Interstitial Cell Adenoma of the Rat Testis: Why is it Such a Problem in Toxicology Studies Using Sprague-Dawley Rats?

Bär A. (1992). Significance of Leydig cell neoplasia in rats fed lactitol or lactose. J. Am. Coll. Toxicol. 11(2): 189-207.

Bennington JL (ed) (1984 ). Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology . W. B. Saunders, New York, p. 184.

Boorman GA , Chapin RE , and Mitsumori K. (1990). Testis and epididymis. In: Pathology of the Fischer Rat, GA Boorman , SL Eustis , MR Elwell , CA Montgomery , and WF MacKenzie (eds). Academic Press , New York, pp. 405-418.

Boorman GA , Hamlin M. , and Eustis SL (1987). Focal interstitial cell hyperplasia, rat. In: The Male Genital System: Monograph on Pathology of Laboratory Animals , TC Jones , U Mohr , and RD Hunt (eds). Springer-Verlag, Berlin, pp. 200-204.

Cook JC , Murray SM , Frame SR , and Hurtt ME (1992). Induction of Leydig cell adenomas by ammonium perfluorooctanoate: A possible endocrine-related mechanism. Toxicol. Appl. Pharmacol. 113: 209-217.

Griffith RW (1988). Carcinogenic potential of marketed drugs. J. Clin. Res. Drug Dev. 2: 141-143.

Lang PL (1992). Spontaneous Neoplastic Lesions and Selected Non-Neoplastic Lesions in the Crl:CDBR Rat. Charles River, Wilmington, Massachusetts.

McConnell RF , Westen HH , Ulland BM , Bosland MC , and Ward JM (in press). Proliferative lesions of the testes in rats with selected examples from mice. In: Guides for Toxicologic Pathology. AFIP, Washington, D.C.

McMartin DN , Sabota PS , Gunson DE , Hsu HH , and Spaet RH (1992). Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicol. Pathol. 20: 212-225.