A histiocytic sarcoma in an aging female gerbil is described. The neoplasm primarily involved the spleen and liver, and these organs were considered the primary sites of neoplastic origin. No neoplastic infiltration was noted in the uterus or ovaries as is commonly seen in the female mouse. This is the first report of histiocytic sarcoma in gerbils.
1. Bellomi A and Gamoletti R (1981). Malignant histiocytic tumor presenting as a primary uterine neoplasm: A cytochemical and electron microscopy study. J. Pathol134: 233–241.
2.
2. Benitz KF and Kramer AW Jr (1965). Spontaneous tumors in the Mongolian gerbil. Lab. Anim. Care15: 281–294.
3.
3. Chouroulinkov I, Guillon J, and Guerin M (1969). Endometrial sarcomas in mice: A survey of 130 cases. J. Natl. Cancer Inst42: 593–603.
4.
4. Dawson PI, Brooks RE, and Fieldsteel AH (1974). Unusual occurrence of endometrial sarcomas in hybrid mice. J. Natl. Cancer Inst52: 207–214.
5.
5. Dunn TB (1954). Normal and pathologic anatomy of the reticular tissue in laboratory mice. J. Natl. Cancer Inst14: 1281–1433.
6.
6. Delia Porta G, Chieco-Bianchi L, and Pennelli N (1979). Tumors of the hematopoietic system. In: Pathology of Tumours in Laboratory Animals, Vol. II. Tumours of the Mouse, VS Turusov (ed). International Agency for Research on Cancer, Lyon, pp. 527–576.
7.
7. Frith CH (1990). Histiocytic sarcoma, mouse. In: Hematopoietic System: Monographs on Pathology of Laboratory Animals, TC Jones, JM Ward, and RD Hunt (eds). Springer-Verlag, Berlin, pp. 58–65.
8.
8. Frith CH (1988). Morphologic classification and incidence of hematopoietic neoplasms in the Sprague-Dawley rat. Toxicol. Pathol16: 451–457.
9.
9. Frith CH, Davis TM, Zolotor LA, and Townsend J (1980). Histiocytic lymphoma in the mouse. Leuk. Res4: 651–662.
10.
10. Frith CH, Pattengale PK, and Ward JM (1985). A Color Atlas of Hematopoietic Pathology of Mice Toxicology Pathology Associates, Little Rock, pp. 12, 13.
11.
11. Frith CH and Wiley LD (1981). Morphologic classification and correlation of incidence of hyperplastic and neoplastic hematopoietic lesions in mice with age. J. Geront36: 534–545.
12.
12. Gillman J, Gillman T, and Gilbert C (1949). Reticulosis and reticulum-cell tumors of the liver produced in rats by trypan blue with reference of hepatic necrosis and fibrosis. S. Afr. J. Med. Sci14: 21–83.
13.
13. Hsu S-M, Ho Y-S, and Hsu P-L (1991). Lymphomas of true histiocytic origin, expression of different phenotypes in so-called true histiocytic lymphoma and malignant histiocytosis. Am. J. Pathol138: 1389–1404.
14.
14. Lasser A (1983). The mononuclear phagocyte system: A review. Hum. Pathol14: 108–126.
15.
15. Meckley PE and Zwicker GM (1979). Naturally-occurring neoplasms in the Mongolian gerbil, Meriones unguiculatus. Lab. Animals13: 203–206.
16.
16. Port CD, Van Pelt LF, and Williams RM (1982). Histiocytic sarcoma of the scrotum in a rat. Lab. Anim. Sci32: 74–77.
18. Rowe SE, Simmons DH, Ringler DH, and Lay DM (1974). Spontaneous neoplasms in aging gerbillinae. A summary of forty-four neoplasms. Vet. Pathol11: 38–51.
19.
19. Squire RA, Brinkhous KM, Peiper SC, Firminger HI, Mann RB, and Strandberg JD (1981). Histiocytic sarcoma with a granuloma-like component occurring in a large colony of Sprague-Dawley rats. Am. J. Pathol105: 21–30.
20.
20. Tew JG, Thorbecke GJ, and Steinman RM (1982). Dentritic cells in the immune response: Characteristic and recommended nomenclature. J. Reticuloendothel. Soc31: 371–380.
21.
21. Van der Valk P, Te Velde J, Jansen J, Ruiter DJ, Spaander PJ, Cornelisse CJ, and Meijer CJLM (1981). Lymphoma of true histiocytic origin: Histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. Virchows Arch. Pathol. Anat391: 249–265.
22.
22. Van Furth R, Cohn ZA, Hirsch JG, Humphrey JH, Spector WG, and Langevoort HL (1972). The mononuclear phagocyte system: A new classification of macrophages, monocytes, and their precursor cells. Bull. World Health Organ46: 845–852.
23.
23. Vincent AL and Ash LR (1978). Further observations on spontaneous neoplasms in the Mongolian gerbil, Meriones unguiculatus. Lab. Anim. Sci28:297–300.
24.
24. Ward JM, Kulwich BA, Reznik G, and Berman JJ (1981). Malignant fibrous histiocytoma, an unusual neoplasm of soft tissue origin in the rat that is different from the human counterpart. Arch. Pathol. Lab. Med105: 313–316.
25.
25. Ward JM, Quander R, Devor D, Wenk ML, and Spangler EF (1986). Pathology of aging female SEN-CAR mice used as controls in the skin two-stage carcinogenesis studies. Environ. Health Perspect68:81–89.
26.
26. Weiss L (1991). Barrier cells in the spleen. Immunol Today21: 24–29.
