There are two well-known ultrasonic approaches to extract sets of quantitative parameters: Lizzi–Feleppa (LF) parameters: slope, intercept, and midband; and quantitative ultrasound (QUS)–derived parameters: effective scatterer diameter (ESD) and effective acoustic concentration (EAC). In this study, the relation between the LF and QUS-derived parameters is studied theoretically and experimentally on ex vivo mouse livers. As expected from the theory, LF slope is correlated to ESD (), and from experimental data, LF midband is correlated to EAC (). However, LF intercept is not correlated to ESD () nor EAC (). The unexpected correlation observed between LF slope and EAC () results likely from the high correlation between ESD and EAC due to the inversion process. For a liver fat percentage estimation, an important potential medical application, the parameters presenting the better correlation are EAC () and LF midband ().
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