A new method to characterize a material's attenuation using acoustic radiation force is proposed. Comparison of displacement magnitudes generated in a homogeneous material by acoustic radiation force excitations can be used to estimate the material's attenuation when the excitations are applied over a range of focal depths while maintaining a constant lateral focal configuration. Acoustic attenuations are related to the inverse of the excitation focal depth that yields the greatest focal zone displacement for this protocol. Experimental studies in calibrated tissue-mimicking phantoms are presented to demonstrate the feasibility of this method. Attenuations ranging from 0.3–1.5 dB/cm/MHz were characterized over excitation focal depths ranging from 5–30 mm, with an accuracy of 0.1 ± 0.15 dB/cm/MHz. As currently implemented, this method is limited to characterizing materials that have homogeneous material properties and acoustic attenuations. This method for characterizing acoustic attenuation can be performed using conventional diagnostic scanners without any additional hardware and could also be performed concurrently with acoustic radiation force-based imaging modalities to generate images of mechanical properties and attenuation that are spatially co-registered with B-mode images.
ViolaFWalkerWF. Radiation force imaging of viscoelastic properties with reduced artifacts, IEEE Trans Ultrason Ferroelec Freq Contr50, 736–742 (2003).
2.
SarvazyanARudenkoOSwansonSFowlkesJEmelianovS.Shear wave elasticity imaging: A new ultrasonic technology of medical diagnostics, Ultrasound Med Biol24, 1419–1435 (1998).
3.
BercoffJTanterMFinkM.Supersonic shear imaging: A new technique for soft tissue elasticity mapping, IIEEE Trans Ultrason Ferroelec Freq Contr51, 396–409 (2004).
4.
KonofagouEHynynenK.Localized harmonic motion imaging: theory, simulations, and experiments, Ultrasound Med Biol, 1405–1413 (2003).
5.
FaheyBNightingaleKMcAleaveySAcoustic radiation force impulse imaging of myocardial radiofrequency ablation: initial in vivo results, IEEE Trans Ultrason Ferroelec Freq Contr52, 631–641 (2005).
6.
NightingaleKBentleyRTraheyG.Observations of tissue response to acoustic radiation force: Opportunities for imaging, Ultrasonic Imaging24, 100–108 (2002).
7.
TraheyGPalmeriMBentleyRNightingaleK.Acoustic radiation force impulse imaging of the mechanical properties of arteries: in vivo and ex vivo results, Ultrasound Med. Biol30, 1163–1171 (2004).
8.
MelodelimaDBamberJDuckFShipleyJXuL.Elastography for breast cancer dianosis using radiation force: system development and performance evaluation, Ultrasound Med Biol32, 387–396 (2006).
9.
MadsenEFrankGDongFInterlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements, J Ultrasound Med18, 615–631 (1999).
10.
LizziFKingDRorkeMHuiJComparison of theoretical scattering results and ultrasonic data from clinical liver examinations, Ultrasound Med Biol14, 377–385 (1988).
11.
FournierCBridalSCoronALaugierP.Optimization of attenuation estimation in reflection for in vivo human dermis characterization of 20 MHz, IEEE Trans Ultrason Ferroelec Freq Contr50, 408–418 (2003).
12.
CloostermansMThijssenJ.A beam corrected estimation of the frequency dependent attenuation of biological tissues from backscattered ultrasound, Ultrasonic Imaging5, 136–147 (1983).
13.
FujiYTaniguchiNItohKShigetaKA new method for attenuation coefficient measurement in the liver: comparison with the spectral shift central frequency method, J Ultrasound Med21, 783–788 (2002).
14.
FlaxSPelcNGloverGGutmannFMcLachlanM.Spectral characterization and attenuation measurements in ultrasound, Ultrasonic Imaging, 5, 95–116 (1983).
15.
FinkMHottierFCardosoJ.Ultrasonic signal processing for In Vivo attenuation measurement: Short time fourier analysis, Ultrasonic Imaging5, 117–135 (1983).
16.
D'AstousFFosterF.Frequency dependence of ultrasound attenuation and backscatter in breast tissue, Ultrasound Med Biol12, 795–808 (1986).
17.
ParkerK.Ultrasonic attenuation and absorption in liver tissue, Ultrasound Med Biol9, 363–369 (1983).
18.
JangHSongTParkS.Ultrasound attenuation estimation in soft tissue using the entropy difference of pulsed echoes between two adjacent envelope segments, Ultrasonic Imaging, 10, 248–264 (1988).
19.
HePGreenleafJ.Attenuation estimation on phantoms — a stability test, Ultrasonic Imaging8, 1–10 (1986).
20.
KremkauFBarnesRMcGrawC.Ultrasonic attenuation and propagation speed in normal human brain, J Acoust Soc Am70, 29–38 (1981).
21.
LyonsMParkerK.Absorption and attenuation in soft tissues ii — experimental results, IEEE Trans Ultrason Ferroelec Freq Contr35, 511–521 (1988).
22.
BarannikEAGirnykATovstiakVDoppler ultrasound detection of shear waves remotely induced in tissue phantoms and tissue in vitro, Ultrasonics40, 849–852 (2002).
23.
AlizadAFatemiMNishimuraRADetection of calcium deposits on heart valve leaflets by vibro-acoustography: an in vitro study, J Am Soc Echocardiogr15, 1391–1395 (2002).
24.
CalleSRemenierasJMatarODefontaineMPatalF.Application of nonlinear phenomena induced by focused ultrasound to bone imaging, Ultrasound Med Biol.29, 465–472 (2003).
25.
FatemiMGreenleafJ.Vibro-acoustography: an imaging modality based on ultrasound-stimulated acoustic emission, Proc Natl Acad Sci96, 6603–6608 (1999).
26.
FaheyBNightingaleKStutzDTraheyG.Acoustic radiation force impulse imaging of thermally-and chemically-induced lesions in soft tissues: preliminary ex vivo results, Ultrasound Med Biol30, 321–328 (2004).
27.
LizziFMuratoreRDengCRadiation-force technique to monitor lesions during ultrasonic therapy, Ultrasound Med Biol29, 1593–1605 (2003).
28.
DaytonPKlibanovABrandenburgerGFerraraK.Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles, Ultrasound Med Biol25, 1195–1201 (1999).
ShortencarierMDaytonPBlochSA method for radiation-force localized drug delivery using gas-filled lipospheres, IEEE Trans Ultrason Ferroelec Freq Contr51, 822–831 (2004).
31.
NyborgW.Acoustic streaming, in NyborgW. Ed., Physical Acoustics, pp. 265–331 (Academic Press Inc, New York, 1965).
32.
PalmeriMSharmaABouchardRNightingaleRNightingaleK.A finite-element method model of soft tissue response to impulsive acoustic radiation force, IEEE Trans Ultrason Ferroelec Freq Contr52, 1699–1712 (2005).
33.
PalmeriM.Imaging the mechanical properties of tissue with ultrasound: an investigation of the response of soft tissue to acoustic radiation force, Ph.D. thesis (Duke University, 2005.)
34.
PalmeriMMcAleaveySTraheyGNightingaleK.Ultrasonic tracking of acoustic radiation force-induced displacements in homogeneous media, IEEE Trans Ultrason Ferroelec Freq Contr53, 1300–1313 (2006).
35.
PintonGDahlJTraheyG.Rapid tracking of small displacements with ultrasound, IEEE Trans Ultrason Ferroelec Freq Contr53, 1103–1117 (2006).
36.
NCRP.Report No. 140: Exposure Criteria for Medical Diagnostic Ultrasound: II. Criteria Based on All Known Mechanisms.National Council on Radiation Protection and Measurements, NCRP Publications, Bethesda, MD 20814, (2002).
37.
WalkerWTraheyG.A fundamental limit on delay estimation using partially correlated speckle signals, IEEE Trans Ultrason Ferroelec Freq Contr42, 301–308 (1995).
38.
McAleaveySNightingaleKTraheyG.Estimates of echo correlation and measurement bias in acoustic radiation force impulse imaging, IIEEE Trans Ultrason Ferroelec Freq Contr50, 631–641 (2003).
39.
NightingaleKPalmeriMTraheyG.Analysis of contrast in images generated with transient acoustic radiation force, Ultrasound Med Biol32, 61–72 (2006).
