The 1993 ASPEN Research Workshop examined research and clinical advances in the study of human body composition. The workshop had two themes: (1) compartments of the body and their measurement, and (2) clinical applications of body composition measurements. There were 12 speakers of varied backgrounds who gave short lectures followed by panel discussions. Speakers explored the validity and potential uses of new body composition methodologies, including dual-energy x-ray absorptiometry, multiple frequency bioimpedance analysis, computerized axial tomography, magnetic resonance imaging, nuclear magnetic resonance spectroscopy, neutron inelastic scattering, and gamma-ray resonance. The application of these methods to chronically and acutely ill hospitalized patients was described. The study of body composition is an emerging distinct research area within the broad study of human biology. This conference provided an overview of important new advances in the study of human body composition. (Journal of Parenteral and Enteral Nutrition18:91-103, 1994)
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References
1.
Wang Z., Pierson RN Jr, Heymsfield SB: The five level model: A new approach to organizing body composition research . Am J Clin Nutr56:19-28, 1992
2.
Heymsfield SB , Waki M., Kehayias J., et al: Chemical and elemental analysis of humans in vivo using improved body composition models. Am J Physiol261:E190-E198, 1991
3.
Heymsfield SB , Lichtman S., Baumgartner RN, et al: Body composition of humans: Comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure. Am J Clin Nutr52:52-58, 1990
4.
Cohn SH, Vartsky D., Yasumura S., et al: Compartmental body composition based on total body nitrogen, potassium, and calcium. Am J Physiol239:E524-E530, 1980
5.
Heymsfield SB , Wang J., Aulet M., et al: Dual photon absorptiometry: Validation of mineral and fat measurements. IN Advances in In Vivo Body Composition Studies, Yasumura S, Harrison JE, McNeill KG, et al (eds). Plenum Press, New York, 1990, pp 327-337
6.
Heymsfield SB , Waki M.: Body composition in humans: Advances in the development of multicompartment chemical models. Nutr Rev49:97-108, 1991
7.
Fuller NJ, Jebb SA, Laskey A. et al: Four-component model for the assessment of body composition in humans: Comparison with alternative methods, and evaluation of the density and hydration of fat-free mass. Clin Sci82:687-693, 1992
8.
Wang Z., Heshka S.Heymsfield SB: Application of computerized axial tomography in the study of body composition: Evaluation of lipid. water, protein, and mineral in healthy men . IN Human Body Composition: In Vivo Methods. Models, and Assessment, Ellis KJ.Eastman JD (eds). Plenum Press, New York . 1993, pp 343-344
9.
Shulman GI, Rothman DL, Jue T., et al: Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med322:223-228, 1990
10.
von Hevesy G. , Hofer E.: Die Verweilzeit des Wassers in menschlichen Körper, untersucht mit hilfe von "schwerem" wasser als indicator . Klin Wochenschr13:1524-1526, 1934
11.
Moore FD: Determination of total body water and solids with isotopes. Science104:157-160, 1946
12.
Forbes GB: Human Body Composition: Growth, Aging, Nutrition, and Activity. Springer-Verlag, New York, 1987, pp 5-100
13.
Pace N., Kline L., Schachman HK, et al: Studies on body composition. IV. Use of radioactive hydrogen for measurement in vivo of total body water. J Biol Chem168:459-469, 1947
14.
Lifson N., Gordon GB, McClintock R.: Measurement of total carbon dioxide production by means of D218O. J Appl Physiol7:704-710, 1955
15.
Schoeller DA , Van Santen E., Peterson DW, et al: Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr33:2686-2693, 1980
16.
Culebras JM , Moore FD: Total body water and the exchangeable hydrogen. I. Theoretical calculation of nonaqueous exchangeable hydrogen in man. Am J Physiol232:R54-R59, 1977
17.
Culebras JM , Fitzpatrick GF, Brennan MF, et al: Total body water and the exchangeable hydrogen. II. A review of comparative data from animals based on isotope dilution and desiccation, with a report of new data from the rat. Am J Physiol232:R60-R65, 1977
18.
Schoeller DA , Van Santen E.: Measurement of energy expenditure in humans by doubly labeled water method. J Appl Physiol53:955-959, 1982
19.
Prentice AM: The Doubly-Labelled Water Method for Measuring Energy Expenditure: Technical Recommendations for Use in Humans. NAHRES-4 International Atomic Energy Association, Vienna, 1990, pp 1-301
20.
Goran MI, Poehlman ET, Nair KS, et al: Effect of gender, body composition, and equilibration time on the 2H-to-18O dilution space ratio. Am J Physiol263:E1119-E1124, 1992
21.
Pace N., Rathbun EN: Studies on body composition. III. The body water and chemically combined nitrogen content in relation to fat content. J Biol Chem158:685-691, 1945
22.
Sheng HP, Huggins RA: A review of body composition studies with emphasis on total body water and fat. Am J Clin Nutr32:630-647, 1979
23.
Moore FD: Energy and the maintenance of the body cell mass. JPEN4:228-260, 1980
24.
Schoeller DA , Dietz W., Van Santen E., et al: Validation of saliva sampling for total body water determination by H218O dilution. Am J Clin Nutr35:591-594, 1982
25.
Heymsfield SB, Lichtman S., Baumgartner RN, et al: Body composition of humans: Comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure. Am J Clin Nutr52:52-58, 1990
26.
Elia M.: Body composition analysis: An evaluation of 2 component models, multicomponent models and bedside techniques. Clin Nutr11:114-127, 1992
27.
Heymsfield SB, Waki M.: Body composition in humans: Advances in the development of multicompartment chemical models. Nutr Rev49:97-108, 1991
28.
Kushner RF: Bioelectrical impedance analysis: A review of principles and applications . J Am Coll Nutr11:199-209, 1992
29.
Chumlea WC, Baumgartner RN, Roche AF: Specific resistivity used to estimate fat-free mass from segmental body measures of bioelectric impedance. Am J Clin Nutr48:7-15, 1988
30.
Baumgartner RN, Chumlea WC, Roche AF: Bioelectric impedance phase angle and body composition. Am J Clin Nutr48:16-23, 1988
31.
Baumgartner RN, Chumlea WC, Roche AF: Estimation of body composition from bioelectric impedance of body segments. Am J Clin Nutr50:221-226, 1989
32.
Scheltinga MR, Jacobs DO, Kimbrough TD, et al: Alterations in body fluid content can be detected by bioelectrical impedance analysis . J Surg Res50:461-468, 1991
33.
Moore FD, Boyden CM: Body cell mass and limits of hydration of the fat-free body: Their relation to estimated skeletal weight. IN Body Composition , Whipple HE.Silverzweig S , Brozek J (eds). New York Academy of Sciences, New York . 1963, pp 62-71
34.
McCullough AJ, Mullen KD, Kalhan SC: Measurements of total body and extracellular water in cirrhotic patients with and without ascites . Hepatology14:1102-1111, 1991
35.
Segal KR, Burastero S., Chun A., et al: Estimation of extracellular and total body water by multiple-frequency bioelectrical-impedance measurement. Am J Clin Nutr54:26-29, 1991
36.
Johnson HL, Virk SPS, Mayclin P., et al: Predicting total body water and extracellular fluid volumes from bioelectrical measurements of the human body. J Am Coll Nutr11:539-547, 1992
37.
Kehayias JJ , Heymsfield SB, LoMonte AF, et al: In vivo determination of body fat measuring total body carbon. Am J Clin Nutr53:1339-1344, 1991
38.
Kehayias JJ : Aging and body composition: Possibilities for future studies. J Nutr123:454-458, 1993
39.
Pichard C., Hoshino E., Allard PJ, et al: Intracellular potassium and membrane potential in rat muscles during malnutrition and subsequent refeeding. Am J Clin Nutr54:489-498, 1991
40.
Cummings SR , Rubin SM, Black D.: The future of hip fractures in the United States: Numbers, costs and potential effects of postmenopausal estrogen. Clin Orthop252:163-166, 1990
41.
Johnson CC, Slemenda CW, Melton LJ: Clinical use of bone densitometry. N Engl J Med324:1105-1109, 1991
42.
Lang P., Steiger P., Faulkner K., et al: Osteoporosis: Current techniques and recent developments in quantitative bone densitometry. Radiol Clin North Am29:49-76, 1991
43.
Santoris DJ , Moscona A., Resnick LD: Progress in radiology: Dual-energy radiographic absorptiometry for bone densitometry. Ann NY Acad Sci592:307-325, 1990
44.
Lukaski HC: Soft tissue composition and bone mineral status: Evaluation by dual-energy X-ray absorptiometry. J Nutr123:438-443, 1993
45.
Dawson-Hughes B., Dallal GE, Krall EA, et al: A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med323:878-883, 1990
46.
Dawson-Hughes B., Dallal GE, Krall EA, et al: Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med115:505-512, 1991
47.
Lukaski HC, Hall CB, Siders WA: Assessment of body composition by quantitative digital radiography during weight loss in obese women. Med Sci Sports Exerc23:S107, 1991
48.
Heymsfield SB, Smith R., Aulet M., et al: Appendicular skeletal muscle mass: Measurement by dual-photon absorptiometry. Am J Clin Nutr52:214-218, 1990
49.
Kellie SE: Measurement of bone density with dual-energy x-ray absorptiometry . JAMA267:286-294, 1992
50.
Saitta JC, Ott SM, Sherrard DJ, et al: Metabolic bone disease in adults receiving long-term parenteral nutrition: Longitudinal study with regional densitometry and bone biopsy. JPEN17:214-219, 1993
51.
Segal KR, Gutin B., Nyman AM, et al: Thermic effect of food at rest, during exercise, and after exercise in lean and obese men of similar body weight. J Clin Invest76:1107-1112, 1985
52.
Segal KR, Gutin B., Albu J., et al: Thermic effects of food and exercise in lean and obese men of similar lean body mass. Am J Physiol252:E110-E117, 1987
53.
Segal KR, Albu J., Chun A., et al: Independent effects of obesity and insulin resistance on postprandial thermogenesis in men. J Clin Invest89:824-833, 1992
54.
Welle S., Nair KS: Relationship of resting metabolic rate to body composition and protein turnover . Am J Physiol258:E990-E998, 1990
55.
Roubenoff R. , Kehayias JJ, Cannon JG, et al: Interleukin-1 beta and tumor necrosis factor-alpha reduce energy intake and elevate resting energy expenditure in rheumatoid arthritis. FASEB J7:A725, 1993
56.
Roubenoff R. : Hormone, cytokines, and body composition: Can lessons from illness be applied to aging?J Nutr123:469-473, 1993
57.
Sjöström L. : A computer-tomography based multicompartment body composition technique and anthropometric predictions of lean body mass, total and subcutaneous adipose tissue. Intern J Obesity15:19-30, 1991
58.
Gillies RJ: Nuclear magnetic resonance and its applications to physiological problems . Annu Rev Physiol54:733-748, 1992
59.
Koretsky AP , Williams DS: Application of localized in vivo NMR to whole organ physiology in the animal. Annu Rev Physiol54:799-826, 1992
60.
Alger JR, Frank JA: The utilization of magnetic resonance imaging in physiology. Annu Rev Physiol54:827-846, 1992
61.
Baumgartner RN , Rhyne RL, Garry PJ, et al: Imaging techniques and anatomical body composition in aging. J Nutr123:444-448, 1993
62.
Ingwall JS: Phosphorus nuclear magnetic resonance spectroscopy of cardiac and skeletal muscles. Am J Physiol242:H729-H744, 1982
63.
Rothman DL, Magnusson I., Katz LD, et al: Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science254:573-576, 1991
64.
Magnusson I. , Rothman DL, Katz LD, et al: Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest90:1323-1327, 1992
65.
Jue T., Rothman DL, Shulman GI, et al: Direct observation of glycogen synthesis in human muscle with 13C NMR. Proc Natl Acad Sci USA86:4489-4491, 1989
66.
Jacobs DO, Maris J., Fried R., et al: In vivo phosphorus-31 magnetic resonance spectroscopy of rat hind limb skeletal muscle during sepsis. Arch Surg123:1425-1428, 1988
67.
Jacobs DO, Kobayashi T., Imagire J., et al: Sepsis alters skeletal muscle energetics and membrane function . Surgery110:318-326, 1991
68.
Nishio ML, Jeejeebhoy KN: The effect of acute fasting vs hypocaloric feeding on skeletal muscle relaxation rate. J Physiol71:204-209, 1991
69.
Nishio ML, Jeejeebhoy KN: Effect of malnutrition on aerobic and anaerobic performance of fast- and slow-twitch muscles from rats. JPEN16:219-225, 1992
70.
Jeejeebhoy KN, Baker JP, Wolman SL, et al: Critical evaluation of the role of clinical assessment and body composition studies in patients with malnutrition and after total parenteral nutrition. Am J Clin Nutr35:1117-1127, 1982
71.
Russell Dmcr , Prendergast PJ, Darby PL, et al: A comparison between muscle function and body composition in anorexianervosa: The effect of refeeding. Am J Clin Nutr38:229-237, 1983
72.
Fong CN, Atwood HL, Jeejeebhoy KN, et al: Nutrition and muscle potassium: Differential effect in rat slow and fast muscles. Can J Physiol Pharmacol65:2188-2190, 1987
73.
Windsor JA, Hill GL:. Weight loss with physiologic impairment: A basic indicator of surgical risk . Ann Surg207:290-296, 1988
