Rose WC: The nutritive significance of the amino acids and certain related compounds . Science86:298-300, 1937
2.
Borman A., Wood T., Blank H., et al: The role of arginine in growth with some observations on the effect of arginoic acid. J Biol Chem166:585-594, 1946
3.
Morris JG, Rogers QR: Ammonia intoxication in the near adult cat as a result of a dietary deficiency of arginine. Science199:431-432, 1978
4.
Iyamu JO, Adamson I.: Effect of supplemental arginine on rehabilitation of the starved rat . Nutr Rep Int26:335-345, 1982
5.
Ha YH, Milner JA: Arginine requirements in immature dogs. J Nutr108:203-210, 1978
6.
Fahey JL: Toxicity and blood ammonia rise resulting from intravenous amino acid administration in man: The protective effect of L-arginine. J Clin Invest36:1647-1655, 1957
7.
Batshaw ML, Brusilow SW, Wabert L., et al: Treatment of hyperammonemic coma caused by inborn errors of urea synthesis. J Pediatr87:893-900, 1980
Levenson SM, Rettura G., Barbul A., et al: Citrulline replaces arginine as dietary essential in rats: Ornithine does not. Fed Proc39:726, 1980
10.
Kari FW, Ulman EA, Mulloy AL, et al: Arginine requirement of mature protein-malnourished rats for maximal rate of repletion. J Nutr111:1489-1493, 1981
11.
Steffee CH, Wissler RW, Humphreys EM, et al: Studies in amino acid utilization, V: The determination of minimum daily essential amino acid requirements in protein depleted adult male albino rats. J Nutr40:483-497, 1950
12.
Seifter E., Returra G., Barbul A., et al: Arginine: An essential amino acid for injured rats. Surgery84:224-230, 1978
13.
Chyun JH, Griminger P.: Improvement of nitrogen retention by arginine and glycine supplementation and its relation to collagen synthesis in traumatized mature and aged rats . J Nutr144:1687-1704, 1984
14.
Rettura G., Stratford F., Levenson SM, et al: Improved wound healing, anti-catabolic and thymotrophic actions of supplemental ornithine. Presented at the 17th Mid Atlantic Regional Meeting, American Chemical Society, April 6-8, 1983, White Haven, PA
15.
Elsair J., Poey J., Issad H., et al: Effect of arginine chlorohydrate on nitrogen balance during the three days following routine surgery in man. Biomed Express29:312-317, 1978
16.
Daly JM, Reynolds J., Thom A., et al: Immune and metabolic effects of arginine in the surgical patient . Ann Surg208:512-523, 1988
17.
Wernerman J. , Hammarquist F., Decken A., et al: Ornithine-alpha ketoglutarate improves skeletal muscle protein synthesis as assessed by ribosome analysis and nitrogen use after surgery. Ann Surg206:674-678, 1987
18.
Barbul A., Lazarou S., Efron DT, et al: Arginine enhances wound healing in humans and lymphocyte immune responses. Surgery, in press
19.
Albina JE, Milles CD, Barbul A., et al: Arginine metabolism in wounds. Am J Physiol254:(Endocrinol Metab 17)E459-E467, 1988
20.
Rojkind M., DeLeon D.: Collagen biosynthesis in cirrhotic rat liver slices: A regulatory mechanism . Biochim Biophys Acta217:512-522, 1970
21.
Salvemini D. , DeNucci G., Gryglewski RJ, et al: Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor . Proc Natl Acad Sci USA88:6328-6332, 1989
22.
Palmer RMJ , Rees DD, Ashton DS, et al: L-Arginine is the physi ologic precursor for the formation of nitric oxide in endothelium dependent relaxation. Biochem Biophys Res Commun153:1251-1256, 1988
23.
Barbul A., Rettura G., Levenson SM, et al: Wound healing and thymotrophic effects of arginine: A pituitary mechanism of actionAm J Clin Nutr37:786-794, 1983
24.
Merimee TJ, Lillicrap DA, Rabinowitz D.: Effects of arginine on serum levels of human growth hormone. Lancet2:688, 1965
25.
Prudden JF, Nishihara G., Ocampo L.: Studies on growth hormone III: The effect on wound tensile strength of marked postoperative anabolism induced with growth hormone. Surg Obstet Gyneco107:481-484, 1958
26.
Barbul A., Rettura G., Levenson SM, et al: Arginine: Thymotrophic and wound healing promoting agent. Surg Forum28:101-103, 1977
27.
Barbul A., Wasserkug HL, Seifter E., et al: Immune stimulatory effects of arginine in normal and injured rats. J Surg Res29 :228-235, 1980
28.
Barbul A., Wasserkrug HL, Sisto DA, et al: Thymic and immune stimulatory actions of arginine. JPEN4:446-449, 1980
29.
Barbul A., Sisto DA, Wasserkrug HL, et al: Arginine stimulates thymic immune function and ameliorates the obesity and the hyperglycemia of genetically obese mice. JPEN5:492-495, 1981
30.
Barbul A., Efron JE, Shawe T., et al: Arginine increases the number of T-lymphocytes in nude mice . JPEN13:75, 1989
31.
Barbul A., Sisto DA, Wasserkrug HL, et al: Arginine stimulates lymphocyte immune response in healthy humans . Surgery90:244-251, 1981
32.
Barbul A.: Arginine and immune function. Nutrition6:S53-S58, 1990
33.
Cerra FB, Lehman S., Konstantinides N., et al: Effect of enteral nutrient on in vitro tests of immune function in ICU patients: A preliminary report. Nutrition6:S84-S87, 1990
34.
Madden HP, Breslin RJ, Wasserkrug HL, et al: Stimulation of T cell immunity enhances survival in peritonitis . J Surg Res44:658-663, 1988
35.
Saito H., Trocki O., Wang S., et al: Metabolic and immune effects of dietary arginine supplementation after burn. Arch Surg122:784-789, 1987
36.
Freund HR, Ryan JA, Fischer JE: Amino acid derangements in patients with sepsis. Ann Surg188:423-430, 1978
37.
Freund H., Atamian S., Holyroyde J., et al: Plasma amino acids as predictors of the severity and outcome of sepsis. Ann Surg190:571-576, 1979
Moriguchi S. , Mukai K., Hiraoka I., et al: Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine . Nutr Res7:719-729, 1987
40.
Drapier JC, Hibbs JB: Differentiation of murine macrophages to express non-specific cytotoxicity for tumor cells results in L-arginine dependent inhibition of mitochondrial iron-sulphur enzymes in the macrophage effector cells. J Immunol140:2829-28-38, 1988
41.
Hibbs JB, Vavrin Z., Taintor RR; L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells . J Immunol138:550-565. 1987
42.
Granger DLHibbs JB, Perfect JR, et al: Specific amino-acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. J Clin Invest81:1129-1136, 1988
43.
Marletta MA , Yoons PS, Iyengen R., et al: Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry27:8706-8711, 1988
44.
Barbul A.: Arginine: Biochemistry, physiology and therapeutic implications. JPEN10:227-238, 1986
45.
Hartman DP, Holaday JW, Bernton EW: Inhibition of lymphocyte proliferation by antibodies to prolactin . FASEB J3:2194-2202, 1989
46.
Bernton E., Meltzer M., Holaday JW: Suppression of macrophage activation and T lymphocyte function in hypoprolactinemic mice. Science239:401-404, 1988
47.
Barbul A., Wasserkrug HL, Yoshimura N., et al: High arginine levels in intravenous hyperalimentation abrogate post-traumatic immune suppression. J Surg Res36:624-630, 1984
48.
Moncada S., Palmer RMJ, Higgs AE: Biosynthesis of nitric oxide from L-arginine: A pathway for the regulation of cell function and communication. Biochem Pharmacol11:1709-1715, 1989
49.
Palmer RMJ , Moncada S.: A novel citrulline forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun158:348-352, 1989
50.
Kamoun PP, Schneidner E., Dy M.: Superoxide induced deimination of arginine in haemopoietic cells. FEBS Lett226:285-286, 1988
51.
Amber IJ, Hibbs JB Jr, Taintor RR, et al: The L-arginine dependent effector mechanism is induced in murine adenocarcinoma cells by culture supernatant from cytotoxic activated macrophages . J Leuk Biol43:187-192, 1988
52.
Varich VY, Vain AF, Orsyannikova LM: Discovery of endogenous nitrogen oxide in mouse liver by ESR method . Biofizika32:1062-1063, 1987
53.
Billiar TR, Curran RD, Stuehr DJ, et al: Evidence that activation of Kupffer cells results in production of L-arginine metabolites that release cell-associated iron and inhibit hepatocyte protein synthesis. Surgery106:364-372, 1989
