, Roebuck BD, and Kensler TW (1994). Molecular biomarkers for aflatoxins and their application to human cancer prevention. Cancer Res.54: 1907s-1911s.
159.
Groopman JD, Zhu J., Chen J-S., and Wogan GN (1992). Molecular dosimetry of urinary aflatoxin DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China . Cancer Res. 52: 45-52.
160.
Harris CC (1993). p53: At the crossroads of molecular carcinogenesis and risk assessment. Science262: 1980-1981.
161.
Harris CC (1994). Solving the viral-chemical puzzle of human liver carcinogenesis. Cancer Epidemiol. Biomarkers Prev. 3: 1-2.
162.
Hsu IC, Metcalf RA, Sun T., Welsh J., Wang NJ, and Harris CC (1991). p53 mutational hotspot in human hepatocellular carcinoma from Qidong, China. Nature (London)350: 427-428.
163.
McGlynn KA, Rosvold EA, Lustbader ED, Hu Y., Clapper ML, Zhou T., Wild CP, Xia X-L., Baffoe-Bonnie A., Ofordi-Adjei D., Chen G-C., London WT, Shen F-M., and Buetow KH (1995). Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B,. Proc. Natl. Acad. Sci. USA92: 2384-2387.
164.
Qian G.-S., Ross RK, Yu MC, Yuan J.-M., Gao Y.-T., Henderson BE, Wogan GN, and Groopman JG (1994). A follow-up study of urinary markers of af latoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 3: 3-10.
165.
Ross RK, Yuan J-M., Yu MC, Wogan GN, Qian G-S., Tu J-T., Groopman JD, Gao Y-T., and Henderson BE (1992). Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet339: 943-946.
166.
Sheabar FZ, Morningstar ML, and Wogan GN (1994). Adduct detection by acylation with 35S-methionine: Analysis of DNA adducts of 4-aminobiphenyl. Proc. Natl. Acad. Sci. USA91: 1696-1700.
167.
Sheabar FZ, Morningstar ML, and Wogan GN (1994). Peracylation of nucleosides with methionine: Foundation for a method to detect carcinogen adducts. Chem. Res. Toxicol . 7: 650-658.
168.
Vineis P. and Caporaso N.( 1995). Tobacco and cancer: Epidemiology and the laboratory . Env. Health Perspect. 103: 156-160.
169.
Wogan GN (1992). Molecular epidemiology in cancer risk assessment and prevention: Recent progress and avenues for future research. Env. Health Perspect. 98: 167-178.
170.
Caporaso N., Landi MT, and Vineis P. (1991). Relevance of metabolic polymorphisms to human carcinogenesis : Evaluation of epidemiologic evidence. Pharmacogenetics1: 4-19.
171.
Frederickson SM, Messing EM, Reznikoff CA, and Swaminathan S. (1994). Relationship between in vivo acetylator phenotypes and cytosolic N-acetyltransferase and O-acetyltransferase activities in human urothelial cells. Cancer Epidemiol. Biomarkers Prev. 3: 25-32.
172.
Gelboin HV (1983). Carcinogen, drugs, and cytochrome P-450. N. Engl. J. Med. 309: 105-107.
173.
Hein DW, Doll MA, Rustan TD, Gary K., Feng Y., Ferguson RJ, and Grant DM (1993). Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT 1 and NAT2 acetyltransferases. Carcinogenesis. 14: 1633-1638.
174.
Kadlubar FF (1994). DNA adducts of carcinogenic aromatic amines. In: DNA Adducts, Identification and Biological Significances, K Hemminki, A Dipple, DEG Shuker, FF Kadlubar , D Segerbäck, and H Bartsch (eds). IARC Science Publication No. 125. IARC, Lyon, pp. 199-216.
175.
Vatsis KP and Weber WW (1993). Structural heterogenicity of Caucasian N-acetyltransferase at NAT1 gene locus. Arch. Biochem. Biophys. 301: 71-76.
176.
Bell DA , Taylor JA, Butler MA, et al (1993) Genotype/ phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis14: 1689-1692.
177.
Hayashi S., Watanabe J., Nakachi K., and Kawajiri K. (1991). Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J. Biochem. (Tokyo)110: 407-411.
178.
Seidegard J. , Vorachek WR, Pero RW, et al (1988). Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. USA85: 7293-7297.
179.
Shields PG and Harris CC (1991). Molecular epidemiology and the genetics of environmental cancerJ. Am. Med. Assoc. 266: 681-687.
180.
Chung KY, Mukhopadhyay T., Kim J., et al (1993). Discordant p53 mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res. 53: 1676-1683.
181.
Hong WK, Endicott J., Itri LM, et al (1986). 13-Cis retinoid acid in the treatment of oral leukoplakia. N. Engl. J. Med. 315: 1501-1505.
182.
Hong WK, Lippman SMHittelman WN et al (1995). Retinoid chemoprevention of aerodigestive cancer: Basic to clinic. Clin. Cancer Res. (in press).
183.
Hong WKLippman SMItri LM et al (1990). Prevention of second primary tumors with isotretinoin in squamous cell carcinoma of the head and neck. N. Engl. J. Med. 323: 795-801.
184.
Lippman SM , Batsakis JG, Toth BB, et a1 (1993). Comparison of low-dose isotretinoin with beta-carotene to prevent oral carcinogenesis . N. Engl. J. Med. 328(1): 15-20.
185.
Lippman SM , Benner SE, and Hong WK (1994). Cancer chemoprevention . J. Clin. Oncol. 12: 851-873.
186.
Lippman SM , Shin DM, Lee JJ, et al (1995). p53 and retinoid chemoprevention of oral carcinogenesis. Cancer Res. 55: 16-19.
187.
Lotan R., Xu X-C., Ro JY, et al (1995). Suppression of retinoic acid receptor β in oral premalignant lesions and its upregulation by isotretinoin. N. Engl. J. Med. 332: 1405-1410.
188.
Sporn MB (1991). Carcinogenesis and cancer: Different perspectives on the same disease. Cancer Res. 51: 6215-6218.
189.
Ashby J. and Tennant RW (1991). Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP . Mut. Res.. 257: 229-306.
190.
Donehower LA , Harvey M., Slagle BL, McArthur MJ, Montgomery CAJ , Butel JS and Bradley A. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature (London). 256: 215-221.
191.
Hansen LA and Tennant RW( 1994). Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin. Proc. Natl. Acad. Sci. USA. 91: 7822-7826.
192.
Leder A., Kuo A., Cardiff RD, Sinn E. and Leder P., (1990). v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. USA. 87: 9178-9182.
193.
Spalding JW , Momma J., Elwell MR and Tennant RW, (1993). Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene. Carcinogenesis. 14(7): 1335-1341.
194.
Tennant RW (1993). Stratification of rodent carcino- genicity bioassay results to reflect relative human hazard. Mut. Res. 286: 111-118.
195.
Gorelick, NJ (1995). Overview of mutation assays in transgenic mice for routine testing. Env. Mol. Mutagen . 25: 218-230.
196.
Gorelick NJ , O'Kelly JA, Biedermann KA, and deBoer J. (1995). UVA-induced mutational spectra in the lacl gene from transgenic mouse skin . Env. Mol. Mutagen.25(suppl. 25): 20 (abstract).
197.
Gorelick NJ, O'Kelly JA, Gu M., and Glickman BW (1995). Mutational spectra in the lacl gene in skin from 7,12-dimethylbenzanthracene (DMBA)-treated and untreated transgenic mice. Mol. Carcinog . 13 (in press).
198.
Gossen JA, DeLeeuw WJF , Tan CHT, Zwarthoff EC, Berends F., Lohman PHM, Knook DL, and Vijg J. (1989). Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA86: 7971-7975.
199.
Kohler SW, Provost GS, Fieck A., Kretz PL, Bullock WO, Sorge JA, Putman DL, and Short JM (1991). Spectra of spontaneous and mutagen-induced mutations in the lacl gene in transgenic mice. Proc. Natl. Acad. Sci. USA88: 7958-7962.
200.
Walker VE, Gorelick NJ, O'Kelly JA, Craft TR, deBoer J., Glickman BW, and Skopek TR (1994). Frequency and spectrum of ethylnitrosourea induced mutation at the hprt and lacl loci in splenic T-cells of exposed Big Blue® mice. Env. Mol. Mutagen.23 (suppl. 23): 71 (abstract).
201.
Chen X., Li R., Gong B., Davidson E., Dominguez JN, McKerrow JH, Kenyon GL and Cohen FE, (1995). Structure-based development of novel cysteine protease inhibitors by anti-parasitic drugs. In preparation.
202.
Cohen FE, Gregoret LM, Amiri P., Aldape K., Railey J., andMcKerrow JH (1991). Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling. Biochemistry . 30: 11221-11229.
203.
Eakin AE, McGrath ME, McKerrow JH, andFleuerick RJ (1993). Production of crystallizable cruzain, the major cysteine protease from Trypanosoma-cruzi. J. Biol. Chem. 268: 6115-6118.
204.
Li Z., Chen X., Davidson E., Zwang O., Mendis C., Ring CS, Roush WR, Fegley G., Li R., Rosenthal PJ, Lee GK, Kenyon GL, Kuntz ID, Cohen FE, (1994). Anti-malarial drug development using models of enzyme structure. Chem. Biol. 1: 31-37.
205.
Li R., Chen X., Gong B., Davidson E., Dominguez JN, Miller RE, Nuzum E., McKerrow JH, Kenyon GL, Cohen FE, (1995). In Vitro antimalarial activity of chalcones and their derivatives. J. Med. Chem. (submitted).
206.
McGrath ME, Eakin AE, Engel JC, andMcKerrow JH, (1995). The crystal structure of cruzain-A therapeutic target for Chagas disease. J. Mol. Biol. 247: 251-259.
207.
McKerrow JH , Sun E., Rosenthal PJ, and Bouvier J., (1993). The proteases and pathogenecity of parasitic protozoa. Annu. Rev. Microbiol. 47: 821-853.
208.
Ring CS andCohen FE (1993). Modeling protein structures-Construction and their applications. FASEB J. 7: 783-790.
209.
Ring CS, Sun E., McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, andCohen FE, (1993). Structure-based inhibitor design by using protein model for the development of antiparasitic agents. Proc. Natl. Acad. Sci. USA. 90: 3583-3587.
210.
Rosenthal PJ, McKerrow JH, Rasnick D., and Leech JH, (1989). Plasmodium-Falciparum-Inhibitors of lysosomal cysteine protineases inhibit a trophozoite proteinase and block parasite development. Mol. Bio- ichem. Parasitol. 35: 177-183.
211.
Hancock JF (1993). Anti-Ras drugs come of age. Current Biology3: 770-772.
212.
James GL et al. (1993). Benzodiazepine peptiomimetics: Potent inhibitors of ras Farnesylation in animal cells. Science260: 1937-1942.
213.
Bishop JM (1991). Molecular themes in oncogenesis. Cell64: 235-248.
214.
Casson AG, Mukhopadhyay T., Cleary KR, Ro JY, Levin B., and Roth JA (1991). p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res. 51: 4495-4499.
215.
Fujiwara T. , Cai DW, Georges RN, Mukhopadhyay T., Grimm EA, and Roth JA (1994). Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J. Natl. Cancer Inst. 86: 1458-1462.
216.
Fujiwara T., Grimm EA, Mukhopadhyay T., Zhang WW, Owen-Schaub L., and Roth JA ( 1994). Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res. 54: 2287-2291.
217.
Liu TJ , Zhang WW, Taylor DL, Roth JA, Goepfert H., and Clayman GL (1994). Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus . Cancer Res. 54: 3662-3667.
218.
Schneider PM, Casson AG, Levin B., Garewal HS, Hoelscher AH, Becker K., Dittler JH, Cleary KR, Troster M., Siewert JR, and Roth JA (1995). p53 mutations in Barrett's esophagus and Barrett's cancer: A prospective study of 98 cases. J. Thorac. Cardiovasc. Surg. (in press).
219.
Weinberg RA (1992). Tumor suppressor genes . Science254: 1138-1145.