Bleeding Disorder from the "Fat Overload" Syndrome

Abstract

The fat overload syndrome developed in a 7-yr-old girl receiving total parenteral nutrition with 20% Intralipid. She developed a bleeding disorder characterized by severe hematemesis that appeared to be due to abnormal platelet function associated with platelet phagocytosis of lipid demonstrable by electron microscopy. The platelet defect and bleeding reversed when the lipemia cleared. (Journal of Parenteral and Enteral Nutrition 8:447-449, 1984)