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Abstract

The regulation of net hepatic glucose uptake in vivo occurs by way of the hormonal milieu (insulin and glucagon), the glucose level, and the route of glucose delivery. Hyperglycemia in the absence of changes in pancreatic hormones (i.e., increased insulin and/or decreased glucagon) does not elicit significant glucose uptake by the liver. Net hepatic glucose uptake is augmented in a dose-dependent manner by a rise in insulin and is further stimulated by the presence of a "portal signal." The presence of coordinated changes in insulin, glucagon, and the glucose level in combination with the "portal signal" ensures adequate glucose uptake by the liver in response to a meal. (Journal of Parenteral and Enteral Nutrition 15:71S-73S,1991)

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References

DeFronzo RA , Ferrannini E. , Hendler R. , et al: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45, 1983

Shulman GI , Lacy WW , Liljenquist JE , et al: Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest 65:496-505, 1980

Adkins-Marshall BA , Myers SR , Hendrick GK , et al: Interaction between insulin and the route of glucose delivery in the regulation of net hepatic glucose uptake in the conscious dog. Diabetes 39:87-95, 1990

McGuinness OP , Myers SR , Neal D. , et al: Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity. Metabolism 39:931-937, 1990

McGuinness OP , Ivy R. , Mari A. , et al: The error in estimating endogenous glucose production using 3-3H glucose during the euglycemic hyperinsulinemic clamp. Diabetes 36:28, 1987

DeFronzo RA , Ferrannini E. , Hendler R. , Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci USA 85:5173-5177, 1978

Cherrington AD , Williams PE , Abou-Mourad N. , et al: Insulin as a mediator of hepatic glucose uptake in the conscious dog. Am J Physiol 242:E97-E101, 1982

Bergman RN , Beir JR , Hourigan PM : Intraportal glucose infusion matched to oral glucose absorption: Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes 31:27-35, 1982

Ishida T. , Chap Z. , Chou KJ : Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs. J Clin Invest 72:590-601, 1983

10.

Barrett EJ , Ferrannini E. , Gusberg R. , et al: Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog. Metabolism 34:410-420, 1985

11.

Abumrad NN , Cherrington AD , Williams PE , et al: Absorption and disposition of a glucose load in the conscious dog. Am J Physiol 242:E398-E406, 1982

12.

Adkins BA , Myers SR , Hendrick GK , et al: Importance of the route of intravenous glucose delivery on hepatic glucose balance in the conscious dog. J Clin Invest 79:557-565, 1987

13.

Myers SR , McGuinness OP , Neal D. , et al: Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest, 87:930-939, 1991

14.

Rossetti L. : Influence of route of glucose administration on hepatic and peripheral glucose uptake in normal and diabetic rats. Diabetes 38:58A, 1989

15.

Pagliassotti MJ , Myers SR , Moore MC , et al: The rate of portal glucose entry can alter net hepatic glucose uptake despite constant hepatic glucose and insulin loads. Diabetes, 39:84A, 1990

Factors Which Regulate Net Hepatic Glucose Uptake In Vivo

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