Photoacoustic (PA) imaging of interphalangeal peripheral joints is of interest in the context of using the synovial membrane as a surrogate marker of rheumatoid arthritis. Previous work has shown that ultrasound (US) produced by absorption of light at the epidermis reflects on the bone surfaces within the finger. When the reflected signals are backprojected in the region of interest, artifacts are produced, confounding interpretation of the images. In this work, we present an approach where the PA signals known to originate from the epidermis are treated as virtual US transmitters, and a separate reconstruction is performed as in US reflection imaging. This allows us to identify the bone surfaces. Furthermore, the identification of the joint space is important as this provides a landmark to localize a region-of-interest in seeking the inflamed synovial membrane. The ability to delineate bone surfaces allows us to identify not only the artifacts but also the interphalangeal joint space without recourse to new US hardware or a new measurement. We test the approach on phantoms and on a healthy human finger.
AlamanosYDrososAA. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev. 2005;4(3):130-6.
2.
van VollenhovenRF. Treatment of rheumatoid arthritis: state of the art 2009. Nat Rev Rheumatol. 2009;5(10):531-41.
3.
PrevooMLvan’tHofMAKuperHHvan LeeuwenMAvan de PutteLBvan RielPL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38(1):44-8.
4.
SchipperLGvan HulstLTCGrolRvan RielPLCMHulscherMEJLFransenJ. Meta-analysis of tight control strategies in rheumatoid arthritis: protocolized treatment has additional value with respect to the clinical outcome. Rheumatology (Oxford). 2010;49(11):2154-64.
5.
BrownAK. Using ultrasonography to facilitate best practice in diagnosis and management of RA. Nat Rev Rheumatol. 2009;5(12):698-706.
6.
FilippucciESalaffiFCarottiMGrassiW. Doppler ultrasound imaging techniques for assessment of synovial inflammation. Rep Med Imaging. 2013;6:83-91.
7.
ChamberlandDJiangYWangX. Optical imaging: new tools for arthritis. Integr Biol (Camb). 2010;2(10):496-509.
8.
HitchonCAEl-GabalawyHS. The synovium in rheumatoid arthritis. Open Rheumatol J. 2011;5:107-14.
9.
FukaeJTanimuraKAtsumiTKoikeT. Sonographic synovial vascularity of synovitis in rheumatoid arthritis. Rheumatology (Oxford). 2013;53(4):586-91.
10.
VasanthLCFooLFPotterHGAdlerRSFinzelKCPavlovH. Using magnetic resonance angiography to measure abnormal synovial blood vessels in early inflammatory arthritis: a new imaging biomarker?J Rheumatol. 2010;37(6):1129-35.
11.
MacéEMontaldoGCohenIBaulacMFinkMTanterM. Functional ultrasound imaging of the brain. Nat Methods. 2011;8(8):662-4.
12.
XuGRajianJRGirishGKaplanMJFowlkesJBCarsonPL. Photoacoustic and ultrasound dual-modality imaging of human peripheral joints. J Biomed Opt. 2013;18(1):10502.
13.
LutzweilerCMeierRRummenyENtziachristosVRazanskyD. Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature. Opt Lett. 2014;39(14):4061-4.
14.
van EsPBiswasSKMoensHJBSteenbergenWManoharS. Initial results of finger imaging using photoacoustic computed tomography. J Biomed Opt. 2014;19(6):060501.
15.
JoseJWilleminkRGHSteenbergenWSlumpCHvan LeeuwenTGManoharS. Speed-of-sound compensated photoacoustic tomography for accurate imaging. Med Phys. 2012;39(12):7262-71.
16.
HeijblomMPirasDXiaWVan HespenJCGKlaaseJMVan Den EnghFM. Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements?Opt Express. 2012;20(11):11582-97.
17.
KitaiTToriiMSugieTKanaoSMikamiYShiinaT. Photoacoustic mammography: initial clinical results. Breast Cancer. 2014;21(2):146-53.
18.
KrugerRAKuzmiakCMLamRBReineckeDRDel RioSPSteedD. Dedicated 3D photoacoustic breast imaging. Med Phys. 2013;40(11):113301.
19.
ErmilovSAKhamapiradTConjusteauALeonardMHLacewellRMehtaK. Laser optoacoustic imaging system for detection of breast cancer. J Biomed Opt. 2009;14(2):024007.
20.
ZhouYXingWMaslovKICorneliusLAWangLV. Handheld photoacoustic microscopy to detect melanoma depth in vivo. Opt Lett. 2014;39(16):4731-4.
21.
LauferJJohnsonPZhangETreebyBCoxBPedleyB. In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy. J Biomed Opt. 2012;17(5):056016.
22.
WangXChamberlandDLJamadarDA. Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis. Opt Lett. 2007;32(20):3002-4.
23.
ManoharSWilleminkRGHvan der HeijdenFSlumpCHvan LeeuwenTG. Concomitant speed-of-sound tomography in photoacoustic imaging. Appl Phys Lett. 2007;91:131911.
24.
JoseJWilleminkRGHResinkSPirasDvan HespenJCGSlumpCH. Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption. Opt Express. 2011;19(3):2093-104.
NusterRSchmitnerNWurzingerGGrattSSalvenmoserWMeyerD. Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection. J Biophotonics. 2013;6(6-7):549-59.
27.
Deán-BenXLNtziachristosVRazanskyD. Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers. J Biomed Opt. 2012;17(11):110504.
28.
FehmTFDeán-BenXLRazanskyD. Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe. Appl Phys Lett. 2014;105:173505.
29.
XiaJHuangCMaslovKAnastasioMAWangLV. Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array. Opt Lett. 2013;38(16):3140-3.
30.
Contreras OrtizSHChiuTFoxMD. Ultrasound image enhancement: a review. Biomed Signal Process Control. 2012;7(5):419-28.
31.
DuckFA. Physical Properties of Tissues: A Comprehensive Reference Book. San Diego, Academic Press; 1990 .
