This monograph presents a tutorial review of the current state-of-the-art in ultrasonic attenuation estimation in reflection. Clinical indications which provide the motivation for attempting in vivo attenuation estimation are discussed. Frequency and time domain techniques and their respective tradeoffs and problems are presented. Finally, current clinical results obtained with the various techniques are summarized and further areas of study are suggested.
WellsP. N. T., Biomedical Ultrasonics, (Academic Press, London, 1977).
2.
PaulyH.SchwanH. P., Mechanism of absorption of ultrasound in liver tissue, J. Acoust. Soc. Am.50, 692–699, (1971).
3.
NayaranaP. A.OphirJ., A closed form method for the measurement of attenuation in nonlinearly dispersive media, Ultrasonic Imaging5, 17–21 (1983).
4.
StepanishenP. R., Wide Bandwidth Acoustic Near and Far Field Transients from Baffled Pistons, in 1977 IEEE Ultrasonics Symposium Proceedings, pp. 113–118 (IEEE Cat. No. 77CH264).
5.
RobinsonD. E.WilsonL. S.BianchiT., In vivo characterization of beams for ultrasonic attenuation measurements, Ultrasonic Imaging6, 217 (1984) (Abstract only).
6.
SommerF. G.FillyR. A.MintonM.D., Acoustic shadowing due to refractive and reflective effects, Amer. J. Roentgenol.132, 973–977 (1979).
7.
RobinsonD. E.WilsonL. S.KossoffG., Shadowing and enhancement in ultrasonic echograms by reflection and refraction, J. Clin. Ultrasound9, 181–188 (1981).
8.
RichmanT. S., Taylor, K. J. W. and Kremkau, F. W., Propagation speed artifact in a fatty tumor (myelolipoma): significance for tissue differential diagnosis, J. Ultrasound Med.2, 45–47 (1983).
9.
FillyR. A.SommerF. G.MintonM. J., Characterization of biological fluids by ultrasound and computed tomography, Radiology134, 167–171 (1980).
10.
JaffeC. C.RosenfieldA. T.SommerG.TaylorK. J. W., Technical factors influencing the imaging of small anechoic cysts by B-scan ultrasound, Radiology135, 429–433 (1980).
11.
FreimanisA. K.AsherW. M., Development of diagnostic criteria in echographic study of abdominal lesions. Amer. J. Roentgenol.108, 747–755 (1970).
12.
CallenP. W.MarksW. M., Lymphomatous masses simulating cysts by ultrasonography, J. Can. Assoc. Radiol.30, 244–246 (1979).
13.
ChinnD. H.FillyR. A.CallenP. W., Unusual ultrasonographic appearance of a solid schwannoma, J. Clin. Ultrasound10. 243–245 (1982).
14.
SheuJ. C.SungJ. L.ChenD. S.YuJ. Y.WangT. H.SuC. T.TsanyY. M., Ultrasonography of small hepatic tumors using high-resolution linear-array real-time instruments, Radiology150, 797–802 (1984).
15.
TabouryJ.PorcelA.TubianaJ. M.MonnierJ. P., Cavernous hemangiomas of the liver studied by ultrasound, Radiology149, 781–785 (1983).
16.
WootenW. B.GreenB.GoldsteinH. M., Ultrasonography of necrotic hepatic metastases, Radiology128, 447–450 (1978).
17.
SommerF. G.TaylorK. J. W., Differentiation of acoustic shadowing due to calculi and gas collections, Radiology135, 399–403 (1980).
18.
GosinkB. B.LemonS. K.ScheibleW.LeopoldG. R., Accuracy of ultrasonography in diagnosis of hepatocellular disease, Am. J. Roentgenol.133, 19–23 (1979).
19.
DewberryK. C.ClarkB., The accuracy of ultrasound in the detection of cirrhosis of the liver, Brit. J. Radiology52, 945–948 (1979).
20.
DunnF., Ultrasonic Attenuation, Absorption, and Velocity in Tissues and Organs, in Ultrasonic Tissue Characterization, LinzerM., ed. National Bureau of Standards Spec. Publ. 453, pp. 21–28 (U.S. Government Printing Office, Washington, D. C., 1976).
21.
O'DonnellM.MimbsJ. W.MillerJ. G., The relationship between collagen and ultrasonic attenuation in myocardial tissue, J. Acoust. Soc. Amer.65, 512–517 (1979).
22.
GossS. A.JohnstonR. L.DunnF., Comprehensive compilation of empirical ultrasonic properties of mammalian tissues, J. Acoust. Soc. Amer.64, 423–457 (1978).
23.
JohnstonR. L.GossS. A.MaynardV.BradyJ. K.FrizzellL. A.O'BrienW. D.Jr.DunnF., Elements of Tissue Characterization. Part I: Ultrasonic Propagation Properties, in Ultrasonic Tissue Characterization II, LinzerM., ed., NBS Spec. Publ. 525, pp. 19–27 (U. S. Government Printing Office, Washington, DC, 1979).
24.
ScatarigeJ. D.ScottW. W.DonovanP. J.SigelmanS. S.SandersR. C., Fatty infiltration of the liver: ultrasonographic and computed tomographic correlation, J. Ultrasound Med.3, 9–14 (1984).
25.
BamberJ. C.HillC. R.KingJ. A., Acoustic properties of normal and cancerous human liver - II. Dependence of tissue structure, Ultrasound Med. Biol.7, 135–144 (1981).
26.
TaylorK. J. W.GorelickF. S.RosenfieldA. T.RileyC. A., Ultrasonography of alcoholic liver disease with histological correlation, Radiology141, 157–161 (1981).
27.
KucR., Clinical application of an ultrasound attenuation coefficient estimation technique for liver pathology characterization, IEEE Trans. Biomed. Eng.BME-27, 312–319 (1980).
28.
OphirJ.MakladN.F.BigelowR. H., Ultrasonic attenuation measurements of in vivo human muscle, Ultrasonic Imaging4, 290–295 (1982).
29.
FinkM.HottierF.CardosoJ. F., Ultrasonic signal processing for in vivo attenuation measurement; short time Fourier analysis, Ultrasonic Imaging5, 117–135 (1983).
30.
MakladN. F.OphirJ.BalsaraV., Attenuation of ultrasound in normal liver and diffuse diseases in vivo, Ultrasonic Imaging6, 117–125 (1984).
31.
OphirJ.MakladN.F., Precision Ultrasound Attenuation Measurement. US Patent #4,389,893 (1983).
32.
SommerF. G.JoyntL. F.CarrollB. A.MacovskiA., Ultrasonic characterization of abdominal tissues via digital analysis of backscattered waveforms, Radiology141, 811–817 (1981).
33.
NovickG., (Personal communication) (1983).
34.
LizziF., (Personal communication) (1983).
35.
MakladN. F., Unpublished data. (1984).
36.
BensonD. M.WaldroupL. D.KurtzA. B.RoseJ. D.RifkinM. D.GoldbergB. B., Ultrasonic tissue characterization of fetal lung, liver and placenta for the purpose of assessing fetal maturity, J. Ultrasound Med.6, 489–494 (1983).
37.
MeltonH. E.Jr.SkortonD. J., Rational-gain-compensation for attenuation in ultrasonic cardiac imaging, in 1981 IEEE Ultrasonics Symposium Proceedings, pp. 607–611 (IEEE Cat. No. 81 CH 1689-9).
38.
CohenR. D.MottleyJ. G.MillerJ. G.KurnikP. B.SobelB. E., Detection of ischemic myocardium in vivo through the chest wall by quantitative ultrasonic tissue characterization, Am. J. Cardiology50, 838–843 (1982).
KucR., Statistical Estimation of the Acoustical Attenuation Slope for Liver Tissue, Ph.D. Thesis (Columbia University Press, New York, 1977).
41.
LizziF. L.LaviolaM. A., Power Spectra Measurements of Ultrasonic Backscatter from Ocular Tissues, in 1975 IEEE Ultrasonics Symposium Proceedings, pp. 29–31 (IEEE Cat. No. 75 CH 0994-4SU).
42.
LizziF. L.KatzL.St. LouisL.ColemanD. J., Applications of spectral analysis in medical ultrasonography, Ultrasonics14, 77–80 (1976).
43.
LizziF. L.ElbaumM. E., Clinical Spectrum Analysis Techniques for Tissue Characterization, in Ultrasonic Tissue Characterization II, LinzerM., ed., NBS Spec. Publ. 525, pp. 111 (U.S. Government Printing Office, Washington, DC, 1979).
44.
LizziF. L.FeleppaE.JaremkoN.KingD. L.WeiP., Computer Analysis System for Ultrasonic Backscatter from Liver and Kidney, 1980 Ultrasonics Symposium Proceedings, pp. 1059–1062 (IEEE Cat. No. 80CH 1602-2).
45.
LeleP. P.NameryJ., A Computer-based Ultrasonic System for the Detection and Mapping of Myocardial Infarcts, in 1974 San Diego Biomed. Symposium Proceedings13, IEEE Pub., p. 121.
46.
NameryJ.LeleP. P., Ultrasonic Detection of Myocardial Infarction in the Dog, in 1972 IEEE Ultrasonics Symposium Proceedings, pp. 491–494 (IEEE Cat. No. 72CH 0708-8SU).
47.
JonesJ. P.BehrensM., In vivo measurement of frequency-dependent attenuation in normal liver, pancreas and spleen, Ultrasonic Imaging3, 205 (1981) (Abstract only).
48.
DuckF. A.HillC. R., Acoustic Attenuation Reconstruction from Back-scattered Ultrasound, in Proc. IFIP TC-4 Working Conference on Computer Aided Tomography and Ultrasonics in Medicine, pp. 137–148 (North Holland Publ. Co., New York, 1979).
KucR.SchwartzM.VonMicskyL., Parametric Estimation of the Acoustic Attenuation Coefficient Slope for Soft Tissue, in 1976 IEEE Ultrasonics Symposium Proceedings, pp. 44–47 (IEEE Cat. No. 76CH 1120-5SU).
59.
KucR.SchwartzM.FinbyN.DainF., Statistical Estimation of the Acoustic Attenuation Coefficient Slope for Liver Tissue from Reflected Ultrasonic Signals, in Ultrasonic Tissue Characterization II, LinzerM., ed., NBS Spec. Publ. 525, p. 125 (U. S. Government Printing Office, Washington, DC, 1979).
60.
LizziF. L.LaviolaM. A., Tissue Signature Characterization Utilizing Frequency Domain Analysis, in 1976 IEEE Ultrasonics Symposium Proceedings, pp. 714–719 (IEEE Cat. No. 76CH 1120-5SU).
61.
NarayanaP. A.OphirJ., On the frequency dependence of attenuation in normal and fatty liver, IEEE Trans. Sonics UltrasonicsSU-30, 379–383 (1983).
62.
NarayanaP. A.OphirJ., On the validity of the linear approximation in the parametric measurement of attenuation in tissues, Ultrasound Med. Biol.9. 357–361 (1983).
63.
MillerJ. G.YuhasD. E.MimbsJ. W.DierkerS. B.BusseL. J.LaterraJ. J.WeissA. N.SobelB. E., Ultrasonic Tissue Characterization: Correlation between Biochemical and Ultrasonic Indices and Myocardial Injury, in 1976 IEEE Ultrasonics Symposium Proceedings, pp. 33–43 (IEEE Cat. No. 76CH 1120-5SU).
64.
LeleP. P.MansfieldA. B.MurphyA. I.NameryJ.SenapatiN., Tissue Characterization by Ultrasonic Frequency-dependent Attenuation and Scattering, in Ultrasonic Tissue Characterization, LinzerM., ed. National Bureau of Standards Spec. Publi. 453, pp. 167–196 (U. S. Government Printing Office, Washington, D. C., 1975).
65.
KucR.SchwartzM.FinbyN.DainF., Variance Reduction in the Characterization of Liver Tissue Using Reflected Ultrasonic Signals, in 1977 IEEE Ultrasonics Symposium Proceedings, pp. 219–222 (IEEE Cat. No. 77CH 1264-1SU).
66.
KucR. B.SchwartzM., Estimating the acoustic attenuation slope for liver from reflected ultrasound signals, IEEE Trans. Sonics UltrasonicsSU-26, 353–362 (1979).
67.
KucR.TaylorK. J. W., Variation of acoustic attenuation coefficient slope estimates for in vivo liver, Ultrasound Med. Biol.8, 403–412 (1982).
68.
JohnstonP. H.ThomasL. J.IIILewisJ. T.MillerJ. G., A comparison of methods for estimating attenuation using backscattered ultrasound, Ultrasonic Imaging4, (1982) (Abstract only).
69.
RobinsonD. E., Computer Spectral Analysis of Ultrasonic A-mode Signals, in Ultrasonic Tissue Characterization II, LinzerM., ed., NBS Spec. Publ. 525, p. 281 (U. S. Government Printing Office, Washington, DC, 1979).
70.
FraserJ.KinoG. S.BirnholzJ., Cepstral Signal Processing for Tissue Signature Analysis, in Ultrasonic Tissue Characterization II, LinzerM., ed., NBS Spec. Publ. 525, p. 287 (U. S. Government Printing Office, Washington, DC, 1979).
71.
MerkulovaV. M., Accuracy of the pulse method for measuring the attenuation and velocity of ultrasound, Soviet Physics — Acoustics12, 411–414 (1967).
72.
SerabianS., Influence of attenuation upon the frequency content of a stress wave packet in graphite, J. Acoust. Soc. Amer.42, 1052–1059 (1967).
73.
NarayanaP. A.OphirJ., Spectral shifts of ultrasonic propagation: A study of theoretical and experimental models, Ultrasonic Imaging5, 22–29 (1983).
74.
OphirJ.JaegerP., Spectral shifts of ultrasonic propagation through media with nonlinear dispersive attenuation, Ultrasonic Imaging4, 282 (1982) (Abstract only).
75.
FinkM.HottierF., Short Time Fourier Analysis and Diffraction Effect in Biological Tissue Characterization, Acoustical ImagingVol. 12, pp. 493–503 (Plenum Press1982).
76.
FerrariL.JonesJ.GonzalezV.BehrensM., Acoustical Imaging using the Phase of Echo Waveforms, Acoustical ImagingVol 12, pp. 635–641 (Plenum Press1982).
77.
MeyerC. R., An iterative, parametric spectral estimation technique for high-resolution pulse-echo ultrasound, IEEE Trans. Biomed. Eng.BME-26, 207–212 (1979).
78.
MeyerC. R., Preliminary results on a system for wide-band reflection-mode ultrasonic attenuation imaging, IEEE Trans. Sonics UltrasonicsSU-29, 12–17 (1982).
79.
CloostermansM.J.T.M.ThijssenJ. M., A beam corrected estimation of the frequency dependent attenuation of biological tissues from backscattered ultrasound, Ultrasonic Imaging5, 136–147 (1983).
80.
O'DonnellM., Effects of diffraction on measurements of the frequency-dependent ultrasonic attenuation, IEEE Trans. Biomed. Eng.BME-30, 320–326 (1983).
81.
InsanaM.ZagzebskiJ.MadsenE., Improvements in the spectral difference method for measuring ultrasonic attenuation, Ultrasonic Imaging5, 331–345 (1983).
82.
SimondsR. M., Propagation of broadband ultrasound in attenuating media, Ultrasonic Imaging5, 148–160 (1983).
FlaxS. W.GloverG. H.PelcN. J., Textural variations in B-mode ultrasonography: A stochastic model, Ultrasonic Imaging3, 235–257 (1981).
85.
BusseL. J.MillerJ.G., A Comparison of Finite Aperture Phase Sensitive and Phase Insensitive Detection in the Near Field of Inhomogeneous Material, in 1981 IEEE Ultrasonics Symposium Proceedings, pp. 617–626 (IEEE Cat. No. 81CH 1689-9).
86.
BusseL. J.MillerJ.G., Detection of spatially nonuniform ultrasonic radiation with phase sensitive (piezoelectric) and phase insensitive (acoustoelectric) receivers, J. Acoust. Soc. Amer.70, 1377–1386 (1981).
87.
DinesL. A.KakA. C., Measurement and Reconstruction of Ultrasonic Parameters for Diagnostic Imaging Research Report TR-EE 77-14, School of Electrical Engineering, Purdue University, West Lafayette, Indiana (Dec. 1976).
88.
MountfordR. A.WellsP. N. T., Ultrasonic liver scanning: the quantitative analysis of the normal A-scan, Phys. Med. Biol.17, 14–25 (1972).
89.
MountfordR. A.WellsP. N. T., Ultrasonic liver scanning: the A-scan in the normal and cirrhosis, Phys. Med. Biol.17, 261–269 (1972).
RobinsonD. E.WilsonL. S.BianchiT., In vivo characterization of beams for ultrasonic attenuation measurements, Ultrasonic Imaging6, 217 (1984) (Abstract only).
92.
FerrariL.JonesJ.GonzalezV.BehrensM., In vivo measurement of attenuation based on the theory of Gaussian pulse propagation, Ultrasonic Imaging4, 178 (1982) (Abstract only).
93.
FlaxS. W.PelcN. J.GloverG. H., Spectral characterization and attenuation measurements in ultrasound, Ultrasonic Imaging5, 95–116 (1983).
94.
RiceS. O., Mathematical analysis of random noise, Bell syst. Tech. J.23, 282–332 (1944); 24, 46–108 (1945).
95.
LinzerM.NortonJ. E., Ultrasonic Tissue Characterization, in Ann. Rev. Biophys. Bioeng.Vol. 11, pp. 303–329 (1982).
96.
HillC. R., Ultrasonic Attenuation and Scattering by Tissues, in Handbook of Clinical Ultrasound, de VliegerM., eds., pp. 91–98, (Wiley Publishing Co., New York, 1978).
97.
BamberJ. C.HillC. R., Acoustic properties of normal and cancerous human liver I: dependence on pathological conditions, Ultrasound Med. Biol.7, 121–133 (1981).
98.
GossS. A.FrizzellL. A.DunnF., Ultrasonic absorption and attenuation in mammalian tissues, Ultrasound Med. Biol.5, 181–186 (1979).
99.
NicholasD., Evaluation of backscattering coefficients for excised human tissues: Results, interpretation and associated measurements, Ultrasound Med. Biol.8, 17–28 (1982).
100.
JonesJ. P.BehrensM.FerrariL.GonzalezW., In vivo Differentiation of Abdominal Organs and Early Detection of Cirrhosis of the Liver, in Proc. 26th Ann. Conv. AIUM, p. 68 (1981) (Abstract only).
101.
KucR., Estimating acoustic attenuation from reflected ultrasound signals: comparison of spectral-shift and spectral-difference approaches, IEEE Trans. Acoustics, Speech Sig. Proc.ASSP-32, 1–6 (1984).
102.
PapadakisE. P.FowlerK. A., Broad-band transducers: radiation fields and selected applications, J. Acoust. Soc. Amer.50, 729–745 (1971).
103.
OphirJ., Parametric vs. nonparametric measurements in tissues with nonlinear frequency dependent attenuation, Ultrasound Med. Biol., (1984) (In press).
104.
ShafferA.PettiboneD. W.HavliceJ. F.NassiM., Estimation of the slope of the attenuation coefficient, Ultrasonic Imaging6, 126–138 (1984).
GerzbergL.MeindlJ. D., Power spectrum centroid detection for Doppler systems application, Ultrasonic Imaging2, 232–261 (1980).
111.
NarayanaP. A.OphirJ., The measurement of attenuation in nonlinearly attenuating media by the zero crossing method, Ultrasound Med. Biol. (In press).
112.
ReidJ. M.SikovM. R., (Eds.), Interaction of Ultrasound and Biological Tissues (Proceedings of a workshop held at Battelle Seattle Research Center, November 8–11, 1971), DHEW Publication FDA-73-8008 BRH/DBE 73-1 (September 1972).
113.
HussyM., Diagnostic Ultrasound: An Introduction to the Interactions between Ultrasound and Biological Tissues (John Wiley and Sons, New York, 1975).
114.
GossS. A.JohnstonR. L.DunnF., Compilation of empirical ultrasonic properties of mammalian tissues, II, J. Acoust. Soc. Amer.68, 93–108 (1980).
115.
EriksonK.R.FryF. J.JonesJ. P., Ultrasound in medicine - a review, IEEE Trans. Sonics UltrasonicsSU-21, 144–170 (1974).
116.
LinzerM. (editor), Ultrasonic Tissue Characterization, National Bureau of Standards Spec. Publ. 453 (U. S. Government Printing Office, Washington, D. C., 1976).
117.
WellsP. N. T., Biomedical Ultrasonics (Academic Press, 1977).
118.
WhiteD. N. (editor) Recent Advances in Ultrasound in Biomedicine (Research Studies Press, 1977).
119.
LinzerM. (editor) Ultrasonic Tissue Characterization II, National Bureau of Standards Spec. Publ. 525 (U. S. Government Printing Office, Washington, D. C., 1979).
JonesJ. P.LeemanS., Ultrasonic Tissue Characterization and Quantitative Ultrasound Scatter Imaging: Methods and Approaches, in 1982 Proc. International Workshop on Physics and Engineering in Medical Imaging, pp. 247–258 (IEEE Cat. No. CH1751-7, 1982).
122.
JonesJ. P.LeemanS., Ultrasonic tissue characterization: a review, Acta Electronica26 (1–2), pp. 3–31 (1984).
123.
WildJ. J.ReidJ. M., Further pilot echographic studies on histologic structures of tumors of the living intact human breast, Amer. J. Path.28, 839 (1952).
124.
JonesJ. P.LeemanS.FerrariL.FinkM., Digital processing of pulse-echo signals for the quantitative mapping of acoustical attenuation in vivo, IEEE Trans. Sonics Ultrasonics (In press).
125.
BamberJ. C.FryF.J.HillC. R.DunnF., Ultrasonic attenuation and backscattering by mammalian organs as a function of time after excision, Ultrasound Med. Biol.3, 15–20 (1977).
126.
JonesJ. P.BehrensM.GonzalezV.KovackR., In-vivo estimates of attenuation from pulse-echo waveforms using measurements of the spectral difference at two depths, Ultrasound Med. Biol. (In press).
127.
InsanaM. F.ZagzegskiJ. A.MadsenE. L.FrankG. R., Analysis of a spectral difference method for measuring the slope of attenuation coefficients, Ultrasonic Imaging5, (1983) (Abstract only).
128.
HavliceJ. F.NassiM.RossettiA. J.ShafferS.SommerG., Digitized RF Data Acquisition: Application to Estimating Tissue Attenuation, in Proc. 28th Ann. Convention of AIUM, p. 149 (1983) (Abstract only).
129.
ParkerK. J.WaagR. C., Frequecny dependent attenuation measurements from a clinical imaging system, Ultrasonic Imaging5, 175 (1983) (Abstract only).
130.
ParkerK. J.WaagR. C., Clinical attenuation measurements - some results and implications, Ultrasonic Imaging6, 228 (1984) (Abstract only).
131.
LizziF. L.RorkeM.FeleppaE. J.KingD. L.WaiP., Characterization of liver using families of parameters derived from spectrum analysis, Ultrasonic Imaging5, 188 (1983). (Abstract only).
132.
JonesJ. P.GonzalezV.BehrensM.FerrariL., In vivo differentiation of abdominal organs in thirty normal human subjects by the analysis of A-mode ultrasound waveforms, Ultrasonic Imaging3, 187 (1981) (Abstract only).
133.
LeemanS.HutchinsL.HeckmattJ. Z.JonesJ. P., Characterization of human muscle, J. Ultrasound Med.2, 159 (1983).
134.
MottleyJ. G.GlueckR. M.PerezJ. E.SobelB. E.MillerJ. G., Regional differences in the cyclic variation of myocardial backscatter and modification by ischemia, Ultrasonic Imaging5, 183 (1983) (Abstract only).
135.
LizziF. L.FeleppaE. J.ColemenD. J.SilvermanR.TorpeyJ., Characterization of ophthalmic tumor type and assessment of therapy effectiveness, Ultrasonic Imaging5, 184 (1983) (Abstract only).
136.
ShawkerT. H.ArgerP. H.GarraB. S.KucR.MakladN. F.TaylorK. J. W., Tutorial and panel discussion on clinical attenuation measurements, Ultrasonic Imaging6, 231 (1984) (Abstract only).