Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differences in the patterns of enzymes in various nephron segments. The subdivision of cells located in the mesangial region of the glomerulus into several types may provide new areas to study with respect to disease processes.
References
1.
1. Abrahamson DR and Caulfield JP (1985). Distribution of laminin within rat and mouse renal, splenic, intestinal, and hepatic basement membranes identified after intravenous injection of Heterologous antilaminin IgG. Lab. Invest.52:169–181.
3. Ausiello DA, Kreisberg JI, Roy C, and Karnovsky MJ (1980). Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with Angiotensin II and arginine vasopressin. J. Clin. Invest.65:754–760.
4.
4. Ballermann BJ, Skorecki KL, and Brenner BM (1984). Reduced glomerular Angiotensin II receptor density in early untreated diabetes mellitus in the rat. Amer. J. Physiol.16: F110–F116.
5.
5. Bankir L, Kaissling B, de Rouffignac C, and Kriz W (1979). Vascular organization of the kidney of Psammomys obesus. Anat. Embryol.155: 149–160.
6.
6. Bankir L, Biuby N, and Trink-Trang-Tan MM (1984). Organization of the medullary circulation and functional implications. In: Nephrology, RR Robinson (ed). Springer-Verlag, New York, Vol. I, pp. 84–106.
7.
7. Barfuss DW and Schafer JA (1984). Hyperosmolality of absorbate from isolated rabbit proximal tubules. Am. J. Physiol.247: F130–F139.
8.
8. Barrett JM, Kriz W, Kaissling B, and dc Rouffignac C (1978). The ultrastructure of the nephrons of the desert rodent (Psammomys obesus) kidney: II. Thin limbs of Henle of long-looped nephrons. Am. J. Anat.151:499–514.
9.
9. Barrett JM, Kriz W, Kaissling B, and de Rouffignac C (1978). The ultrastructure of the nephrons of the desert rodent (Psammomys obesus) kidney: I. Thin limb of Henle of short-looped nephrons. Am. J. Anat.151:487–498.
10.
10. Becker CG (1972). Demonstration of actomyosin in mesangial cells of renal glomerulus. Am. J. Pathol.66:97–110.
11.
11. Beeuwkes R III (1971). Efferent vascular patterns and early vascular-tubular relations in the dog kidney. Am. J. Physiol.221:1361–1374.
12.
12. Beeuwkes R III (1980). The vascular organization of the kidney. Ann. Rev. Physiol.42:521–542.
13.
13. Bengele HH, McNamara ER, and Alexander EA (1979). Potassium secretion along the inner medullary collecting duct. Am. J. Physiol.236: F278–F282.
14.
14. Blau EB and Haas JE (1973). Glomerular sialic acid and proteinuria in human renal disease. Lab. Invest.28:477–481.
15.
15. Bourdeau JEL and Burg MB (1980). Effect of PTH on calcium transport across the cortical thick ascending limb of Henle's loop. Am. J. Physiol.239: F121–F125.
16.
16. Brenner BM and Meyer TW (1984). Mechanisms of progression of renal disease. In: Nephrology, Proceedings of the IX International Congress of Nephrology, RR Robinson (ed). Springer-Verlag, New York, Vol. II, pp. 1233–1246.
17.
17. Burnick MD (1969). Contractile activity of human glomeruli in culture. Nephron6:1–10.
18.
18. Charbardes D, Imbert M, Clique A, Montegut M, and Morel F (1975). PTH-sensitive adenyl cyclase activity in different segments of the rabbit nephron. Pfluegers Arch.354:229–239.
19.
19. Cuppage FE and Tate A (1967). Repair of the nephron following injury with mercuric chloride. Am. J. Pathol.51:405–430.
20.
20. Dietrich HJ, Barrett JM, Kriz W, and Bulhoff JP (1975). The ultrastructure of the thin limbs of the mouse kidney. Anat. Embryol.147:1–18.
21.
21. Dobyan DC, Nagle RB, and Bulger RE (1977). Acute tubular necrosis in the rat kidney following sustained hypotension. Physiologic and morphologic observations. Lab. Invest.37:411–422.
22.
22. Dobyan DC, Levi J, Jacobs C, Kosek J, and Weiner MW (1980). Mechanism of cis-platinum nephrotoxicity: II. Morphological observations. J. Pharmacol. Exp. Ther.213:551–556.
23.
23. Dobyan DC, Magill LS, Friedman PA, Hebert SC, and Bulger RE (1982). Carbonic anhydrase histo-chemistry in rabbit and mouse kidneys. Anat. Rec.204:185–197.
24.
24. Dobyan DC and Jamison RL (1984). Structure and function of the renal papilla. Seminars in Nephrology4:5–26.
25.
25. Doucet A and Katz AI (1981). Mineralocorticoid receptors along the nephron: 3H aldosterone binding in rabbit tubules. Am. J. Physiol.241: F605–F611.
26.
26. Ernst SA (1975). Transport ATPase cytochemistry: Ultrastructural localization of potassium-dependent and potassium-independent phosphatase activities in rat kidney cortex. J. Cell Biol.66:586–608.
27.
27. Evan AP, Blomgren P, Knopp LC, and Tanner GA (1985). Proximal tubular morphology after single nephron obstruction in the rat kidney. Kidney Int.27:231A.
28.
28. Flamenbaum W, Hamburger RJ, Huddleston ML, Kaufman J, McNeil JS, Schwartz JH, and Nagle R (1976). The initiation phase of experimental acute renal failure. An evaluation of uranyl nitrate-induced acute renal failure in the rat. Kidney Int.10: S115–S122.
29.
29. Gertz KH, Schmidt-Nielsen B, and Pagel D (1966). Exchange of water, urea and salt between the mammalian renal papilla and the surrounding urine. Fed. Proc.25: 327.
30.
30. Glaumann B and Trump BF (1975). Studies on the pathogenesis of ischemic cell injury: III. Morphological changes of the proximal pars recta tubules (P3) of the rat kidney made ischemic in vivo. Virchows Arch. B (Cell Pathol.)19: 303–323.
31.
31. Glaumann B, Glaumann H, Berezesky IK, and Trump BF (1975). Studies on the pathogenesis of ischemic cell injury: II Morphological changes of the pars convoluta (P1 and P2) of the proximal tubule of the rat kidney made ischemic in vivo. Virchows Arch. B (Cell Pathol.)19: 281–302.
32.
32. Green R and Giebisch G (1984). Luminal hypotonicity: A driving force for fluid absorption from the proximal tubule. Am. J. Physiol.246: F167–F174.
33.
33. Greger R and Schlatter E (1981). Presence of luminal K+, a prerequisite for active NaCI transport in the cortical thick ascending limb of Henle's loop of rabbit kidney. Pflueger's Arch.392:92–94.
34.
34. Greger R, Schlatter E, and Lang F (1983). Evidence for electroneutral sodium chloride cotransport in the cortical thick ascending limb of Henle's loop of rabbit kidney. Pflueger's Arch.396:308–314.
35.
35. Gritzka TL and Trump BF (1968). Renal tubular lesions caused by mercuric chloride. Am. J. Pathol.52:1225–1278.
36.
36. Gross JB, Smai M, and Kokko JP (1975). A functional comparison of the cortical collecting tubule and the distal convoluted tubule. J. Clin. Invest.55:1284–1294.
37.
37. Haley DP (1982). Morphologic changes in uranyl nitrate induced acute renal failure in saline- and water-drinking rats. Lab. Invest.46:196–208.
38.
38. Hall DA and Varney D (1979). Effect of vasopressin on chloride transport by mouse medullary thick ascending limbs of Henle's loop perfused in vitro. Kidney Int.16: 818 (Abstract).
39.
39. Hall DA and Varney DM (1980). Effect of vasopressin on electrical potential difference and chloride transport in mouse medullary thick ascending limb of Henle's loop. J. Clin. Invest.66:792–802.
40.
40. Harmanci MC, Stern P, Kachadorian WA, and Valtin H (1980). Vasopressin and collecting duct intra-membranous particle clusters: A dose response relationship. Am. J. Physiol.239: F560–F564.
41.
41. Harmanci MC, Kachadorian WA, Valtin H, and DiScala VA (1978). Antidiuretic hormone-induced intramembranous alterations in mammalian collecting ducts. Am. J. Physiol.235: F440–F443.
42.
42. Hebert SC, Culpepper RM, and Andreoli TE (1981). ADH-stimulated NaCl transport in mouse medullary thick ascending limbs. 1. Evidence for ADH-stimulated neutral NaCl co-transport and functional nephron heterogeneity. Am. J. Physiol.241: F412–F431.
43.
43. Hierholzer K (1961). Secretion of potassium and acidification in collecting ducts of mammalian kidneys. Am. J. Physiol.201:318–324.
44.
44. Imai M (1979). The connecting tubule: A functional subdivision of the rabbit distal nephron segments. Kidney Int.15:346–356.
45.
45. Kaissling B (1982). Structural aspects of adaptive changes in renal electrolyte excretion. Am. J. Physiol.243: F211–F226.
46.
46. Kaissling B and Kriz W (1979). Structural analysis of the rabbit kidney. Adv. Anal. Embryol. Cell Biol.56:1–123.
47.
47. Kaissling B and Le Hir M (1982). Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake. I. Structural changes. Cell Tissue Res.224:469–492.
48.
48. Kaissling B, de Rouffignac C, Barrett JM, and Kriz W (1975). The structural organization of the kidney of the desert roden. Psammomys obesus. Anat. Embryol.148: 121–143.
49.
49. Kaissling B, Bachmann S, and Kriz W (1985). Structural adaptation of the distal convoluted tubule to prolonged furosemide treatment. Am. J. Physiol.248: F374–F381.
50.
50. Kanwar YS and Farquhar MG (1979). Anionic sites in the glomerular basement membranes. In vivo and in vitro localization to the laminae rarae by cationic probe. J. Cell Biol.81:137–153.
51.
51. Kanwar YS, Linker A, and Farquhar MG (1980). Increased permeability of the glomerular basement membrane to ferritin after removal of glycosami-noglycans (heparan sulfate) by enzyme digestion. J. Cell Biol.86:688–693.
52.
52. Kanwar YS and Rosenzweig LJ (1982). Altered glomerular permeability as a result of focal detachment of the visceral epithelium. Kidney Int.21:565–574.
53.
53. Kerjaschki D, Sharkey DJ, and Farquhar MG (1984). Identification and characterization of podocalyxin—The major sialoprotein of the renal glomerular epithelial cell. J. Cell Biol.98:1591–1596.
54.
54. Kerjaschki D, Noronha-Blob L, Sacktor B, and Farquhar MG (1984). Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush border. J. Cell Biol.98:1505–1513.
55.
55. Kerjaschki D, Vemillo AT, and Farquhar MG (1985). Reduced sialylation of podocalyxin—the major sialoprotein of the rat kidney glomerulus—in aminon-uclcosidc nephrosis. Am. J. Path.118:343–349.
56.
56. Kone BC, Madsen KM, and Tisher CC (1984). Ultrastructure of the thick ascending limb of Henle in the rat kidney. Am. J. Anat.171:217–226.
57.
57. Kreisberg JI (1983). Contractile properties of the glomerular mesangium. Fed. Proc.42:3053–3057.
58.
58. Kreisberg JI, Venkatachalam MA, and Patel PY (1984). Cyclic AMP-associated shape change in mesangial cells and its reversal by prostaglandin E2. Kidney Int.25:874–879.
59.
59. Kriz W (1983). Structural organization of the renal medullary counterflow system. Fed. Proc.42:2379–2385.
60.
60. Kriz W, Schnermann J, and Dietrich HJ (1972). Differences in the morphology of descending limbs of short and long loops of Henle in the rat kidney. In: Recent Advances in Renal Physiology, W Kriz and F Spinelli (eds). S. Karger, Basel, pp 140–144.
61.
61. Kriz W, Kaissling B, and Pszolla M (1978). Morphological characterizations of the cells in Henle's loop and the distal tubule. In: New Aspects of Renal Function, HG Vogel and KJ Ullrich (eds). Excerpta Medica, Amsterdam/Oxford, pp. 67–79.
62.
62. Kriz W and Koepsell H (1974). The structural organization of the mouse kidney. Z. Anat. Entwickl.-Gesch.144:137–163.
63.
63. Lacy ER (1980). The mammalian renal pelvis: Physiological implications from morphometric analyses. Anat. Embryol.160:131–144.
64.
64. Leonard SL and Jamison RL (1983). Exchange of water and solute between the mammalian renal papilla and surrounding urine. Clin. Res.31: 516A.
65.
65. Liu F, Cogan MG, and Rector FC Jr (1984). Axial heterogeneity in the rat proximal convoluted tubule. II. Osmolality and osmotic water permeability. Am. J. Physiol.247: F822–F826.
66.
66. Madri JA, Roll FJ, Furthmayr H, and Foidart JM (1980). Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. J. Cell Biol.86:682–687.
67.
67. Madsen KM and Tisher CC (1983). Cellular response to acute respiratory acidosis in rat medullary collecting duct. Am. J. Physiol.245: F670–F679.
68.
68. Madsen KM and Tisher CC (1984). Response of intercalated cells of rat outer medullary collecting duct to chronic metabolic acidosis. Lab. Invest.51: 268.
69.
69. Majack RA, Paull WK, and Barrett JM (1979). The ultrastructural localization of membrane ATPasc in rat thin limb of the loop of Henle. Histochemistry63:23–33.
70.
70. Marver D (1984). Evidence of corticosteroid action along the nephron. Am. J. Physiol.246: F111–F123.
71.
71. Maunsbach AB (1966). Observations on the segmentation of the proximal tubule in the rat kidney. Comparison of results from phase contrast-fluorescence and electron microscopy. J. Ultrastruct. Res.16:239–258.
72.
72. Mernissi GE and Doucet A (1984). Quantitation of 3H ouabain binding and turnover of Na-K-ATPase along the rabbit nephron. Am. J. Physiol.247: F158–F167.
73.
73. Michael AF, Blau E, and Vernier RL (1970). Glomerular polyanion: Alterations in aminonucleoside nephrosis. Lab. Invest.23:649–657.
74.
74. Morel F (1981). Sites of hormone action in the mammalian nephron. Am. J. Physiol.240: F159–F164.
75.
75. Nagle RB, Altschuler EM, Dobyan DC, Dong S, and Bulger RE (1981). The ultrastructure of the thin limbs of Henle in kidneys of the desert heteromyid (Perognathus penicillatus). Am. J. Anal.161:33–47.
76.
76. Neiss WF (1982). Morphogenesis and histogenesis of the connecting tubule in the rat kidney. Anat. Embryol.165:81–95.
77.
77. Oliver J (1968). Nephrons and Kidneys.Harper & Row, New York, p. 117.
78.
78. Peter K (1927). Untersuchungen über Bau and Ent-wicklung der Niere. V. Die Entwicklung der Menschlichen Niere nach Isolationspraparaten. IV. Der Ausbau der Nierensubstanz. Fischer, Jena. Vol. 2: 522–647.
79.
79. Pfeiffer EW (1968). Comparative anatomical observations of the mammalian renal pelvis and medulla. J. Anat.102:321–331.
80.
80. Potter EL (1972). Normal and Abnormal Development of the Kidney.Year Book Medical Publishers, Chicago.
81.
81. Rastegar A, Biemesderfer D, Kashgarian M, and Hayslett JP (1980). Changes in membrane surfaces of collecting duct cells in potassium adaptation. Kidney Int.18:293–301.
82.
82. Roll FJ, Madri JA, Albert J, and Furthmayr H (1980). Codistribution of collagen type IV and AB2 in the basement membranes and mesangium of the kidney. J. Cell Biol.85:597–616.
83.
83. Sasaki S and Imai M (1980). Effects of vasopressin on water and NaCl transport across the in vitro perfused medullary thick ascending limb of Henle's loop of mouse, rat, and rabbit kidneys. Pflueger's Arch.383:215–221.
84.
84. Schafer JA (1984). Mechanisms coupling the absorption of solutes and water in the proximal nephron. Kidney Int.25:708–716.
85.
85. Schmidt U and Dubach UC (1971). Na-K-ATPase in the rat nephron related to sodium transport: Results with quantitative histochemistry. Part II. In: Recent Advances in Quantitative Histo- and Cytochemistry. Methods and Applications, UC Dubach and U Schmidt (eds). Huber, Publishers, Bern, pp. 320–344.
86.
86. Schmidt-Nielsen B (1977). Excretion in mammals: Role of the renal pelvis in the modification of the urinary concentration and composition. Fed. Proc.36:2493–2503.
87.
87. Schmidt-Nielsen B, Churchill M, and Reinking LN (1980). Occurrence of renal pelvic refluxes during rising urine flow rates in rats and hamsters. Kidney Int.18:419–431.
88.
88. Schmidt-Nielsen B, Barrett JM, Graves B, and Crossley B (1985). Physiological and morphological responses of the rat kidney to reduced dietary protein. Am. J. Physiol.248: F31–F42.
89.
89. Schor N, Ichikawa I, Rennke HG, Troy JL, and Brenner BM (1981). Pathophysiology of altered glomerular function in aminoglycoside-treatcd rats. Kidney Int.19:288–296.
90.
90. Schreiner GF and Unanue ER (1984). Origin of the rat mesangial phagocyte and its expression of the leukocyte common antigen. Lab. Invest.51:515–523.
91.
91. Schreiner GF, Cotran RS, and Unanue ER (1984). Modulation of Ia and leukocyte common antigen expression in rat glomeruli during the course of glomerulonephritis and aminonucleoside nephrosis. Lab. Invest.51:524–533.
92.
92. Schutz W and Schnermann J (1972). Pelvic urine composition as a determinant of inner medullary solute concentration and urine osmolality. Pfluegers Arch.334:154–166.
93.
93. Schwartz MM and Venkatachalam MA (1974). Structural differences in thin limbs of Henle: Physiological implication. Kidney Int.6:193–208.
94.
94. Schwartz MM, Karnovsky MJ, and Venkatachalam MA (1979). Regional membrane specializations in the thin limbs of Henle's loops as seen by freeze-fracture electron microscopy. Kidney Int.16:577–589.
95.
95. Seiler MW, Venkatachalam MA, and Cotran RS (1975). Glomerular epithelium: Structural alterations induced by polycations. Science189:390–393.
96.
96. Seiler MW, Rennke HG, Venkatachalam MA, and Cotran RS (1977). Pathogenesis of polycation-induced alterations (“fusion”) of glomerular epithelium. Lab. Invest.36:48–61.
97.
97. Smith HW (1956). Principles of Renal Physiology.Oxford University Press, New York.
98.
98. Sraer JD, Sraer J, Ardaillou R, and Mimoune O (1974). Evidence for renal glomerular receptors for angiotensin II. Kidney Int.6:241–246.
99.
99. Stanton BA, Biemesderfer D, Wade JB, and Giebisch G (1981). Structural and functional study of the rat distal nephron: Effects of potassium adaptation and depletion. Kidney Int.19:36–48.
100.
100. Stein JH, Gottschall J, Osgood RW, and Ferris TF (1975). Pathophysiology of a nephrotoxic model of acute renal failure. Kidney Int.8:27–41.
101.
101. Stetson DL, Wade JB, and Giebisch G (1980). Morphologic alterations in the rat medullary collecting duct following potassium depletion. Kidney Int.17:45–56.
102.
102. Suki WN, Rouse D, Ng RCK, and Kokko JP (1980). Calcium transport in the thick ascending limb of Henle. Heterogeneity of functions in the medullary and cortical segments. J. Clin. Invest.66:1004–1009.
103.
103. Venkatachalam MA, Bernard DB, Donohoe JF, and Levinsky NG (1978). Ischemic damage and repair in the rat proximal tubule. Differences among the S1, S2 and S3 segments. Kidney Int.14:31–49.
104.
104. Venkatachalam MA, Jones DB, Rennke HG, Sand-strom D, and Patel Y (1981). Mechanism of proximal tube brush border loss and regeneration following mild renal ischemia. Lab. Invest.45:355–365.
105.
105. Wade JB, O'Neil RG, Pryor JL, and Baulpaep EL (1979). Modulations of cell membrane area in renal collecting tubules by corticosteroid hormones. J. Cell Biol.81:439–445.
106.
106. Woodhall PB and Tisher CC (1973). Response of the distal tubule and cortical collecting duct to vasopressin in the rat. J. Clin. Invest.52:3095–3108.
107.
107. Woodhall PB, Tisher CC, Simonton CA, and Robinson RR (1978). Relationship between para-aminohippurate secretion and cellular morphology in rabbit proximal tubules. J. Clin. Invest.61:1320–1329.
108.
108. Yamamoto K, Wilson DR, and Baumal R (1984). Blood supply and drainage of the outer medulla of the rat kidney: Scanning electron microscopy of microvascular casts. Anat. Rec.210:273–277.
