Do Early-Life Social,Behavioral,and Health Exposures Increase Later-Life Arthritis Incidence?

Abstract

Objectives: This study investigates direct and indirect influences of childhood social, behavioral, and health exposures on later-life osteoarthritis and rheumatoid arthritis development. Methods: Drawing from cumulative inequality theory and six waves of the Health and Retirement Study (2004–2014), we estimate structural equation modeling-based discrete-time survival analysis of the association between six childhood exposure domains and both osteoarthritis and rheumatoid arthritis incidence for men (n = 2720) and women (n = 2974). Using the delta method to test for mediation, we examine indirect effects via selected health-related risks and resources. Results: Risky adolescent behavior is associated with rheumatoid arthritis incidence for women (h.O.R. = 1.883, 95% C.I. [1.016, 3.490]), whereas several types of childhood exposures are associated with later-life osteoarthritis development for both men and women. Experiencing two or more childhood socioeconomic disadvantages is indirectly associated with osteoarthritis (men: coef. = 0.024, 95% C.I. [0.003, 0.045]; women: coef. = 0.111, 95% C.I. [0.071, 0.150]) and rheumatoid arthritis (men: coef. = 0.037, 95% C.I. [0.000, 0.074]; women: coef. = 0.097, 95% C.I. [0.035, 0.159]) development through adult body mass index. Discussion: Findings highlight the importance of childhood contexts in understanding the development of later-life osteoarthritis and rheumatoid arthritis.

Keywords

adverse childhood experiences osteoarthritis rheumatoid arthritis body mass index cumulative inequality theory

Get full access to this article

View all access options for this article.

References

Alpízar-Rodríguez

Finckh

(2017). Environmental factors and hormones in the development of rheumatoid arthritis. Seminars in Immunopathology, 39(4), 461-468. https://doi.org/10.1007/s00281-017-0624-2.

Badley

E. M.

Shields

O’Donnell

Hovdestad

W. E.

Tonmyr

(2019). Childhood maltreatment as a risk factor for arthritis: Findings from a population‐based survey of Canadian adults. Arthritis Care & Research, 71(10), 1366-1371. https://doi.org/10.1002/acr.23776.

Barbour

K. E.

Helmick

C. G.

Boring

Brady

T. J.

(2017). Vital signs: Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2013-2015. MMWR. Morbidity and Mortality Weekly Report, 66, 246-253.

Bayram

Erol

(2014). Childhood traumatic experiences, anxiety, and depression levels in fibromyalgia and rheumatoid arthritis. Noro Psikiyatri Arsivi, 51(4), 344-349. https://doi.org/10.5152/npa.2014.6958.

Blackwell

D. L.

Hayward

M. D.

Crimmins

E. M.

(2001). Does childhood health affect chronic morbidity in later life? Social Science & Medicine, 52, 1269-1284. https://doi.org/10.1016/S0277-9536(00)00230-6.

Bradley

R. H.

Corwyn

R. F.

(2002). Socioeconomic status and child development. Annual Review of Psychology, 53(1), 371-399. https://doi.org/10.1146/annurev.psych.53.100901.135233.

Brennan-Olsen

S. L.

Taillieu

T. L.

Turner

Bolton

Quirk

S. E.

Gomez

Duckham

R. L.

Hosking

S. M.

Duque

Green

Afifi

T. O.

(2018). Arthritis in adults, socioeconomic factors, and the moderating role of childhood maltreatment: Cross-sectional data from the national epidemiological survey on alcohol and related conditions. Osteoporosis International, 30(2), 363-373. https://doi.org/10.1007/s00198-018-4671-x.

Butts

Sternberg

(2004). Different approaches to understanding autoimmune rheumatic diseases: The neuroimmunoendocrine system. Best Practice & Research Clinical Rheumatology, 18(2), 125-139. https://doi.org/10.1016/j.berh.2004.02.002.

Canetti

E. F. D.

Schram

Orr

R. M.

Knapik

Pope

(2020). Risk factors for development of lower limb osteoarthritis in physically demanding occupations: A systematic review and meta-analysis. Applied Ergonomics, 86, 103097. https://doi.org/10.1016/j.apergo.2020.103097.

10.

Centers for Disease Control and Prevention (CDC) (2009). Arthritis as a potential barrier to physical activity among adults with heart disease--United States, 2005 and 2007. MMWR. Morbidity and Mortality Weekly Report, 58(7), 165-169.

11.

Dawson

(2011). Defining risk drinking. Alcohol research & health: the journal of the National Institute on Alcohol Abuse and Alcoholism, 34(2), 144-156.

12.

Elder

G. H.

Jr. (1998). The life course as developmental theory. Child Development, 69(1), 1-12. https://doi.org/10.1111/j.1467-8624.1998.tb06128.x.

13.

Fairchild

A. J.

Abara

W. E.

Gottschall

A. C.

Tein

J.-Y.

Prinz

R. J.

(2015). Improving our ability to evaluate underlying mechanisms of behavioral onset and other event occurrence outcomes. Evaluation & the Health Professions, 38(3), 315-342. https://doi.org/10.1177/0163278713512124.

14.

Felitti

V. J.

Anda

R. F.

Nordenberg

Williamson

D. F.

Spitz

A. M.

Edwards

Koss

M. P.

Marks

J. S.

(1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. American Journal of Preventive Medicine, 14(4), 245-258. https://doi.org/10.1016/S0749-3797(98)00017-8.

15.

Felson

D. T.

Lawrence

R. C.

Dieppe

P. A.

Hirsch

Helmick

C. G.

Jordan

J. M.

Sowers

(2000). Osteoarthritis: New insights. Part 1: The disease and its risk factors. Annals of Internal Medicine, 133(8), 635-646. https://doi.org/10.7326/0003-4819-133-8-200010170-00016.

16.

Ferraro

K. F.

Morton

P. M.

(2018). What do we mean by accumulation? Advancing conceptual precision for a core idea in Gerontology: Table 1. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 73(2), gbv094-278. https://doi.org/10.1093/geronb/gbv094.

17.

Ferraro

K. F.

Schafer

M. H.

Wilkinson

L. R.

(2016). Childhood disadvantage and health problems in middle and later life. American Sociological Review, 81(1), 107-133. https://doi.org/10.1177/0003122415619617.

18.

Ferraro

K. F.

Shippee

T. P.

(2009). Aging and cumulative inequality: How does inequality get under the skin? The Gerontologist, 49(3), 333-343. https://doi.org/10.1093/geront/gnp034.

19.

Festa

D’Agostino

Jr. Williams

Karter

Mayer-Davis

Tracy

Haffner

(2001). The relation of body fat mass and distribution to markers of chronic inflammation. International Journal of Obesity, 25, 1407-1415. https://doi.org/10.1038/sj.ijo.0801792.

20.

Fuller-Thomson

Stefanyk

Brennenstuhl

(2009). The robust association between childhood physical abuse and osteoarthritis in adulthood: Findings from a representative community sample. Arthritis & Rheumatism, 61(11), 1554-1562. https://doi.org/10.1002/art.24871.

21.

Glyn-Jones

Palmer

A. J. R.

Agricola

Price

A. J.

Vincent

T. L.

Weinans

Carr

A. J..

(2015). Osteoarthritis. Lancet, 386(9991), 376-387. https://doi.org/10.1016/S0140-6736(14)60802-3.

22.

Hardt

Rutter

(2004). Validity of adult retrospective reports of adverse childhood experiences: Review of the evidence. Journal of Child Psychology and Psychiatry, 45(2), 260-273. https://doi.org/10.1111/j.1469-7610.2004.00218.x.

23.

Health and Retirement Study (HRS) (2018). Public use dataset. Produced and distributed by the University of Michigan with funding from the National Institute on Aging (grant number NIA U01AG009740), Ann Arbor, MI.

24.

Hootman

J. M.

Helmick

C. G.

Barbour

K. E.

Theis

K. A.

Boring

M. A.

(2016). Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among US adults, 2015-2040. Arthritis & Rheumatology, 68(7), 1582-1587. https://doi.org/10.1002/art.39692.

25.

Innala

Berglin

Möller

Ljung

Smedby

Södergren

Magnusson

Rantapää-Dahlqvist

Wållberg-Jonsson

(2014). Age at onset determines severity and choice of treatment in early rheumatoid arthritis: A prospective study. Arthritis Research & Therapy, 16(2), R94-R99. https://doi.org/10.1186/ar4540.

26.

Karim

Weisz

Bibi

Rehman

(2015). Validation of the eight-item center for epidemiologic studies depression scale (CES-D) among older adults. Current Psychology, 34(4), 681-692. https://doi.org/10.1007/s12144-014-9281-y.

27.

Kopec

J. A.

Sayre

E. C.

(2004). Traumatic experiences in childhood and the risk of arthritis. Canadian Journal of Public Health, 95, 361-365. https://doi.org/10.1007/BF03405147.

28.

Kuh

Ben-Shlomo

Lynch

Hallqvist

Power

(2003). Life course epidemiology. Journal of Epidemiology and Community Health, 57(10), 778-783.

29.

Lee

Park

Kwon

(2021). Life course pathway to later-year depressive symptoms: Multiple mediation of socio-economic status and coping resources by gender. Research on Aging, 43(5-6), 237-249. https://doi.org/10.1177/0164027520958761.

30.

Link

B. G.

Phelan

(1995). Social conditions as fundamental causes of disease. Journal of Health and Social Behavior, 80-94. https://doi.org/10.2307/2626958.

31.

Masyn

K. E.

(2009). Discrete-time survival factor mixture analysis for low-frequency recurrent event histories. Research in Human Development, 6(2-3), 165-194. https://doi.org/10.1080/15427600902911270.

32.

Miller

G. E.

Chen

Parker

K. J.

(2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137(6), 959-997. https://doi.org/10.1037/a0024768.

33.

Morton

P. M.

Ferraro

K. F.

(2020). Early social origins of biological risks for men and women in later Life. Journal of Health and Social Behavior, 61(4), 503-522. https://doi.org/10.1177/0022146520966364.

34.

Morton

P. M.

Schafer

M. H.

Ferraro

K. F.

(2012). Does childhood misfortune increase cancer risk in adulthood? Journal of Aging and Health, 24(6), 948-984. https://doi.org/10.1177/0898264312449184.

35.

Murphy

L. B.

Cisternas

M. G.

Pasta

D. J.

Helmick

C. G.

Yelin

E. H.

(2017). Medical expenditures and earnings losses among US adults with arthritis in 2013. Arthritis Care & Research, 70(6), 869-876. https://doi.org/10.1002/acr.23425.

36.

Muthén

(2011). Applications of causally defined direct and indirect effects in mediation analysis using SEM in Mplus. (pp. 1-110).

37.

Muthén

Masyn

(2005). Discrete-time survival mixture analysis. Journal of Educational and Behavioral Statistics, 30(1), 27-58. https://doi.org/10.3102/10769986030001027.

38.

Patrick

Nicklas

T. A.

(2005). A review of family and social determinants of children’s eating patterns and diet quality. Journal of the American College of Nutrition, 24(2), 83-92. https://doi.org/10.1080/07315724.2005.10719448.

39.

Peek

M. K.

Coward

R. T.

(2000). Antecedents of disability for older adults with multiple chronic health conditions. Research on Aging, 22(4), 422-444. https://doi.org/10.1177/0164027500224005.

40.

Pratschke

Haase

Comber

Sharp

de Camargo Cancela

Johnson

(2016). Mechanisms and mediation in survival analysis: Towards an integrated analytical framework. BMC Medical Research Methodology, 16(1), 1-13. https://doi.org/10.1186/s12874-016-0130-6.

41.

Raykov

Gorelick

P. B.

Zajacova

Marcoulides

G. A.

(2017). On the potential of discrete time survival analysis using latent variable modeling: An application to the study of the vascular depression hypothesis. Structural Equation Modeling: A Multidisciplinary Journal, 24(6), 926-935. https://doi.org/10.1080/10705511.2017.1315305.

42.

Read

J. N. G.

Gorman

B. K.

(2010). Gender and health inequality. Annual Review of Sociology, 36, 371-386. https://doi.org/10.1146/annurev.soc.012809.102535.

43.

Schlomer

G. L.

Bauman

Card

N. A.

(2010). Best practices for missing data management in counseling psychology. Journal of Counseling Psychology, 57, 1-10. https://doi.org/10.1037/a0018082.

44.

Schwetlik

S. N.

Baldock

K. L.

Hill

C. L.

Ferrar

(2021). Chronic stress and arthritis: A scoping review. Arthritis Care & Research. Accepted Author Manuscript https://doi.org/10.1002/acr.24528.

45.

Scott

K. M.

Von Korff

Angermeyer

M. C.

Benjet

Bruffaerts

De Girolamo

Maria Haro

Lepine

J.-P.

Ormel

Posada-Villa

Tachimori

Kessler

R. C.

(2011). Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Archives of General Psychiatry, 68(8), 838-844. https://doi.org/10.1001/archgenpsychiatry.2011.77.

46.

Smith

N. R.

Ferraro

K. F.

Kemp

B. R.

Morton

P. M.

Mustillo

S. A.

Angel

J. L.

(2019). Childhood misfortune and handgrip strength among black, white, and hispanic Americans. The Journals of Gerontology: Series B, 74(3), 526-535. https://doi.org/10.1093/geronb/gbw147.

47.

Spitzer

Wegert

Wollenhaupt

Wingenfeld

Barnow

Grabe

H. J.

(2013). Gender-specific association between childhood trauma and rheumatoid arthritis: A case-control study. Journal of Psychosomatic Research, 74(4), 296-300. https://doi.org/10.1016/j.jpsychores.2012.10.007.

48.

Springer

K. W.

Sheridan

Kuo

Carnes

(2007). Long-term physical and mental health consequences of childhood physical abuse: Results from a large population-based sample of men and women. Child Abuse & Neglect, 31, 517-530. https://doi.org/10.1016/j.chiabu.2007.01.003.

49.

Tukey

J. W.

(1977). Exploratory data analysis. Addison-Wesley.

50.

Vazquez

C. E.

Cubbin

(2020). Socioeconomic status and childhood obesity: A review of literature from the past decade to inform intervention research. Current Obesity Reports, 9, 562-570. https://doi.org/10.1007/s13679-020-00400-2.

51.

Vigdorchik

J. M.

Nepple

J. J.

Eftekhary

Leunig

Clohisy

J. C.

(2017). What is the association of elite sporting activities with the development of hip osteoarthritis? The American Journal of Sports Medicine, 45(4), 961-964. https://doi.org/10.1177/0363546516656359.

52.

Von Korff

Alonso

Ormel

Angermeyer

Bruffaerts

Fleiz

de Girolamo

Kessler

R. C.

Kovess-Masfety

Posada-Villa

Scott

K. M.

Uda

(2009). Childhood psychosocial stressors and adult onset arthritis: Broad spectrum risk factors and allostatic load. Pain, 143(1), 76-83. https://doi.org/10.1016/j.pain.2009.01.034.

53.

Vuolo

Ferraro

K. F.

Morton

P. M.

Yang

T.-Y.

(2014). Why do older people change their ratings of childhood health? Demography, 51(6), 1999-2023. https://doi.org/10.1007/s13524-014-0344-3.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.49 MB