Society of Toxicologic Pathology’s 28 th Annual Symposium Poster Presentations

P-1 Hepatocholangiocarcinomas In B6C3F1 Mice

Rebecca Moore¹, Gabrielle Willson¹, David Malarkey², Rodney Miller¹, Grace Kissling³, ¹Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, United States, ²Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States, ³Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States

P-2 Predicting Rat Carcinogenicity Findings Using Chronic Study Results

Susan Turnquist¹, Daniel Morton¹, ¹Pfizer Inc, Groton, CT, United States

P-3 Reported Medulloblastoma in the F344 Rat: National Toxicology Program (NTP) Experience

Deepa Rao¹, James Morrison², Hiroshi Satoh³, David Malarkey¹, ¹National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States, ²Charles River Laboratories, Pathology Associates, Durham, North Carolina, United States, ³Ina Research Inc., Tokyo, Japan

P-4 A Comparison of the Effects of the Rodent Liver Carcinogens on Rat Liver under ad libitum Feeding and Food Restriction

Takayuki Tsuchiya¹, Chie Okumura¹, Hiroki Sugiura¹, Forest Thomas², Minoru Sasaki1, Gordon Wollenberg², Prahalada Srinvasa², ¹Banyu Pharmaceutical Co., Ltd., Tsukuba, Japan, ²Merck Research Laboratories, West Point, United States

P-5 Diuron and Mice Skin Carcinogenesis

Bianca Ferrucio^1,2, Carla Adriene Franchi1,², Maria Luiza Cotrim de Oliveira^1,2, Deilson Elgui de Oliveira^1,3, João Lauro Viana de Camargo^1,2, ¹São Paulo State University (UNESP) - Botucatu Medical School, Deparment of Pathology, Botucatu, SP, Brazil, ²TOXICAM Laboratory, Botucatu, SP, Brazil, ³Molecular Pathology Laboratory, Botucatu, SP, Brazil

P-6 Naturally Occurring Bladder Papilloma and Large Granular Lymphocyte Leukemia in an Aging Male Wistar Rat

Chien-Chao Chiu¹, Hsiao-Li Chuang², Yen-Te Huang¹, Kinji Shirota³, Hans Hsien-Chuan Chen⁴, ¹National Laboratory Animal Center, National Applied Research Laboratories, Taipei, Taiwan, ²Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan, ³Research Institute of Biosciences, Azabu University, Sagamihara, Japan, ⁴HansChen BiotechPath Consulting, Taipei, Taiwan

P-7 Effect Of Zoledronic Acid Therapy In An In Vivo Model Of Bone Invasive Feline Oral Squamous Cell Carcinoma

Chelsea Martin¹, Jillian Werbeck¹, Nandu Thudi¹, Lisa Lanigan¹, Tobie Wolfe¹, Ramiro Toribio¹, Thomas Rosol¹, ¹The Ohio State University, Columbus, Ohio, United States

P-8 Dose-Response Study Of Diuron [3-(3,4-Dichlorophenyl)-1, 1-Dimethylurea]-Induced Toxicity Of The Urinary Bladder In Male Wistar Rats

Shadia Ihlaseh¹, Ana Paula Cardoso¹, Mitscheli Da Rocha¹, Merielen Nascimento¹, Maria Luiza De Oliveira¹, João Lauro De Camargo¹, ¹Sao Paulo State University, Botucatu Medical School, Department of Pathology, Botucatu, SP, Brazil

P-9 A Novel Pan-HDAC Inhibitor, OSU-HDAC42 Exhibits Biological Effects Against Canine and Human Malignant Mast Cells via Histone and Kit Dependent Pathways

Tzuyin Lin¹, Sridhar Murahari¹, Samuel Kulp¹, Dasheng Wang¹, Ching-Shih Chen¹, William Kisseberth¹, Cheryl London¹, ¹Ohio state University, columbus, OH, United States

P-10 Hepatocellular Carcinoma in Genetically Obese Mice

Hyojung Kwon^1,2, Youngsuk Won¹, Hyoungchin Kim1, Daeyong Kim², ¹KRIBB, Chungbook, Korea, Republic of, ²Department of Veterinary Pathology, College of Veterinary Medicine,Seoul National University, Seoul, Korea, Republic of

P-11 Preclinical investigation of novel indole-3-carbinol analogs for the prevention and treatment of prostate cancer

Aaron Sargeant¹, Chen-Hsun Tsai¹, Alene Yeater², Samuel Kulp1, Lisa Berman-Booty1, Robert Rengel¹, Steven Clinton¹, Dasheng Wang¹, Ching-Shih Chen¹, ¹The Ohio State University, Columbus, Ohio, United States, ²University of Toledo Medical Center, Toledo, Ohio, United States

P-12 Proteomic Profiling Of Multiple Myeloma Cells Following a High Dose Of Melphalan

Sheeno Thyparambil¹, Veronica MacLeod¹, John Shaughnessy¹, Ricky Edmondson¹, ¹University of Arkansas for Medical Sciences, Little Rock, AR, United States

P-13 Stable overexpression of DeltaNp63a blocks senescence and promotes malignant transformation in keratinocytes

Linan Ha¹, Roshini Ponnamperuma¹, Wendy Weinberg¹, ¹DMA/OBP/OPS/FDA, Bethesda, MD, United States

P-14 Zoledronic Acid inhibits Osteolysis in a Nude Mouse Model of Canine Prostate Cancer Mixed Bone Metastases

Nanda Thudi¹, Chelsea Martin¹, Prasad Nadella¹, Soledad Fernandez¹, Jillian Werbeck¹, Joseph Pinzone¹, Thomas Rosol¹, ¹The ohio state university, Columbus, oh, United States

P-15 A High Dose of Genistein Induces Cell Death in Uterine Leiomyoma Cells by Autophagy and not by Apoptosis

Lysandra Castro¹, Linda Yu¹, Alicia B. Moore¹, Grace E. Kissling¹, Retha R. Newbold¹, Darlene Dixon¹, ¹National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States

P-16 Identification Of Unique Chromosomal Alterations In Primary and Metastatic Pancreatic Ductal Tumors Derived From Transgenic Mice By Array-Comparative Genomic Hybridization (aCGH)

Melissa Schutten¹, Adam Jochem¹, Eric Sandgren¹, ¹University of Wisconsin-Madison, Madison, WI, United States

P-17 Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis

Tanasa Osborne^1,2, Ling Ren¹, Wanda Haschek-Hock², Stephen Hewitt³, Chand Khanna¹, ¹Tumor and Metastasis Biology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States, ²Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Tissue Array Research Program (TARP), Rockville, MD, United States

P-18 Evaluation of Automated Histology Pattern Recognition Tool for Selection and Analysis of Tumor Regions in Breast Sections Stained with ER, PR and Ki67

Kate Lillard-Wetherell¹, ¹Aperio, Vista, CA, United States

P-19 Impact of Post Translational Modifications on the Function of of HTLV-1 p30

Nadine Bowden¹, Rajaneesh Anupam¹, Matt Kesic¹, Michael Lairmore¹, ¹The Ohio State University, Columbus, OH, United States

P-20 Development Of An In-Vivo Bioluminescent Mouse Model of Prostate Cancer Metastasis

Philip Martin¹, Rachel Pierce¹, Kathleen Kelly¹, ¹National Institutes of Health (NCI), Bethesda, Maryland, United States

P-22 Localization Of ALT Isozymes In Beagle Dogs: An Immunohistochemical Study

Yuichi Takai¹, Yusuke Sudo¹, Kazuko Hirai¹, Masami Aoki¹, Ryo Fukuda¹, Kenji Takami¹, ¹Takeda Pharmaceutical Company Limited, Osaka, Japan

P-23 Spontaneous Glomerulonephritis in Four Göttingen Minipigs

Enrico Vezzali¹, Rosa Anna Manno¹, Yuval Ramot², Abraham Nyska^3,4, ¹R.T.C. – Research Toxicology Centre S.p.A., Pomezia, Rome, Italy, ²Hadassah – Hebrew University Medical Center, Jerusalem, Israel, ³Consultant in Toxicological Pathology, Timrat, Israel, ⁴Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

P-24 Atypical Cellular Infiltrates In Mouse And Rat Liver Following Treatment With A Pan-caspase Inhibitor

Kathryn Gropp¹, Daniel Morton¹, Frances Clemo¹, John Kreeger¹, Bernard LeBlanc², Thomas Kawabata¹, Daniel Lettiere¹, Kathleen White³, William Brown³, Tim Coskran¹, ¹Pfizer, Inc., Groton, CT, United States, ²Pfizer, Inc., Amboise, France, ³Pfizer, Inc., Kalamazoo, MI, United States

P-25 Histology Atlas of the Developing Mouse Hepatobiliary System

Laura Wilding¹, Julie Foley², Susan Elmore², ¹North Carolina State College of Veterinary Medicine, Raleigh, NC, United States, ²National Institute of Environmental Health Sciences, Cellular and Molecular Pathology Branch, Research Triangle Park, NC, United States

P-26 Degenerative Renal Tubular Lesions in F344N Rats Exposed to β-Myrcene

Mark F. Cesta², Robert C. Sills², Po Chan¹, ¹Toxicology Operations Branch, NTP, NIEHS, NIH, DHHS, Research Triangle Park, NC, United States, ²Cellular and Molecular Pathology Branch, NTP, NIEHS, NIH, DHHS, Research Triangle Park, NC, United States

P-27 Role of CYP1C1 and CYP1A Expression in PAH Induced Fundulus Hepatic Lesions

Lu Wang¹, Alvin Camus², Cammi Thornton¹, Wu Dong¹, Kristine Willett¹, ¹University of Mississippi, University, MS, United States, ²University of Georgia, Athens, GA, United States

P-28 Uterine Trophoblastic Tumors in Macaques

Sunish Mohanan¹, Jennifer Cann¹, Hermina Borgerink¹, Justin D. Vidal², Ross P. Tarara³, J. Mark Cline¹, ¹Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States, ²GlaxoSmithKline, King of Prussia, PA, United States, ³California National Primate Research Center, UC Davis, Davis, CA, United States

P-29 Influence Of Diuron On The Rat Urinary Bladder Mucosa: An Urinary Acidification Study

Mitscheli Da Rocha¹, Merielen Nascimento¹, Ana Paula Cardoso¹, Ednéia Zelandi¹, João Lauro De Camargo¹, Maria Luiza De Oliveira¹, ¹São Paulo State University - UNESP, Botucatu Medical School, Department of Pathology, TOXICAM laboratory, Botucatu/São Paulo, Brazil

P-30 Glomerulonephropathy Induced by Bolus Injection with Dibasic Phosphate Solution in Sprague-Dawley Rats

Noriko Tsuchiya¹, Mikinori Torii¹, ¹Shionogi Co., Ltd., Toyonaka, Osaka, Japan

P-31 Hepatotoxic Effect Of TCPOBOP Correlates With Constitutive Androstane Receptor Activation In Mice

Heidge Fukumasu^1,3, Gabriel Anhé², Daniel Soares Sanches¹, Leonila Ester Reinert-Raspantini¹, Silvana Bordin², Jerrold M. Ward⁴, Maria Lucia Dagli¹, ¹Faculty of Veterinary Medicine and Animal Sciences - University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ²Institute of Biomedical Sciences - University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ³Faculty of Animal Science and Food Engineering - University of Sao Paulo, Pirassununga, Sao Paulo, Brazil, ⁴Global VetPathology, Montgomery Village, Maryland, United States

P-32 A possible implication of thioredoxin in liver regeneration

Byung-Il Yoon^1,3, Mi-Sun Park², Yong-Baek Kim³, Jeong-Hee Han¹, Dae-Yong Kim⁴, ¹School of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon-do, Korea, Republic of, ²National Cancer Center, Goyang, Kyunggi-do, Korea, Republic of, ³College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States, ⁴College of Veterinary Medicine, Seoul National University, Seoul, Korea, Republic of

P-33 Metabolomics Analysis of Urine and Kidney Tissue in Rats Treated with Valproate

Kurt Boudonck¹, Kirk Beebe¹, ¹Metabolon, Research Triangle Park, NC, United States

P-34 Repeated Dose Oral Toxicity Study of Febuxostat In Sprague Dawley Rats

Praful Patel¹, Vijay Patel¹, K.S. Prajapati¹, Rajesh Sunder¹, Mukul Jain¹, Pankaj Patel¹, ¹College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujart, India

P-35 Kidney changes after daily slow-bolus IV injection of 10 mL/kg Cremophor EL (R) in 5% dextrose for 2 weeks to Wistar Rats

Kathryn Bowenkamp¹, Karen Killary¹, Danielle Diaz¹, Donna Raab¹, Gregory Argentieri¹, Raviprakash Dugyala¹, ¹Novartis Institutes for BioMedical Resaerch, East Hanover, NJ, United States

P-36 Anti Oxidant Activity Of Dichalcogenide In Rat Liver And Kidney

mohammad Ibrahim¹, J.B.T Rocha¹, ¹Biochemical Toxicology, Santa Maria,RS, Brazil

P-37 Blockade Of Adenosine A1 Receptors With BG9928 Prevents Cisplatin-Induced Acute Renal Injury In Rats

Wendell Davis¹, Eric Whalley¹, Barry Ticho¹, Kathleen Wortham¹, Allan Gill², Don Costab³, ¹Biogen Idec, Cambridge, MA, United States, ²ALS Therapy Development Institute, Cambridge, MA, United States, ³EnVivo Pharma, Watertown, MA, United States

P-38 Nonneoplastic Eye Lesions in Rats and Mice

Margarita Gruebbel¹, Mark Hoenerhoff², ¹Experimental Pathology Laboratories, Research Triangle Park, United States, ²National Institute of Environmental Health Sciences, Research Triangle Park, United States

P-39 Spontaneous Aortitis in the Balb/c Mouse

Rossa Anna Manno¹, Yuval Ramot², Yoshimasa Okazaki³, Vezzali Enrico¹, Michael Krakovsky⁴, Itschak Lamensdorf⁴, Moran Meiron⁵, Amir Toren⁵, Efrat Zehavi-Goldstein⁵, Abraham Nyska⁶, ¹RTC S.p.A., Pomezia, Rome, Italy, ²Hadassah– Hebrew University Medical Center, Jerusalem, Israel, ³Astellas Pharma Inc., Toxicologic Pathology, Drug Safety Research Laboratories, Osaka, Japan, ⁴Pharmaseed Ltd., Ness-Ziona, Israel, ⁵Pluristem Therapeutics Inc., Haifa, Israel, ⁶Sackler School of Medicine, Tel Aviv University, Timrat, Israel

P-40 Doxorubicin Associated Dilated Cardiomyopathy In A German Shepherd Dog

Tiffany Reed^1,2, Joshua Webster^1,2, Stephen Lenz^1,2, Shawna Greene ¹Purdue University Animal Disease Diagnostic Laboratory, West Lafayette, In, United States, ²Purdue University Department of Comparative Pathobiology, West Lafayette, IN, United States, ³Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907

P-41 Mycoplasma Associated Arthritis And Weight Loss In Xenograft Bearing SCID-Beige Mice

Michael Linn¹, Laura Singer¹, Brian Higgins¹, Gary Greenstein¹, Kenneth Kolinsky¹, Wei He¹, Kathryn Packman¹, ¹Hoffmann-La Roche, Nutley, NJ, United States

P-42 Comparison of the Acute Effects of Inhaled Sulfur Mustard and its Surrogate, CEES, in F344 Rats

Thomas March¹, Janet Benson¹, Gary Grotendorst¹, JeanClare Seagrave¹, Waylon Weber¹, ¹Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States

P-43 Ocular Toxicity Caused by Paclitaxel in Neonatal Sprague-Dawley Rats

Maki Kuwata¹, Katsuhiko Yoshizawa¹, Miyo Matsumura¹, Kanji Takahashi¹, Airo Tsubura¹, ¹Kansai Medical University, Moriguchu, Japan

P-44 A Model of Sulfur Mustard Induced Skin Injury in the Hairless Guinea Pig: Time Course of Lesion Development and Drug Efficacy Evaluations

Thomas March¹, Janet Benson¹, JeanClare Seagrave¹, Waylon Weber¹, Gary Grotendorst¹, Gregory Schultz², ¹Lovelace Respiratory Research Institute, Albuquerque, NM, United States, ²College of Medicine, University of Florida, Gainesville, FL, United States

P-45 The Cynodon Dactylon Extract Help Improve Anticholinesterase Effects and Oxidative Stress Caused by Carbofuran in Rat Brain

Bechan Sharma¹, ¹University of Allahabad, Allahabad, UP, India

P-46 Pathobiochemical and Serological Studies on the Effect of Aflatoxin B1 in Chicks with Special Reference to the Lymphoid System

Previn Punnoose¹, Rajendra Lal Sah¹, Jag Mohan Kataria³, Khem Chandra Verma¹, Tripurari Sahay Johri², Shambu Dayal Singh¹, ¹Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India, ²Central Avian Research Institute, Izatnagar, Barreilly, UP, India, ³National Institute of Animal Health, Baghpat, UP, India

P-47 Methotrexate-induced temporal transcriptomic changes in the rat duodenal mucosa

Yi Yang¹, Rita Ciurlionis¹, Wayne Buck¹, Eric Blomme¹, ¹Abbott Laboratories, Abbott Park, IL, United States

P-48 Application of Developmental Neurotoxicology: In-Vivo and Post-Mortem Practical Approaches

Rosa Anna Manno¹, Enrico Vezzali¹, Isabella Andreini¹, Rosaria Cicalese¹, George Krinke², ¹rtc, Research Toxicology Centre, Pomezia Rome, Italy, ²Independent Consultant, Frenkendorf, Switzerland

P-49 A Bilateral Dystrophic Calcinosis Circumscripta in a Cynomolgus Macaque (Macaca fascicularis)

Kenichi Sato¹, Zaher A. Radi², Norbert Makori¹, Dale Morris², James Klaassen¹, Steven Meyer¹, Ryoichi Nagata³, ¹SNBL USA Ltd., Everett, WA, United States, ²Pfizer Global R&D, Chesterfield, MO, United States, ³Shin Nippon Biomedical Laboratories, Ltd., Tokyo, Japan

P-50 Assessment of the Cardiotoxicity of Hydralazine Using an Ultrasensitive Flow-Based Troponin Immunoassay

Igor Mikaelian¹, Denise Coluccio¹, Gerard Hirkaler¹, John C. Downing¹, Erik Rasmussen¹, John Todd², Joel Estis², Quynh Ahn Lu², Rosemary Nicklaus¹, ¹Hoffmann-La Roche, Inc., Nutley, NJ, United States, ²Singulex, Inc., Hayward, CA, United States

P-51 Kainate-induced myocardial necrosis and coronary arteritis were mediated by different pathway

Kiyokazu Ozaki¹, Tetsuro Matsuura¹, Isao Narama¹, ¹Setsunan University, Hirakata/Osaka, Japan

P-52 Summary of Laryngeal Lesions in Fischer 344 Rats and B6C3F1 Mice in National Toxicology Program (NTP) Chronic Inhalation Studies

Glen Marrs¹, Rodney Miller¹, Ronald Herbert², ¹Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, United States, ²National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States

P-53 Temporal Changes in Bone Marrow, Thymus and Lymph Nodes in Rhesus Macaques Following Total Body Ionizing Radiation Exposure

Srinivasa Mantena¹, Bartholomew Amelia², Lublimov Alexander², Lindeblad Matthew², Walling Brent¹, Haschek Wanda¹, ¹University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, United States, ²University of Illinois at Chicago, Chicago,IL, United States

P-54 Focal myocardial degeneration induced by phenylhydrazine in the rats

Hiroshi Edamoto¹, Chiharu Komiya¹, Masahiro Mochizuki¹, Etsuko Ideno¹, Daichi Nakamura¹, Yuko Ichikawa¹, Yoshito Nishihara¹, Kazutoshi Tamura¹, ¹Bozo Research Center Inc., Gotemba, Japan

P-55 Background cardiomyopathy in cynomolgus monkeys (Macaca fascicularis)

Tanja S. Zabka¹, Mudher Albassam¹, ¹Roche, Nutley NJ, United States

P-56 Background Inflammatory Changes within the Stomach of Cynomolgus Monkeys (Macaca fascicularis): Influence of Geographical Origin and Age

Nicholas Macri¹, Creasy Dianne¹, ¹Huntingdon Life Sciences, East Millstone, New Jersey, United States

P-57 Cadmium induces maladaptive cardiac hypertrophy in pregnancy

Kathleen Gabrielson¹, Djahida Bedja¹, Polina Sysa¹, Xin Guo¹, Yi Xu¹, ¹The Johns Hopkins University, Baltimore, MD, United States

P-58 Quantifying Huntingtin Protein Aggregates in a Transgenic Mouse Model of Huntington’s Disease

Kevin Liang¹, Trevor Johnson¹, ¹Aperio, Vista, CA, United States

P-59 Cynomolgus Monkey Retina: characterisation of cell types by immunohistochemistry

Alessandro Piaia¹, Alberta Argentino Storino¹, Patrizia Cristofori¹, ¹GlaxoSmithKline, Verona, Italy

P-60 A Treated Urban Sewage Sludge Sample - In Vivo Toxicity and Genotoxicity Evaluations

Marize de Lourdes Marzo Solano¹, João Francisco Lozano Luvizutto¹, Paula Regina Pereira Silva¹, Patrícia Lepage Alves de Lima¹, Daniele Passarelli¹, Gisela de Aragão Umbuzeiro², João Lauro Viana de Camargo¹, ¹Botucatu Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil, ²Environmental Toxicology, Genotoxicity and Microbiology Division - CETESB, São Paulo, São Paulo, Brazil

P-61 13-Week Repeated Dose Toxicity and Genotoxicity Studies of Cimicifuga heracleifolia Extract

Jeong-Hwan Che¹, Ji-Ran You¹, Yun-Soon Kim¹, Seung-Hyun Kim¹, Ja-June Jang², Hee-Chan Kim¹, Byeong-Cheol Kang^1,2, ¹Clinical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ²Seoul National University College of Medicine, Seoul, Korea, Republic of

P-62 Ozone Exacerbates Acetaminophen-Induced Lung and Liver Toxicity in Mice

Daher Ibrahim Aibo¹, Neil Birmingham¹, Jane Maddox¹, Robert Roth¹, Patricia Ganey¹, James Wagner¹, Jack Harkema¹, ¹Michigan State University, East Lansing, Michigan, United States

P-63 Phospholipidosis Timecourse in HepG2 Cells Treated with Amiodarone: Transmission Electron Microscopic and Gene Expression Analysis

Shannon Burroughs^1,2, Mary Keener¹, Connie Cummings¹, Lawrence Yoon¹, Richard Peterson¹, ¹GlaxoSmithKline, Safety Assessment, Research Triangle Park, NC, United States, ²North Carolina State University, College of Veterinary Medicine, Raleigh, NC, United States

P-64 Immunosuppressive Effects of Pteridium aquilinum In Mice Are Reversed by Selenium Supplementation

Andreia Oliveira Latorre¹, Beatriz Dorr Caniceiro¹, Heidge Fukumasu¹, Silvana Lima Górniak¹, ¹University of São Paulo, São Paulo, SP, Brazil

P-65 Effects of diphenyl diselenide and ebselen on acidosis and iron-induced lipid peroxidation in rat kidney homogenates

Waseem Hassan¹, Joao B T Rocha¹, ¹Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil, Santa Maria -RS, Brazil

P-66 Process Validation of Tissue Cross Reactivity Studies Using CD209 in Cynomolgus

Mylène Valin¹, Thomas Lemarchand¹, Bernard Palate¹, Alexandre Fifre², Roy Forster¹, ¹CIT, Evreux, France, ²Inserm Paris XII Univ., Paris, France

P-67 Reproductive Toxicity In Male Rats By A Mixture Of Pesticides At “Low” Doses

Juliana Elaine Perobelli¹, Meire França Martinez¹, Carla Adriene Franchi¹, João Lauro Viana de Camargo¹, Wilma Kempinas¹, ¹São Paulo State University (UNESP), Department of Pathology, TOXICAM, Botucatu, SP, Brazil

P-68 Characterization of Intestinal Ulceration, Impaired Spermiogenesis and Splenomegaly in the Delta-6 Desaturase (D6D) Null Mouse due to Loss of Highly-Unsaturated Fatty Acids

Sandeep Akare¹, Manabu Nakamura^2,3, Manuel Roqueta-Rivera³, Chad Stroud², Shir Gilor¹, Mariangela Segre¹, Rex Hess⁴, Wanda Haschek¹, ¹Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States, ²Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States, ³Department of Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States, ⁴Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

P-70 Quantitative Imaging Cytometry of Tissue Micro Arrays to Support Preclinical Drug Development

David Krull¹, Richard Peterson¹, ¹GlaxoSmithKline, RTP, NC, United States

P-71 Estimation of Intra-abdominal Adipose Tissue Volume in Mice Using Single Image Computerized Tomography

Brent Walling^1,4, Luhua Zhang², Aleksandra Michalowski¹, Dan Schimel³, Jeeva Munasinghe³, R. Mark Simpson¹, ¹Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, ²Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, ³Nuclear Magnetic Resonance Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States, ⁴Department of Pathobiology, University of Illinois, Urbana, IL, United States

P-72 Radiation Toxins And Mechanisms Of Radiation Toxicity In Development Of Radiation Sickness At High Dose, Dose-Rate, Low And High Linear Energy Transfer Radiation

Vecheslav Maliev¹, Dmitrij Popov^1,2, Ludmila Malieva¹, Viktor Zlobin^1,4, ¹Russian Academy of Science, Vladicaucas, Russian Federation, ²Advanced Medical Technology and Systems Inc., Toronto, Canada, ³Russian Academy of Science, Vladicaucas, Russian Federation, ⁴Russian Academy of Informatics, Sankt-Petersburg, Russian Federation