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Abstract

The purpose of this presentation is to determine the prognostic role of cellular morphology in animal neoplasia. With some exceptions, cellular morphology is the single most accurate predictor of the prospective behavior of neoplasms. There is generally a positive correlation between the degree of malignancy and prognosis. The exceptions are a) morphologically malignant-appearing tumors following a benign course (e.g., canine histiocytoma, canine seminoma, equine sarcoid) and b) morphologically differentiated tumors exhibiting an unpredictable prognosis (e.g., canine pericytoma, acanthomatous epulis, myxoma, follicular thyroid cell carcinoma, etc.). Anaplasia, an important characteristic of most malignant neoplasms, may be less stable than generally assumed. Sodium butyrate may reverse it intermittently and anaplastic gliomas may loose all morphologic and cytokinetic characteristics of anaplasia following sodium butyrate exposure. Host factors, such as nerve growth factor, have similar and more lasting effects upon anaplastic cells derived from the neural crest. Such factors may act as reverse transformation agents and may represent prospective therapeutic agents for anaplastic tumors.

References

1. Fowler EH , Wilson GP , and Koestner A (1974). Biological behavior of canine mammary neoplasms based on a histogenetic classification. Vet. Pathol. 11: 212–229.

2. Ko L-W , Koestner A , and Wechsler W (1980). Morphological characterization of nitrosourea-induced glioma cell lines and clones. Acta Neuropathol. (Berl.) 1: 23–31.

3. Ko L-W , Koestner A , and Wechsler W (1980). Characterization of cell cycle and biological parameters of transplantable glioma cell lines and clones. Acta Neuropathol. (Berl.) 51: 107–111.

4. Ko L-W , and Koestner A (1980). Morphologic and morphometric analyses of butyrate-induced alterations of rat glioma cells in vitro. J. Nail. Cancer Institute 65: 1017–1027.

5. Koestner A , Swenberg JA , and Wechsler W (1972). Experimental tumors of the nervous system induced by resorptive N-nitrosourea compounds. Prog. Exp. Tumor Res. 17: 9–30.

6. Nieburg HE (1983). Prognostic role of tumor cell morphology prior to and during chemotherapy. Proceedings of the 13th International Congress of Chemotherapy, Vienna, Austria, Part 258: 12–16.

7. Swenberg JA , Wechsler W , and Koestner A (1972). The sequential development of transplacentally induced neuroectodermal tumors. J. Neuropathol. Exp. Neurol. 31: 202–203.

8. Swenberg JA , Clendenon N , Denlinger R , and Gordon WA (1975). Sequential development of ethyl-nitrosourea-induced neurinomas: Morphology, biochemistry, and transplantability. J. Natl. Cancer Inst. 55: 147–152, 1975.

9. Vinores SA , and Koestner A (1980). The effect of nerve growth, factor on undifferentiated glioma cells. Cancer Lett. 10: 309–318.

10.

10. Vinores SA , and Koestner A (1982). Reduction of ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves by nerve growth factor. Cancer Res. 42: 1038–1040.

11.

11. Vinores SA , and Guroff G (1980). Nerve growth factor: mechanism of action. Annu. Rev. Biophys. Bioeng. 9: 223–257.

Prognostic Role of Cell Morphology of Animal Tumors

Abstract

References