Alverdy JC, Aoys E., Moss G.: Total parenteral nutrition promotes bacterial translocation from the gut. Surgery104:185-190, 1988
2.
Anderson NM, Bennett FI, Alleyne GAO: Ammonia production by the small intestine of the rat. Biochim Biophys Acta437:238, 1976
3.
Babij P., Hundal HS, Rennie MJ, et al: Effects of corticosteroids on glutamine transport in rat skeletal muscle. J Physiol374:35P, 1986
4.
Baskerville A., Hambleton P., Benbough JE: Pathologic features of glutaminase toxicity . Br J Exp Pathol61:132, 1980
5.
Budohoski L. , Challis RAI, Newsholme EA: Effects of starvation on the maximal activities of some glycolytic and citric acid-cycle enzymes and glutaminase in mucosa of the small intestine of the rat. Biochem J206:169-172, 1982
6.
Burke D., Alverdy JC, Aoys E., et al: Glutamine-supplemented TPN improves gut immune function. Arch Surg124:1396-1399, 1989
7.
Cersosimo E. , Williams PE, Radosevich PM, et al: Role of glutamine in adaptations in nitrogen metabolism during fasting. Am J Physiol250:E622-E628, 1986
8.
Deitch EA, Winterton J., Li M., et al: The gut as a portal of entry for bacteremia: Role of protein malnutrition. Ann Surg205:681-692, 1987
9.
Deitch EA, Maejina K., Berg R.: Effect of oral antibiotics and bacterial overgrowth on the translocation of the GI microflora in burned rats. J Trauma25:385-392, 1985
10.
Deitch EA, Berg R.: Endotoxin but not malnutrition promotes bacterial translocation in the gut flora in burned mice. J Trauma27:161-166, 1987
11.
Felig P.: Amino acid metabolism in man. Annu Rev Biochem44:933, 1975
12.
Felig P., Warren J., Karl I., et al: Glutamine and glutamate metabolism in normal and diabetic subjects . Diabetes22:573-576, 1973
13.
Fox AD, Kripke SA, DePaula J., et al: Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis. JPEN12:325-331, 1988
14.
Fox AD, Kripke SA, Berman JM, et al: Dexamethasone administration induces increased glutaminase specific activity in the jejunum and colon. J Surg Res44:391-396, 1988
15.
Frisell WR: Synthesis and catabolism of nucleotides. IN Human Biochemistry , Frisell WR (ed). Macmillan, New York, 1982, pp 292-304
16.
Geer RJ, Williams PE, Lairmore T., et al: Glucagon: An important stimulator of gut and hepatic glutamine metabolism. Surg Forum38:27, 1988
17.
Ghishan FK, Sutter W., Said H., et al: Glutamine transport by rat basolateral membranes. Biochim Biophys Acta979:77-81, 1989
18.
Grant J.: Use of L-glutamine in total parenteral nutrition. J Surg Res44:506-513, 1988
19.
Hanson PJ, Parson SDS: Metabolism and transport of glutamine and glucose in vascularly perfused rats small intestine. Biochem J166:509-519, 1977
20.
Heitman RN, Bergmann AE: Glutamine metabolism interorgan transport and glucogenicity in the sheep. Am J Physiol234:E197-E203, 1978
21.
Hwang TL, O'Dwyer STSmith RJ et al: Preservation of small bowel mucosa using glutamine-enriched parenteral nutrition. Surg Forum38:56, 1987
22.
Jacobs DOEvans A.O'Dwyer ST et al: Disparate effects of 5-fluorouracil on the ileum and colon of enterally fed rats with protection by dietary glutamine. Surg Forum38:45-49. 1987
23.
Jacobs DO, Evans DA, Mealy K. et al: Combined effects of glutamine and epidermal growth factors (EGF) on GI mucosal cellularity. Surgery104:358-364, 1988
24.
Klimberg VS , Souba WW. Dolson DJ, et al: Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer, in press
25.
Klimberg VS , Souba WW, Sitren H., et al: Glutamine-enriched total parenteral nutrition supports gut metabolism. Surg Forum40:175-177, 1989
26.
Klimberg VS , Souba WW, Dolson DJ, et al: Oral glutamine supports crypt cell turnover and accelerates intestinal healing following abdominal radiation . JPEN13(suppl 1):35, 1989
27.
Klimberg VS , Souba WW, Hautamaki RD, et al: Dietary glutamine supports gut metabolism, structure, and function, promotes "bowel rescue," improves survival and decreases morbidity following abdominal radiation. Arch Surg, in review
28.
Lowe DL, Benfell K., Smith RJ, et al: Glutamine-enriched total parenteral nutrition is safe in normal humans. Surg Forum40:9-11, 1989
29.
Marliss EB, Aoki TT, Pozefsky T., et al: Muscle and splanchnic glutamine and glutamate metabolism in post-absorptive and starved man. J Clin Invest50:814, 1971
30.
Miller BM, Cersosimo E., McRae J., et al: Interorgan relationships of alanine and glutamine during fasting in the conscious dog. J Surg Res35:310, 1983
31.
Muhlbacher F., Kapadia CR, Colpoys MF, et al: Effects of glucocorticoids on glutamine metabolism in skeletal muscle. Am J Physiol247:E75-E83, 1984
32.
O'Dwyer ST, Scot T., Smith RJ, et al: 5-Fluorouracil toxicity on small intestinal mucosa but not white blood cells is decreased by glutamine (abstr). Clin Res35:369a, 1987
33.
Okabe S., Honda K., Takeuchi K., et al: Inhibitory effect of L-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat. Dig Dis20:626, 1975
34.
Pinkus LM, Windmueller HG: Phosphate-dependent glutaminase of small intestine and localization and role in intestinal glutamine metabolism. Arch Biochem Biophys182:506-517, 1977
35.
Plumley DA, Souba WW, Hautamaki RD, et al: Accelerated lung amino acid release in hyperdynamic septic surgical patients. Arch Surg125:57-61, 1990
36.
Plumley DA, Souba WW: Glucocorticoids accelerate lung amino acid release. Surgery , in press
37.
Salloum RM, Souba WW, Klimberg VS, et al: Glutamine is superior to glutamate in supporting gut metabolism, stimulating intestinal glutaminase activity, and preventing bacterial translocation . Surg Forum40:6, 1989
38.
Salloum RM, Souba WW, Fernandez A., et al: Dietary modulation of intestinal glutamine transport in intestinal brush border membrane vescicles (BBMV). J Surg Res, in press
39.
Shive W., Snider RN, DeBiller B., et al: Glutamine in treatment of peptic ulcer. Texas StateJ Med840-843, 1957
40.
Souba WW: Glutamine metabolism in catabolic states: Role of the intestinal tract. Thesis, Department of Nutritional Biochemistry, Harvard School of Public Health, Boston, June 1984
41.
Souba WW, Herskowitz K., Martin TD, et al: The effects of hypothermic anesthesia on gut fuel metabolism . Surg Forum1990 (in press)
42.
Souba WW, Herskowitz K., Klimberg VS, et al: The effects of sepsis and endotoxemia on gut glutamine metabolism . Ann Surg211:543-551, 1990
43.
Souba WW, Klimberg VS, Hautamaki RD, et al: Oral glutamine reduces bacterial translocation following abdominal radiation. J Surg Res48:1-5, 1990
44.
Souba WW, Klimberg VS, Plumley DA, et al: The role of glutamine in maintaining gut structure and function and supporting the metabolic response to injury and infection. J Surg Res48:383-391, 1990
45.
Souba WW, Scott TE, Wilmore DW: Intestinal consumption of intravenously administered fuels. JPEN9:18-22, 1985
46.
Souba WW, Smith R.J., Wilmore DW: Effect of glucocorticoids on glutamine metabolism in visceral organs . Metabolism34:450-456, 1985
47.
Souba WW, Smith RJ, Wilmore DW: Glutamine metabolism by the intestinal tract: Invited review. JPEN9:608-617, 1985
48.
Souba WW, Strebell FR, Bull J., et al: Interorgan glutamine metabolism in the tumor-bearing rat. J Surg Res44:720-726, 1988
49.
Souba WW, Wilmore DW: Postoperative alteration of arteriovenous exchange of amino acids across the gastrointestinal tract. Surgery94:342-350, 1983
Walker RI, Porvaznik MJ: Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin. Infect Immun21:655-658, 1978
52.
Welbourne TC , Childress D., Givens G.: Renal regulation of interorgan glutamine flow in metabolic acidosis. Am J Physiol251:R858-R866, 1988
53.
Welbourne TC , Phromphetcharat V., Givens G., et al: Regulation of interorgan glutamine flow in metabolic acidosis. Am J Physiol250(Endocrinol Metab13):E457-E463, 1986
54.
Welbourne TC : Interorgan glutamine flow in metabolic acidosis . Am J Physiol253:F1069-F1076, 1987
55.
Wilmore DW, Smith RJ, O'Dwyer ST, et al: The gut: A central organ after surgical stress. Surgery104:917-923, 1989
56.
Windmueller HG: Glutamine utilization by the small intestine . Adv Enzymol53:201-237, 1982
57.
Windmueller HG, Spaeth AE: Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. J Biol Chem255:107, 1980
58.
Windmueller HG, Spaeth AE: Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Arch Biophys Biochem171:662-672, 19675
59.
Yamamoto H. , Aikawa T., Matsutkalt J., et al: Relative uptake of plasma amino acids by fetal and tumor tissues. Metabolism23:1012, 1974
60.
Ziegler TR, Brown E., Smith E., et al: Metabolism of oral and iv glutamine in health humans. Fed Proc3:1248, 1989
