The Effects of Oral Soybean Phospholipid on Serum Total Cholesterol,Plasma Triglyceride,and Serum High-Density Lipoprotein Cholesterol Concentrations in Hyperlipidemia
Restricted accessOtherFirst published online November, 1985
The Effects of Oral Soybean Phospholipid on Serum Total Cholesterol,Plasma Triglyceride,and Serum High-Density Lipoprotein Cholesterol Concentrations in Hyperlipidemia
In a randomized, double-blind, cross-over trial soybean phospholipid and placebo, 18 g daily for 6 wk, were given orally to 20 patients on long-term treatment with standard lipid lowering diets. The effect of this treatment on serum total cholesterol and high-density lipoprotein cholesterol and plasma triglyceride was studied. After 6 wk mean (±SE) cholesterol concentration was decreased by 0.54 (±0.19) mmol/ liter in phospholipid-treated as compared to placebo-treated patients (p < 0.02). The decrease in serum cholesterol was significant (p < 0.02) only in patients assigned to receive phospholipid before placebo. A highly significant increase (p < 0.001) followed the withdrawal of phospholipid. No effect on triglyceride and high-density lipoprotein cholesterol concentrations was demonstrated. (Journal of Parenteral and Enteral Nutrition9:716-719, 1985)
Get full access to this article
View all access options for this article.
References
1.
Kesten HD, Silbowitz R.: Experimental atherosclerosis and soya lecithin. Proc Soc Exp Biol Med49:71-3, 1942
2.
Samochowiec L., Kadlubowska D., Rozewicka L.: Investigations in experimental atherosclerosis. Part 1. The effects of phosphatidylcholine (EPL) on experimental atherosclerosis in white rats. Atherosclerosis23:305-17, 1976
3.
Samochowiec L., Kadlubowska D., Rozewicka L., et al: Investigations in experimental atherosclerosis. Part 2. The effect of phosphatidylcholine (EPL) on experimental atherosclerotic changes in miniature pigs. Atherosclerosis23:319-31, 1976
4.
Adams CWM , Baker RWR , Morgan RS, et al: The effect of oral polyunsaturated lecithin on the development of atheroma and fatty liver in the cholesterol-fed rabbit. J Pathol97:35-41, 1969
5.
Kritchevsky D., Tepper SA, Klurfeld DM, et al: Experimental atherosclerosis in rabbits fed cholesterol-free diets. 8. Effect of lecithin . Pharmacol Res Commun11:643-7, 1979
6.
Adlersberg D. , Sobotka H.: Effect of prolonged lecithin feeding on hypercholesterolemia . J Mount Sinai Hosp9:955-6, 1942
7.
Morrison LM: Serum cholesterol reduction with lecithin. Geriatrics13:12-19, 1958
8.
Davis O., Levine A., Bergal M., et al: Studies with a soyderived phosphatide in clinical hypercholesterolemia . Illinois Med J127:567-9, 1965
9.
Simons LA, Hickie JB, Ruys J.: Treatment of hypercholesterolemia with oral lecithin. Aust NZ J Med7:262-6, 1977
10.
Hirsch MJ, Growdon JH, Wurtman RJ: Relations between dietary choline or lecithin intake, serum cholesterol levels, and various metabolic indices. Metabolism27:953-60, 1978
11.
Cob M., Turkki P., Linscheer, W., et al: Lecithin supplementation in healthy volunteers. Effect on cholesterol esterification and plasma, and bile lipids. Nutr Metab24:228-37, 1980
12.
Svanberg U., Gustafson A., Ohlson R.: Polyunsaturated fatty acids in hyperlipoproteinemia. Nutr Metab17:338-46, 1974
13.
Childs MT, Bowlin JA, Ogilvie JT, et al: The contrasting effects of a dietary soya lecithin product and corn oil on lipoprotein lipids in normolipidemic and familial hypercholesterolemic subjects. Atherosclerosis38:217-28, 1981
14.
ter Welle HF , van Gent CM, Dekker W., et al: The effect of soya lecithin on serum lipid values in type II hyperlipoproteinemia. Acta Med Scand195:267-71, 1974
15.
Wallentin L. : Influence of intravenous and oral administration of phospholipids on lecithin: cholesterol acyl transfer rate in plasma. Artery3:40-51, 1977
16.
Greten H., Raetzer H., Stiehl A., et al: The effect of polyunsaturated phosphatidylcholine on plasma lipids and fecal sterol excretion. Atherosclerosis36:81-8, 1980
17.
Beaumont JL , Carlson LA, Cooper GR, et al: Classification of hyperlipidemias and hyperlipoproteinemias. Bull WHO43 :891-915, 1970
18.
Fredrickson DS , Levy RI, Bonnell M., et al. The Dietary Management of Hyperlipoproteinemia. A Handbook for Physicians and Dietitians . U.S. Dept. of Health, Education and Welfare, Public Health Service, Washington D.C., U.S. Government Printing Office, 1973
19.
Folch J., Lees M., Sloane Stanley GH: A simple method for the isolation and purification of total lipids from animal tissue. Biol Chem226:497-509, 1957
20.
Rouser G., Fleischer S., Yamamoto A.: Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids5:494-6, 1970
21.
Høy C.-E. , Hølmer G.: Incorporation of cis- and trans-octadecenoic acids into the membranes of rat liver mitochondria. Lipids14 :727-33, 1979
22.
Høy C.-E. , Hølmer G.: Incorporation of cis-octadecenoic acids into the rat liver mitochondrial membrane phospholipids and adipose tissue triglycerides . Lipids16:102-8, 1981
23.
Høy C.-E. , Hølmer G., Kaur N., et al: Acyl group distributions in tissue lipids of rats fed evening primrose oil (γ-linolenic plus linoleic acid) or soybean oil (α-linolenic plus linoleic acid). Lipids18:761-71, 1983
24.
Burstein M. , Scholnik HR, Morfin R.: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions . J Lipid Res11:583-95, 1970
Wallentin L. , Vikrot O.: Influence of fat ingestion on lecithin:cholesterol acyl transfer rate in plasma of normal persons. Scand J Clin Lab Invest36:473-80, 1976
27.
Jackson RL, Taunton OD, Morrisett JD, et al: The role of dietary polyunsaturated fat in lowering blood cholesterol in man. Circ Res42:447-53, 1978
28.
Shepherd J. , Packard CJ, Grundy SM, et al: Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. J Lipid Res21:91-9, 1980
29.
Wong EK, Nicolosi RJ, Low PA, et al: Lecithin influence on the hyperlipemia in Rhesus monkeys. Lipids15:428-33, 1980
30.
Imaizumi K. , Murata M., Sugano M.: Effect of dietary polyunsaturated phospholipid on the chemical composition of serum lipoproteins in rat. J Nutr Sci Vitaminol28:281-94, 1982
31.
Keys A., Anderson JT, Grande F.: Prediction of serum cholesterol responses of man to change in fats in the diet. Lancet2:959-66, 1957
32.
Rodgers JB, O'Connor PJ: Effect of phosphatidylcholine on fatty acid and cholesterol absorption from mixed micellar solutions. Biochim Biophys Acta409:192-200, 1975
33.
Clark SB: Chylomicron composition during duodenal triglyceride and lecithin infusion . Am J Physiol235:E183-90, 1978
34.
Beil FU, Grundy SM: Studies on plasma lipoproteins during absorption of exogenous lecithin in man. J Lipid Res21:525-36, 1980
35.
Rampone AJ, Machida CM: Mode of action of lecithin in suppressing cholesterol absorption. J Lipid Res22:744-52, 1981
36.
Murata M., Imaizumi K., Sugano M.: Effect of dietary phospholipids and their constituent bases on serum lipids and apolipoproteins in rats. J Nutr112:1805-8, 1982
