Lambda-Carrageenan, a food additive, injected into the yolk sac of fertile chicken eggs had teratogenic and lethal effects on chick embryo development. Anomalies were mainly localized in the cephalic end (exencephaly, abnormal beak, anophtalmy, etc.). All abnormal chicks of the group injected with carrageenan showed two or more anomalies. Growth of newborn chicks in the carrageenan-injected group was significantly diminished until the 4th day of age.
References
1.
1. Abraham R, Fabian RJ, Golberg L, Role of lysosomes in carrageenan-induced cecal ulceration. Gastróenterology67:1169–1181, 1974.
2.
2. Beck F: The distribution of acid phosphatase in the chick blastoderm.Exp Cell Res37:504–508, 1965.
3.
3. Brummett ES, Johnson EM: Morphological alterations in the developing fetal rat limb due to maternal injection of Chlorambucil.Teratology20:279–288, 1979.
4.
4. Burk DT, Sadler TW: Surface coat formation during lip and neural tube formation in mouse embryos. Anat Rec190:351, 1978.
5.
5. Catanzaro PJ, Schwartz HJ, Graham RC: Spectrum and possible mechanism of carrageenan cytotoxicity.Am J Pathol64:387–404, 1971.
6.
6. Chen WJ, Body RL, Mottet NK: Some effects of continuous low-dose congenital exposure to methylmercury on organ growth in the rat fetus.Teratology20:31–36, 1979.
7.
7. Collins TFX, Black TN, Prew JH: Long-term effects of calcium carrageenan in rats. I. Effects on reproduction.Food Cosmet Toxicol15:533–538, 1977.
8.
8. Collins TFX, Black TN, Prew JH: Long-term effects of calcium carrageenan in rats. II. Effects on Foetal development.Food Cosmet Toxicol15:539–545, 1977.
9.
9. Demeyer R: Action teratogene du galactose administre a la rate gravide. Ann Endocrinol (Paris)20:203–211, 1959.
10.
10. Food and Drug Research Laboratories, Inc. Teratologic evaluation of calcium carrageenate (FDA 71-5) in mice, rats, hamsters and rabbiets. National Technical Information Service, Springfield, VA, 1973.
11.
11. Food and Drug Research Laboratories, Inc. Teratologic evaluation of sodium carrageenate (FDA 71-3) in mice, rats, hamsters, and rabbiets. National Technical Information Service, Springfield, VA, 1973. (PB-221 812)
12.
12. Hallas BH, Das GD: An aberrant nucleus in the telencephalon following administration of ENU during neuroembryogenesis.Teratology19:159–164, 1979.
13.
13. Hamburger V, Hamilton HL: A series of normal stages in the development of the chick embryo.J Morphol88:49–92, 1951.
14.
14. Hughes AF, Freeman RB, Fadem T: The teratogenic effects of sugars on the chick embryo.J Embryol Exp Morphol32:661–674, 1974.
15.
15. Kimmel GL, Hartwell BS, Andrew FD: A potential mechanism in medroxyprogesterone acetate teratogenesis.Teratology19:171–176, 1979.
16.
16. Kochhar DM, Penner JD, Knudsen TB: Embryotoxic, teratogenic, and metabolic effects of Ribavirin in mice.Toxicol Appl Pharmacol52:99–112, 1980.
17.
17. Lee HY, Sheffield JB, Nagele RG Jr: The role of extracellular material in chick neurulation. II. Surface morphology of neuroepithelial cells during neural fold fusion.J Exp Zool204:937–154, 1978.
18.
18. McLean RJ: Membrane specialization in the course of differentiation in Mammalian Cell Membranes. Jamieson GA, Robinson DM, eds. Butterworths-Boston, vol. 3, pp. 250-265, 1977.
19.
19. Meller SM, Barton LH: Extracellular coat in developing human palatal processes: electron microscopy and ruthenium red binding.Anat Rec190:223–232, 1978.
20.
20. Monis B, Weinberg T, Spector GJ: The carrageenan granuloma in the rat. A model for the study of the structure and function of macrophages.Br J Exp Pathol49:302–310, 1968.
21.
21. Monis B, Valentich MA: Secondary lysosomes of macrophages: structure and biochemistry.Acta Physiol Latinoam23:667–669, 1973.
22.
22. Moscona AA, Hausman RE: Biological and biochemical studies on embryonic cell-cell recognition in Cell and Tissue Interactions. Lash JW, Burger MM, eds. Raven Press, New York, pp. 173–185, 1977.
23.
23. Murray FJ, Staples RE, Schwetz BA: Teratogenic potential of carbaryl given to rabbits and mice by gavage or by dietary inclusion.Toxicol Appl Pharmacol51:81–89, 1979.
24.
24. Nineteenth Annual Meeting of Congenital Anomalies Research Association of Japan. July 1979. Teratology 20:139–188, 1979.
25.
25. Nineteenth Annual Meeting of Teratology Society. June 1979. Teratology 19:1A–55A. 1979.
26.
26. Pittz EP, Jones R, Golberg L, and Coulston F: Interaction of polysaccharides with plasma membranes. I. Interaction of human erythrocytes with degraded iota carrageenans and the effect of dextran and deae dextran.Biorheology24:21–31, 1977.
27.
27. Pittz EP, Jones R, Golberg L, and Coulston F: Interaction of sulfated polysaccharides with plasma membranes. II. Effect of ionic strength, temperature, and trypsin digestion of the erythrocyte surface on the aggregation of erythrocytes by iota carrageenans.Biorheology14:33–42, 1977.
28.
28. Roth S, McGuire EJ, Roseman S: Evidence for cell-surface glycosyltransferases: their potential role in cellular recognition.J Cell Biol51:536–547, 1971.
29.
29. Rovasio RA, Monis B: Teratogenic effect of lambda-carrageenan on chick embryo.Rev Micr Electr5:52–53, 1978.
30.
30. Shepard TH: Catalog of Teratogenic Agents. Johns Hopkins University Press, Baltimore, 1973.
31.
31. Shur BD: Cell-surface glycosyltransferases in gastrulating chick embryos. I. Temporally and spatially specific patterns of four endogenous glycosyltrans-ferase activities.Dev Biol58:23–39, 1977.
32.
32. Shur BD: Cell-surface glycosyltransferases in gastrulating chick embryos. II. Biochemical evidence for a surface localization of endogenous glycosyltransfer-ase activities.Dev Biol58:40–55, 1977.
33.
33. Tarr HLA: Sea Foods in Handbook of Food and Agriculture. Blank FC, ed. Reinhold Publ. Co., New York, pp. 511–531, 1955.
34.
34. Thomson AW, Wilson AR, Cruickshank WJ, et al: Evidence for a selective cytotoxic effect of carrageenan on cells of the immune system in vivo and in vitro.Experientia32:525–526, 1976.