Restricted accessResearch articleFirst published online 1986-11
Plasma Phospholipid Fatty Acids and Urinary Excretion of Prostaglandins PGE 1 and PGE2 in Infants during Total Parenteral Nutrition,with Continuous or Sequential Administration of Fat Emulsion
During total parenteral nutrition, using an identical supply of fat emulsion (350 mg/kg/24 hr) to correct essential fatty acid deficiency in children, the efficacy of two methods of administration was studied: continuous over 24 hr, or discontinuous 3 hr/day. At the beginning of the study, all the infants (1-4 months old) had proven essential fatty acid deficiency. After at least 1 month of one of the two nutritional protocols (continuous or discontinuous), plasma phospholipid fatty acid composition and PGE1 and PGE 2 urinary excretion were measured. The results obtained indicate better utilization of the fat emulsion when it is administered almost every day, in continuous infusion over 24 hr (1 g/kg/24 hr of Intralipid 20%). ( Journal of Parenteral and Enteral Nutrition10:631-634, 1986)
Get full access to this article
View all access options for this article.
References
1.
Forget P., Fernandez J., Harerkamp P., et al: Utilisation of fat emulsion during total parenteral nutrition in children. Acta Paediatr Scand64:377-384, 1975
2.
Olegard R.Gustafson A., Kjellmer I., et al: Nutrition in low-birth-weight infants: Lipolysis and free fatty acid elimination after intravenous administration of fat emulsion. Acta Paediatr Scand64:745-751, 1975
3.
Nordenström J., Carpentier YA, Askanazi J., et al: Metabolic utilisation of intravenous fat emulsion during total parenteral nutrition. Ann Surg196:221-231, 1982
4.
Caldwell MD, Jonsson HT, Othersen HB: Essential fatty acid deficiency in an infant receiving prolonged parenteral alimentation. J Pediatr5:894-898, 1972
5.
Tashiro T., Ogata H., Yokoyama H., et al: The effect of emulsion (Intralipid) on essential fatty acid deficiency in infants receiving intravenous alimentation. J Pediatr Surg4:505-515, 1976
6.
Riella M., Miller R., Wells M., et al: Prevention of essential fatty acid deficiency during prolonged home parenteral nutrition. Acta Chir Scand494:60-62, 1979
7.
O'Neill JA, Caldwell MD, Meng HC: Essential fatty acid deficiency in surgical patients (children and adults). Ann Surg3:535-542, 1977
8.
Goodgame JT, Lowry SF, Brennan MF: Essential fatty acid deficiency in total parenteral nutrition: Time course of development and suggestions for therapy. Surgery2:271-277, 1978
9.
Stein TP, Busby GP, Hargrove WC, et al: Essential fatty acid deficiency in patients receiving simultaneous parenteral and oral nutrition. JPEN4:343-345, 1980
American Academy of Pediatrics.Committee on Nutrition. Use of intravenous fat emulsions in pediatric patients . Pediatrics5 :738-743, 1981
12.
Barr LH, Dunn GD, Brennan MF: Essential fatty acid deficiency during total parenteral nutrition . Ann Surg3:304-311, 1981
13.
Greig PD, Baker JP, Jeejeebhoy KN: Metabolic effects of total parenteral nutrition. Ann Rev Nutr2:179-199, 1982
14.
Ricour C., Duhamel JF: Nutritional problems. IN Care of the Critically III Patient . Tincker J, Rapin M (eds). Springer, Berlin, 1983, pp 1087-1103
15.
Ghisolfi J.: Apports nutritionnels et alimentation artificielle. XXVIIème Congrès des Pédiatres de Langue Française. Flammarion Editeur, Paris, 1984, pp 97-107
16.
Folch J., Lees M., Stanley GHS: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem226:497-499. 1957
17.
Powell WS: Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica. Methods Enzymol86:467-477, 1982
18.
Dray F., Charbonnel B., Maclouf J.: Radioimmuno assay of prostaglandins F2, E1, and E2 in human plasma . Eur J Clin Invest5:311-318, 1975
19.
Dray F.: Dosage radio immunologique des prostaglandines. Nouveaux developpements in "Les Prostaglandines et la reproduction humaine." Flammarion Ed, Paris, 1979, pp 47-64
20.
Andersen DW , Filer LJ, Steginck LD: Intravenous lipid emulsions in the treatment of essential fatty acid deficiency: Studies in young pigs . Pediatr Res18:1350-1355, 1984
21.
Yamanaka WK , Tilmont G., Aker SN: Plasma fatty acids of marrow transplant recipients on fat-supplemented parenteral nutrition. Am J Clin Nutr39:607-611, 1984
22.
Hansen HS: Dietary essential fatty acids and in vivo prostaglandins production . World Rev Nutr Diet42:102-134, 1983
23.
Hansen HS: Essential fatty acid supplemented diet increases renal excretion of prostaglandin E2 and water in essential fatty acid-deficient rats. Lipids11:849-854, 1981
24.
Ghisolfi J., Garcia J., Olives JP, et al: Intravenous essential fatty acids administration and urinary prostaglandins excretion in infants during total parenteral nutrition. Sixth Congress of the European Society of Parenteral and Enteral Nutrition, Milan, October 1-3, 1984
25.
Brouhard BH , Aplin CE, Cunningham RJ, et al: Immunoreactive urinary prostaglandins A and E in neonates, children and adults. Prostaglandins15:881-885, 1978
26.
Benzoni D., Vincent M., Betend B., et al: Urinary excretion of prostaglandins and electrolytes in developing children. Kidney20:386-391, 1981
27.
Godard C., Valloton MB, Farre L.: Urinary prostaglandins, vasopressin and kallikrein excretion in healthy children from birth to adolescence. J Pediatr100:898-902, 1982
28.
Friedman S. , Seyberth H., Lamberth EL, et al: Decreased prostaglandin E turnover in infants with essential fatty acid deficiency. Pediatr Res12:711-714, 1978
29.
Friedman Z. , Frölich JC: Essential fatty acids and the major urinary metabolites of the E prostaglandins in thriving neonates and in infants receiving parenteral fat emulsion. Pediatr Res13:932-936, 1979
30.
Friedman Z., Seyberg H., Frölich J., et al: Effects of dietary variation in linoleic acid content on the major urinary metabolites of the E prostaglandins (PGE-M) in infants. IN Advances in Prostaglandins and Thromboxan Research, vol 8, Samuelson (ed). Raven Press, New York, 1980, pp 1799-1805
31.
Friedman Z. : Essential fatty acid revisited. Am J Clin Nutr134:397-408, 1980
