Scientific information on environmental tobacco smoke (ETS) is critically reviewed. Key areas addressed are: differences in chemical composition between mainstream smoke, sidestream smoke, and ETS; techniques for measurement of ETS; epidemiology; in vitro and in vivo toxicology; and chamber and field studies of perceptual or physiological effects. Questions concerning estimation of ETS exposure, suitability of various biomarkers, calculation of lifetime dose, control of confounding variables, use of meta-analysis, and the relationship between ETS concentrations and human responses all emphasize the need for additional research in order to assess potential effects of ETS on health or comfort.
1. Ames BN and Gold LS (1991). Endogenous mutagens and the causes of aging and cancer. Mutat. Res250: 3–16.
2.
2. Anderson E, Andelman R, Strauch J, Fortuin N, and Knelson J (1973). Effect of low-level carbon monoxide exposure on onset and duration of angina pectoris. Ann. Intern. Med79: 46–50.
3.
3. Angell M (1990). The interpretation of epidemiologic studies. N. Engl. J. Med323(12): 823–825.
4.
4. Aviado DM (1990). Non-epidemiologic studies on pulmonary carcinogens in enivronmental tobacco smoke: A critique of the environmental protection agency's designation for environmental tobacco smoke as a group A carcinogen. (Document submitted to EPA, September 25, 1990.)
5.
5. Ayesh R, Idle JR, Ritchie JC, Crothers MJ, and Hetzel MR (1984). Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature312: 169–170.
6.
6. Baker RR and Proctor CJ (1990). The origins and properties of environmental tobacco smoke. Environ. Int16(3): 231–246.
7.
7. Bascom R, Kulle T, Kagey-Sobotka A, and Proud D (1991). Upper respiratory tract environmental tobacco smoke sensitivity. Am. Rev. Respir. Dis143: 1304–1311.
8.
8. Beaumont JJ, Leveton J, Knox K, Bloom T, McQuiston T, Goldsmith R, Steenland KN, Brown DP, and Halperin WE (1987). Lung cancer and other causes of death among workers exposed to sulfuric acid mist in steel-pickling operations. Scand. J. Work Environ. Health13(2): 181.
9.
9. Blot WJ and Fraumeni JF Jr (1986). Passive smoking and lung cancer. J. Natl. Cancer Inst77: 993–1000.
10.
10. Boissel JP, Blanchard J, Panak E, Peyrieux JC, and Sacks H (1989). Considerations for the meta-analysis of randomized clinical trials. Controlled Clin. Trials10:254–281.
11.
11. Bombick DW, Ayres PH, Nelson PR, Coggins CRE, France D, Fulp C, Lee C, and Doolittle DJ (1991). Assessment of the biological activity of mainstream or environmental tobacco smoke (ETS) using a cellular smoke exposure technique. (Abstract presented at the 1991 National Environmental Mutation Society Meeting, Orlando, Florida.)
12.
12. Bond GG, Thompson FE, and Cook RR (1987). Dietary vitamin A and lung cancer: Results of a case-control study among chemical workers. Nutr. Cancer9(243): 109–121.
13.
13. Breslow L, Hoaglin M, Rasmussen G, and Abrtams HK (1954). Occupations and cigarette smoking as factors in lung cancer. Am. J. Public Health44: 171–81.
14.
14. Buiatti E, Kriebel D, Geddes M, Santucci M, and Pucci N (1985). A case-control study of lung cancer in Florence, Italy. I. Occupational risk factors. J. Epidemiol. Community Health39: 244–250.
15.
15. Byers T, Vena J, Mettlin C, Swanson M, and Graham S (1984). Dietary vitamin A and lung cancer risk: An analysis by histologic subtypes. Am. J. Epidemiol120(5): 769–776.
16.
16. Byers TE, Graham S, Haughey BP, Marshall JR, and Swanson MK (1987). Diet and lung cancer risk: Findings from the western New York diet study. Am. J. Epidemiol125(3): 351–363.
17.
17. Cain WS, Leaderer B, Isseroff R, Berglund L, Huey R, Lipsitt E, and Perlman D (1983). Ventilation requirements in buildings. I. Control of occupancy and tobacco smoke odor. Atmos. Environ17:1183.
18.
18. Cain WS, Tosun T, See LC, and Leaderer B (1987). Environmental tobacco smoke: Sensory reactions of occupants. Atmos. Environ21: 347–353.
19.
19. Caporaso N, Pickle LW, Bale S, Ayesh R, Hetzel M, and Idle J (1989). The distribution of debrisoquine metabolic phenotypes and implications for the suggested association with lung cancer risk. Genet. Epidemiol6: 517–524.
20.
20. Carson J and Erikson CA (1988). Results from surveys of environmental tobacco smoke in offices in Ottawa, Ontario. Environ. Technol. Lett9: 501–508.
22. Chalmers TC, Hewett P, Reitman D, and Sacks HS (1989). Selection and evaluation of empirical research in technology assessment. Int. J. Technol. Assess. Health Care5: 521–536.
23.
23. Ghrisley BM, Hendricks TS, and Driskell JA (1986). Vitamin B-6 status of a group of cancer patients. Nutr. Res6: 1023–1029.
24.
24. Coggins CRE, Ayres PH, Mosberg AT, Ogden MW, Sagartz JW, and Hayes AW (1992). Fourteen-day inhalation study in rats, using aged and diluted side-stream smoke from a reference cigarette. I. Inhalation toxicology; histopathology. Fundam. Appl. Toxicol19: 133–140.
25.
25. Coggins CRE, Ayres PH, Mosberg AT, Ogden MW, Sagartz JW, and Hayes AW (1993). 90-day inhalation study in rats, using aged and diluted side-stream smoke from a reference cigarette. I. Inhalation toxicology; histopathology. Inhalation Toxicol (in press).
26.
26. Cohen BH, Graves CG, Levy DA, Permutt S, Diamond EL, Kreiss P, Menekes HA, and Tockman MS (1977). A common familial component in lung cancer and chronic obstructive pulmonary disease. Lancet2(8037): 523–526.
27.
27. Colley JRT (1974). Respiratory symptoms in children and parental smoking and phlegm production. Br. Med. J2: 201–204.
28.
28. Connett JE, Kuller LH, Kjelsberg MO, Polk BF, Collins G, Rider A, and Hulley SB (1989). Relationship between carotenoids and cancer. Cancer64(1): 126–134.
29.
29. Crouse WE, Ireland MS, Johnson JM, Striegel RM, Williard CS, and DePinto RM (1990). Results from a survey of environmental tobacco smoke (ETS) in restaurants. In: Transactions: Combustion Processes and the Quality of Indoor Environment, JP Harper (ed). Air and Waste Management Association, Pittsburgh, Pennsylvania, pp. 214–222.
30.
30. Curvall M (1989). Urinary excretion of nicotine and its major metabolites. 43rd Tobacco Chemists' Research Conference, October 1989, Richmond, Virginia.
31.
31. Dahms TE, Bolin JF, and Slavin RG (1981). Passive smoking effects on bronchial asthma. Chest80(5): 530–534.
32.
32. De Labry LO, Campion EW, Glynn RJ, and Vokonas PS (1990). White blood cell count as a predictor of mortality: Results over 18 years from the normative aging study. J. Clin. Epidemiol43(2): 153–157.
33.
33. Department of Health and Social Security (1988). Fourth Report of the Independent Scientific Committee on Smoking and HealthLondon, Her Majesty's Stationery Office.
34.
34. Eatough D, Hansen L, and Lewis E (1988). Assessing Exposure to Environmental Tobacco Smoke, Indoor and Ambient Air Quality, R Perry and P Kirk (eds). Selper Ltd., London, pp. 131–140.
35.
35. Eatough D, Hansen L, and Lewis E (1990). The chemical characterization of environmental tobacco smoke. Environ. Technol11: 1071–1085.
36.
36. Edington DW (1988). University of Michigan study confirms links between smoking and poor health habits. University of Michigan News and Information Services. 30 pp.
37.
37. Engholm G, Englund A, and Lowing H (1987). Cancer incidence and mortality among Swedish painters. Scand. J. Work Environ. Health13(2): 181.
38.
38. Ernst E, Hammerschmidt DE, Bagge U, Matrai A, and Dormandy JA (1987). Leukocytes and the risk of ischemic diseases. J.A.M.A257: 2318–2324.
39.
39. Feinstein AR (1985). Clinical Epidemiology: The Architecture of Clinical ResearchWB Saunders Co., Philadelphia, Pennsylvania, pp. 124–125, 423–434.
40.
40. Ferron GA, Hayder B, and Kreyling WG (1985). A method for approximation of the relative humidity in the upper human airways. Bull. Math. Biol47: 565–589.
41.
41. Fisher, RA (1958). Statistical Methods for Research Workers, 13th ed. Oliver and Boyd, London.
42.
42. Fleiss JL and Gross AJ (1991). Meta-analysis in epidemiology, with special reference to studies of the association between exposure to environmental tobacco smoke and lung cancer: A critique. J. Clin. Epidemiol44: 127–139.
43.
43. Forastiere F, Lagorio S, Michelozzi P, Cavariani F, Arca M, Borgia P, Perucci C, and Axelson O (1986). Silica, silicosis and lung cancer among ceramic workers: A case-referent study. Am. J. Ind. Med10: 363–370.
44.
44. Fraser GE, Beeson L, and Phillips RL (1989). Diet and lung cancer in Seventh-day Adventists. Am. J. Epidemiol130(4): 840–841.
45.
45. Garland C, Barrett-Connor E, Suaraz L, Criqui M, and Wingard D (1985). Effects of passive smoking on ischemic heart disease mortality of nonsmokers. Am. J. Epidemiol121: 645–650.
46.
46. Garshick E, Schenker MB, Munoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, and Speizer FE (1988). A retrospective cohort study of lung cancer and diesel exhaust exposure in railroad workers. Am. Rev. Respir. Dis137: 820–825.
47.
47. Gillis C, Hole D, Hawthorne V, and Boyle P (1984). The effect of environmental tobacco smoke in two urban communities in the west of Scotland. Eur. J. Respir. Dis (Suppl. 133) 65: 121–126.
48.
48. Glass GV (1976). Primary, secondary, and metaanalysis of research. Educational Researcher5: 3–8.
49.
49. Glass GV, McGaw B, and Smith ML (1981). Metaanalysis in social researchSage Publications, Beverly Hills, California.
50.
50. Goodman MT, Kolonel LN, Yoshizawa CN, and Hankin JH (1988). The effect of dietary cholesterol and fat on the risk of lung cancer in Hawaii. Am. J. Epidemiol128(6): 1241–1255.
51.
51. Gori GB and Mantel N (1991). Mainstream and environmental tobacco smoke. Regul. Toxicol. Pharmacol14: 88–105.
52.
52. Gostomzyk J (1987). Passive smoking—Report on an international symposium (23–25 October 1986). Public Health49: 212–215.
53.
53. Guerin MR, Jenkins RA, and Tomkins BA (1992). The Chemistry of Environmental Tobacco Smoke: Composition and MeasurementLewis Publishers, Michigan.
54.
54. Guirgis HA and Harris RE (1976). Familial aggregation of lung cancer and other pulmonary diseases. Int. Congr. Series397: 77.
55.
55. Haley NJ, Colosimo SG, Axelrad CM, Harris R, and Sepkovic DW (1989). Biochemical validation of self-reported exposure to environmental tobacco smoke. Environ. Res49(1): 127–135.
56.
56. Haley NJ, Sepkovic DW, Brunneman KD, and Hoffman D.Biomarkers for assessing environmental tobacco smoke uptake. (Presented at the Air Pollution Control Association Special Conference on Combustion Processes and the Quality of the Indoor Air Environment, Niagara Falls, New York, September 1988.)
57.
57. He Y (1989). Women's passive smoking and coronary heart disease. Chung Hua Yu Fang I Hsueh Tsa Chih23: 19–22.
58.
58. Hedges LV and Olkin I (1985). Statistical methods for meta-analysisAcademic Press, New York.
59.
59. Helsing K, Sandler D, Comstock G, and Chee E (1988). Heart disease mortality in nonsmokers living with smokers. Am. J. Epidemiol127: 915–922.
60.
60. Hiller FC, Mazumder MK, Wilson JD, McLeod PC, and Bone RC (1982). Human respiratory tract deposition using multimodel aerosols. J. Aerosol. Sci13: 337–343.
61.
61. Hinds W, First MW, Huber GL, and Shea JW (1983). A method for measuring the deposition of cigarette smoke during smoking. Am. Ind. Hyg. Assoc. J44: 113–118.
62.
62. Hinds MW, Kolonel LN, Hankin JH, and Lee J (1984). Dietary vitamin A, carotene, vitamin C and risk of lung cancer in Hawaii. Am. J. Epidemiol119(2): 227–236.
63.
63. Hirayama T (1981). Non-smoking wives of heavy smokers have a higher risk of lung cancer: A study from Japan. Br. Med. J282: 183–185.
64.
64. Hirayama T (1984). Lung cancer in Japan: Effects of nutrition and passive smoking. In: Lung Cancer: Causes and Prevention, M. Mizell and P. Correa (eds). Verlag Chemie International, New York, pp. 175–195.
65.
65. Hole D, Gillis C, Chopra C, and Hawthorne V (1989). Passive smoking and cardiorespiratory health in a general population in the west of Scotland. Br. Med. J299: 423–427.
66.
66. Hole DJ, Gillis CR, and Hawthorne VM (1989). Which smokers develop lung cancer?Br. J. Cancer60(3): 469.
67.
67. Hood RD, Wu JM, Witorsch RJ, and Witorsch P (1991). Environmental tobacco smoke exposure and respiratory health in children: An updated critical review and analysis of the epidemiological literature. Indoor Environ1: 19–35.
68.
68. Hull CJ, Doyle E, Peters JM, Garabrant DH, Bernstein L, and Preston-Martin S (1989). Case-control study of lung cancer in Los Angeles County, California, USA welders. Am. J. Ind. Med16(1): 103–112.
69.
69. Humble C, Croft J, Berger A, Casper M, Hames C, and Tyroler H (1990). Passive smoking and twenty year cardiovascular disease mortality among nonsmoking wives in Evans County, Georgia. Am. J. Public Health80: 599–601.
70.
70. Hurshman L, Brown B, and Guyton R (1978). The implications of sidestream cigarette smoke for cardiovascular health. J. Environ. Health41:145–149.
71.
71. Ingebrethsen BJ and Sears SB (1989). Particle evaporation of sidestream smoke in a stirred tank. J. Colloid Interface Sci131: 526–536.
72.
72. International Agency for Research on Cancer (IARC) (1987). Environmental Carcinogens—Methods of Analysis and Exposure Measurement, Vol. 9: Passive SmokingIARC Scientific Publications, Lyon, no. 81.
73.
73. Jenicek M (1989). Meta-analysis in medicine. Where we are and where we want to go. J. Clin. Epidemiol42: 35–44.
74.
74. Kannel WB, D'Agostino RB, and Belanger AJ (1987). Fibrinogen, cigarette smoking, and risk of cardiovascular disease: Insights from the Framingham Study. Am. Heart J113(4): 1006–1010.
75.
75. Kay DLC, Heavner DL, Nelson PR, Jennings RA, Eaker DW, Robinson JH, DeLuca PO, and Risner CH (1990). Effects of relative humidity on non-smoker response to environmental tobacco smoke. In: Indoor Air 90, Vol. 1: Human health, Comfort and Performance, D. Walkinshaw (ed). International Conference on Indoor Air Quality and Climate, Inc., Ottawa, Ontario, pp. 275–280.
76.
76. Koo LC (1988). Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked. Nutr. Cancer11: 155–172.
77.
77. Kuller L, Ockene J, Meilahn E, and Svendsen K (1989). Relationship of pulmonary function to lung cancer in the MRFIT trial. Prev. Med18(5): 761–762.
78.
78. Kune GA, Kune S, Watson LF, Pierce R, Field B, Vitetta L, Merenstein D, Hayes A, and Irving L (1989). Serum levels of β-carotene, vitamin A, and zinc in male lung cancer cases and controls. Nutr. Cancer12(2): 169–176.
79.
79. Lazarus NB, Kaplan GA, Cohen RD, and Leu D-J (1989). Smoking and body mass in the natural history of physical activity: Prospective evidence from the Alameda County study, 1965–1914. Am. J. Prev. Med5(3): 127–135.
80.
80. Lebowitz M and Burrows B (1976). Respiratory symptoms related to smoking habits of family adults. Chest69: 48–50.
81.
81. Lee CK, Brown BG, Reed B, Rahn C, Coggins CRE, Doolittle DJ, and Hayes AW (1991). Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. II. DNA adducts and alveolar macrophage cytogenetics. Fundam. Appl. Toxicol19: 141–146.
82.
82. Lee P (1987). Lung cancer and passive smoking: Association an artefact due to misclassification of smoking habits?Toxicol. Lett35: 157–162.
83.
83. Lee P, Chamberlain J, and Alderson M (1986). Relationship of passive smoking to risk of lung cancer and other smoking-associated diseases. Br. J. Cancer54: 97–105.
84.
84. Lerchen ML, Wiggins CL, and Samet JM (1987). Lung cancer and occupation in New Mexico. J. Natl. Cancer Inst79(4): 639–645.
85.
85. Letzel H, Blumner E, and Uberla K (1988). Metaanalyses on passive smoking and lung cancer effects of study selection and misclassification of exposure. Environ. Technol. Lett9: 491–500.
86.
86. Letzel H and Uberla K (1990). Meta-analyses on passive smoking and lung cancer. In: Indoor Air Quality, H. Kasuga (ed). Springer-Verlag, Berlin, pp. 316–322.
87.
87. Lioy PJ (1990). Exposure analysis and assessment for low risk cancer agents. Int. J. Epidemiol19(3s1): 53s–61s.
88.
88. Maher KV and DeFonso LR (1987). Respiratory cancer among chloromethyl ether workers. J. Natl. Cancer Inst78(5): 839–843.
89.
89. Mantel N (1987). Lung cancer and passive smoking. Br. Med. J.294: 440.
90.
90. Mantel N and Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst.22: 719–748.
91.
91. Marchand LL, Yoshizawa CN, Kolonel LN, Hankin JH, and Goodman MT (1989). Vegetable consumption and lung cancer risk: A population-based case-control study in Hawaii. J. Natl. Cancer Inst81: 1158–1164.
92.
92. Martin M, Hunt S, and Williams R (1986). Increased incidence of heart attacks in nonsmoking women married to smokers. (Presented at the annual meeting of the American Public Health Association, October 1986.)
93.
93. Matsukura S, Taminato T, Kitano N, Seino Y, Hamada H, Uchihashi M, Nakajima H, and Hirata Y (1984). Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. N. Engl. J. Med311(13): 828–832.
94.
94. McBride JT (1989). Clinical effects of insults to the growing lung. Lung Growth & Development: Basic & Clinical Considerations (Postgraduate course presented at the American Thoracic Society Meeting, Cincinnati, Ohio).
95.
95. McDuffie HH, Klaassen DJ, Crockcroft DW, and Dosman JA (1988). Farming and exposure to chemicals in male lung cancer patients and their siblings. J. Occup. Med30(1): 55–59.
96.
96. McDuffie HH, Klaassen DJ, and Dosman JA (1987). Evidence for familial but nongenetic association of primary lung cancer. Amer. J. Hum. Genet41(Suppl. 3): A31.
97.
97. Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA, and Brookmeyer R (1986). Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. New Engl. J. Med315(20): 1250–1254.
98.
98. Mettlin C (1989). Milk drinking, other beverage habits, and lung cancer risk. Int. J. Cancer43: 608–612.
99.
99. Muramatsu T, Weber A, Muramatsu S, and Akerman F (1983). An experimental study of irritation and annoyance due to passive smoking. Int. Arch. Occup. Environ. Health51: 305–317.
100.
100. Myers RH, Kiely DK, Genest J, Farrer LA, Wilson PWF, and Schaffer EJ (1989). Familial similarity in lipoprotein cholesterols: The Framingham study. Am. J. Hum. Genet (Suppl. 4) 45: A246.
101.
101. National Research Council (1986). Environmental Tobacco Smoke: Measuring Exposures and Assessing Health EffectsNational Academy Press, Washington, D.C.
102.
102. Nelson PR, Heavner DL, and Oldaker GB III (1990). Problems with the use of nicotine as a predictive environmental tobacco smoke marker. Proceedings of the 1990 EPA/A&WMA International Symposium: Measurement of Toxic and Related Air Pollutants Air & Waste Management Assoc., Pittsburgh, Pennsylvania, pp. 550–555.
103.
103. Nelson PR and Ogden MW (1990). Measurement of ethenylpyridine in environmental tobacco smoke. Proceedings of the 38th ASMS Conference on Mass Spectrometry and Allied TopicsTucson, Arizona, June 1990. pp. 677–678.
104.
104. Nelson PR, deBethizy JD, Davis RA, and Oldaker GB III (1991). Where there's smoke? Biases in the use of nicotine and cotinine as environmental tobacco smoke biomarkers. Proceedings of the 1991 EPAIA&WMA International Symposium: Measurement of Toxic and Related Air Pollutants Air & Waste Management Assoc., Pittsburgh, Pennsylvania, pp. 449–454.
105.
105. Nystrom C and Green C (1986). Assessing the impact of environmental tobacco smoke on indoor air quality: Current status. (Presentation, ASHRAE Indoor Air Quality Conference, Atlanta, Georgia.)
106.
106. Ogden MW and Maiolo KC (1988). Collection and analysis of solanesol as a tracer of environmental tobacco smoke (ETS). In: Indoor and Ambient Air Quality, R Perry and P Kirk (eds). Selper Ltd., London, pp. 77–88.
107.
107. Oldaker GB, Perfetti PF, Conrad FW, Conner JM, and McBride RL (1990). Results from surveys of environmental tobacco smoke in offices and restaurants. In: Indoor Air Quality, H Kasuga (ed). Springer-Verlag, Berlin, pp. 99–104.
108.
108. Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE, and Rothschild H (1986). Familial lung cancer-correcting an error in calculation. J. Natl. Cancer Inst76: 217–222.
109.
109. O'Rourke K and Detsky AS (1989). Meta-analysis in medical research: Strong encouragement for higher quality in individual research efforts. J. Clin. Epidemiol42: 1021–1024.
110.
110. Pastorino U, Pisani P, Berrino F, Andreoli C, Barbieri A, Costa A, Mazzoleni C, Gramegna G, and Marubini E (1987). Vitamin A and female lung cancer: A case-control study on plasma and diet. Nutr. Cancer10(4): 171–179.
111.
111. Perusse L, Leblanc C, Tremblay A, Allard C, Theriault G, Landry F, Talbot J, and Bouchard C (1987). Familial aggregation in physical fitness, coronary heart disease risk factors, and pulmonary function measurements. Prev. Med16: 607–615.
112.
112. Pisani P, Berrino F, Macaluso M, Pastorino U, Crosignani P, and Baldasseroni A (1986). Carrots, green vegetables and lung cancer: A case-control study. Intl. J. Epidemiol15(4): 463–468.
113.
113. Proctor C (1988). The analysis of the contribution of ETS to indoor air. In: Indoor and Ambient Air Quality, R Perry and P Kirk (eds). Selper Ltd., London, pp. 57–66.
114.
114. Puntoni R, Goldsmith DF, and Vercelli M (1987). A cohort study of workers employed in a refractory brick plant. Scand. J. Work Environ. Health13(2): 162.
115.
115. Russell M, Cole P, and Brown E (1973). Absorption by nonsmokers of carbon monoxide from room air polluted by tobacco smoke. Lanceti: 576–579.
116.
116. Sacks HS, Berrier J, Reitman D, Ancona-Berk VA, and Chalmers TC (1987). Meta-analyses of randomized controlled trials. N. Engl. J. Med316: 450–455.
117.
117. Sakai R (1989). Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet. Jpn. J. Cancer Res80: 513–520.
118.
118. Samet JM, Humble CG, and Pathak DR (1986). Personal and family history of respiratory disease and lung cancer risk. Am. Rev. Respir. Dis134:466–470.
119.
119. Samet JM (1989). Radon and lung cancer: How great is the risk?J. Respir. Dis10(7): 73–83.
120.
120. Samet JM, Pathak DR, Morgan MV, Key CR, and Valdivia AA (1989). Exposure to radon decay products and lung cancer risk in a cohort of New Mexico uranium miners. Am. Rev. Respir. Dis139(4,2): A26.
121.
121. Scherer G, Conze C, Meyerinck LV, Sorsa M, and Adlkofer F (1990). Importance of exposure to gaseous and particulate phase components of tobacco smoke in active and passive smokers. Int. Arch. Occup. Environ. Health62(6): 459–466.
122.
122. Schilling R, Letai A, Hui S, Beck G, Schoenberg J, and Bouhuys A (1977). Lung function, respiratory disease, and smoking in families. Am. J. Epidemiol106: 274–283.
123.
123. Shephard RJ, Collins R, and Silverman F (1979). Passive exposure of asthmatic subjects to cigarette smoke. Environ. Res20: 392–402.
124.
124. Shibata A, Sasaki R, Ito Y, Hamajima N, Suzuki S, Ohtani M, and Aoki K (1989). Serum concentration of beta-carotene and intake frequency of green-yellow vegetables among healthy inhabitants of Japan. Int. J. Cancer44: 48–52.
125.
125. Sidney S, Caan BJ, and Friedman GD (1989). Dietary intake of carotene in nonsmokers with and without passive smoking at home. Am. J. Epidemiol129: 1305–1309.
126.
126. Sluis-Cremer GK and Bezuidenhout BN (1989). Relation between asbestos and bronchial cancer in amphibole asbestos miners. Br. J. Ind. Med46: 537–540.
127.
127. Sorahan T and Cathcart M (1989). Lung cancer mortality among workers in a factory manufacturing chlorinated toluenes: 1961–84. Br. J. Ind. Med46: 425–427.
128.
128. Spitzer WO (1991). Meta-analysis: Unanswered questions about aggregating data. J. Clin. Epidemiol44: 103–107.
129.
129. Stankus RP, Menon PK, Rando RJ, Glindmeyer H, Salvaggio JE, and Lehrer SB (1988). Cigarette smoke-sensitive asthma: Challenge studies. J. Clin. Immunol82: 331–338.
130.
130. Svendsen K, Kuller L, Martin M, and Ockenee J (1987). Effects of passive smoking in the multiple risk factor intervention trial. Am. J. Epidemiol126: 783–795.
131.
131. Tager I, Weiss S, Rosner B, and Speizer F (1979). Effect of parental cigarette smoking on the pulmonary function of children. Am. J. Epidemiol110: 2684.
132.
132. Taylor RG (1987). Smoking and the leukocyte count. Eur. J. Respir. Dis71: 65–68.
133.
133. Thomas TL and Stewart PA (1987). Mortality from lung cancer and respiratory disease among pottery workers exposed to silica and talc. Am. J. Epidemiol125(1): 35–43.
134.
134. Tokuhata GK and Lilienfeld AM (1963). Familial aggregation of lung cancer among hospital patients. Public Health Rep78(4): 277–283.
135.
135. Tola S, Kalliomaki PL, and Pukkala E (1987). Cancer incidence among shipyard and machine shop workers. Scand. J. Work. Environ. Health13(2): 180.
136.
136. Trichopoulos D, Kalandidi A, Sparros L, and MacMahon B (1981). Lung cancer and passive smoking. Int. J. Cancer27(1): 1–4.
137.
137. US Department of Health and Human Services (1983). The Health Consequences of Smoking. Cardiovascular Disease. A Report of the Surgeon General Publ. no. DHHS(PHS) 84–50204.
138.
138. US Department of Health and Human Services (1986). The Health Consequences of Involuntary Smoking. A Report of the Surgeon General Publ. no. DHHS(CDC) 87–8398, pp. 134–137.
139.
139. US Environmental Protection Agency, Office of Health and Environment Assessment, Office of Atmospheric and Indoor Air Programs (1990). Health Effects of Passive Smoking: Assessment of Lung Cancer in Adults and Respiratory Disorders in Children External Review Draft, EPA 600/6–90/006A, May, 1990.
140.
140. Vineis P, Thomas T, Hayes RB, Blot WJ, Mason TJ, Pickle LW, Correa P, Fontham ETH, and Schoenberg J (1988). Proportion of lung cancers in males, due to occupation, in different areas of the USA. Int. J. Cancer42: 851–856.
141.
141. von Meyerinck L, Scherer G, Adlkofer F, Wenzel-Hartung R, Brune H, and Thomas C (1989). Exposure of rats and hamsters to sidestream smoke from cigarettes in a subchronic inhalation study. Exp. Pathol37: 186–189.
142.
142. Wald NJ, Nanchahal K, Thompson SG, and Cuckle HS (1986). Does breathing other people's tobacco smoke cause lung cancer?Br. Med. J293: 1217–1222.
143.
143. Walker JC, Jennings RA, Morgan WT, Robinson JH, Griffith DW, and Reynolds JH IV (1989). Sensory responses to environmental tobacco smoke from cigarettes that heat but do not burn tobacco. In: Present and Future of Indoor Air Quality, CJ Bieva, Y Courtois, and M Govaerts (eds). Elsevier, New York, pp. 207–213.
144.
144. Weber A, Fischer T, and Grandjean E (1979a). Passive smoking: Irritating effects of the total smoke and the gas phase. Int. Arch. Occup. Environ. Health43: 183–193.
145.
145. Weber A, Fischer T, and Grandjean E (1979b). Passive smoking in experimental and field conditions. Environ. Res20: 205–216.
146.
146. Wells AJ (1988). An estimate of adult mortality in the United States from passive smoking. Environ. Int14: 249–265.
147.
147. Whichelow MJ, Golding JF, and Treasure FP (1988). Comparison of some dietary habits of smokers and non-smokers. Br. J. Addict83: 295–304.
148.
148. White J and Froeb H (1980). Small-airways dysfunction in nonsmokers chronically exposed to tobacco smoke. N. Engl. J. Med302(13): 720–723.
149.
149. Wiedemann HP, Mahler DA, Loke J, Virgulto JA, Snyder P, and Matthay RA (1986). Acute effects of passive smoking on lung function and airway reactivity in asthmatic subjects. Chest89(2): 180–184.
150.
150. Wynder EL (1987). Workshop on guidelines to the epidemiology of weak associations. Prev. Med16: 139–141.
151.
151. Wynder EL, Herbert JR, and Kabat GC (1987). Association of dietary fat and lung cancer. J. Natl. Cancer Inst19(4): 631–637.
152.
152. Yusuf S (1987). Obtaining medically meaningful answers from an overview of randomized clinical trials. Stat. Med6: 281–286.
153.
153. Yusuf S, Peto SR, Lewis J, Collins R, and Sleight P (1985). Beta blockade during and after myocardial infarction: An overview of the randomized trials. Prog. Cardiovasc. Dis27: 335–371.
154.
154. Zahm SH, Brownson RC, Chang JC, and Davis JR (1989). Study of lung cancer histologic types, occupation, and smoking in Missouri. Am. J. Ind. Med15: 565–578.
155.
155. Ziegler RG, Mason TJ, Stemhagen A, Hoover R, Schoenberg JB, Gridley G, Virgo PW, Altman R, and Fraumeni JF, Jr. (1984). Dietary carotene and vitamin A and risk of lung cancer among white men in New Jersey. J. Natl. Cancer Inst73(6): 1429–1435.
156.
1. Feinstein AR (1988). Scientific standards in epidemiologic studies of the menace of daily life. Science242: 1257–1263.
157.
2. Fleiss JL and Gross AJ (1991). Meta-analysis in epidemiology, with special reference to studies of the association between exposure to environmental tobacco smoke and lung cancer: A critique. J. Clin. Epidemiol44: 127–139.
158.
3. Smith CJ, Sears SB, Walker JC, and DeLuca PO (1992). Environmental tobacco smoke: Current assessment and future directions. Toxicol. Pathol20(2): 289–303.
159.
4. Spitzer WO, Dales R, Schecter MT, Tousignant P, and Hutcheon M (1987). Subjective fears and objective data: An epidemiologic study of environmental health concerns. Trans. Assoc. Am. Physicians100: 40–44.
160.
5. Surgeon General's Report (1964). The Health Consequences of Smoking.
