Pardo ID, Weber K, Cramer S, Krinke GJ, Butt MT, Sharma AK, Bolon B (2020). Atlas of normal microanatomy, procedural and processing artifacts, common background findings, and neurotoxic lesions in the peripheral nervous system of laboratory animals. Toxicol Pathol 48(1): 105-131. (Original DOI: 10.1177/0192623319867322)
In this article, the image and legend for Figure 67 do not match in the original OnlineFirst and online issue versions. The correct combination of image and legend for Figure 67 is:
Laminar accumulation of Schwann cells (“hypertrophic neuropathy”) in the phrenic nerve. Affected nerve fibers exhibit concentric layers (termed “onion bulbs”) of Schwann cells intermingled with collagen surrounding intact pale, central axons. The variable but usually marked thinning of the dark myelin sheaths stems from repeated cycles of myelin degeneration and regeneration. Species: Adult Pmp22Tr-J (“Trembler”) mouse. Processing: 2.5% glutaraldehyde immersion, plastic, Toluidine blue. [This image was provided courtesy of Dr. Lucia Notterpek, University of Nevada, Reno and is reproduced from Zhou Y, et al., “A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice,” Exp Neurol. 2019;321:113031, with the permission of Elsevier.]
The image shown in the original OnlineFirst and online issue versions does represent a peripheral nervous system (PNS) finding that was not specifically described in the original atlas. The appropriate combination of image and legend for this finding is:
Axonal regeneration in a sciatic nerve. Clusters of small, thinly myelinated axons (arrows) are shown in a cross section located distal to a site of nerve injury. This appearance arises from the initial distal extensions from multiple viable axons. Species: Cynomolgus monkey. Processing: 4% paraformaldehyde perfusion followed by 2% paraformaldehyde/2.5% glutaraldehyde immersion fixation (for 48 hours), osmium post-fixation, resin embedding, Toluidine blue stain.
