Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls. Based upon reduced body weight gains and survivals, the doses administered were considered to be toxic. It was concluded that the positive findings represented a class effect, and probably involved glucocorticoid receptors.
Cameron RG, Imaidi K., Tsuda H., and Ito N. (1982). Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine. Cancer Res. 42: 2426-2428.
2.
Goldfarb S. (1976). Sex hormones and hepatic neoplasia. Cancer Res. 36: 2584-2588.
3.
Harada I., Maronpot RR, Monis RW, and Boorman GA (1989). Observations on altered hepatocellular foci in National Toxicology Program two-year carcinogenicity studies in rats. Toxicol. Pathol. 17: 690-706.
4.
International Agency for Research on Cancer (1979). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 21, Sex Hormones (II), Lyon.
5.
Maronpot RR, Montgomery CA, Boorman GA, and Mc connell EE (1986). National toxicology program nomenclature for hepatoproliferative lesions of rats. Toxicol. Pathol. 14: 263-273.
6.
Schulte-Hermann R., Ochs H., Bursch W., and Parzefall W. (1988). Quantitative structure-activity studies on effects of sixteen different steroids on growth and monooxygenases of rat liver. Cancer Res. 48: 2462-2468.
