A study was performed comparing the elimination kinetics of two soybean oil/egg phosphatide lipid emulsions (10% Travamulsion υs 10% Intralipid) from the vascular compartment of the dog. Elimination kinetics were evaluated after bolus injection and after continuous infusion studies. Evaluation of triglyceride and free fatty acid data indicates the emulsions are similar metabolic substrates. Phospholipid and cholesterol data indicate a possible difference in remnant particle removal. At the higher lipid dosages, remnant particles from Travamulsion injection were removed at a faster rate than those from Intralipid. (Journal of Parenteral and Enteral Nutrition 8: 140-145, 1984)
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References
1.
Thompson SW : General characteristics of lipid emulsions intended for intravenous administration. IN The Pathology of Parenteral Nutrition with Lipids. Springfield, IL, Charles C Thomas, 1974, p 11-21
2.
Meng HC, Kaley JS: Effects of multiple infusions of a fat emulsion on blood coagulation, liver function, and urinary excretion of steroids in schizophrenic patients . Am J Clin Nutr16:156-164, 1965
3.
Schuberth O. : Clinical results of intravenous infusion of fat emulsions. Nutr Dieta5:387-402, 1963
4.
Hallberg D.: Elimination of exogenous lipids from the blood stream. Acta Physiol Scand65:1-23, 1965
5.
Carlson LA, Hallberg D.: Studies on the elimination of exogenous lipids from the blood stream: the kinetics of elimination of a fat emulsion and of chylomicrons in the dog after a single intravenous injection. Acta Physiol Scand5:52-61, 1963
6.
Levy AL: Measurement of triglyceride using nonane extraction and colorimetry . Ann Clin Lab Sci2:474-479, 1972
7.
Mellentin WR : Basic Guide to Canine Nutrition. 4th ed. White Plains, NY, Gains Professional Services, 1977, p 6.
8.
Vazquez RM, Kaminski MV (ed): Peripheral parental nutrition. IN A Manual of Nutritional and Metabolic Support. Chicago, IL, Northwestern Memorial Hospital, 1978, p 38-42
9.
Duncombe WG: The colorimetric microdetermination of nonesterified fatty acids in plasma . Clin/Chim Acta9:122-125, 1964
10.
Cotter R., Martis L., Cosmas F., et al: Nonlinear elimination kinetics of intravenously-administered lipid emulsion in the dog. Fed Proc38:845, 1979
11.
Metzler CM, Elgring GL, McEwen AJ: A User's Manual for NON-LIN and Associated Programs. Kalamazoo MI, Upjohn, 1974
12.
Wagner JG: Fundamentals of Clinical Pharmacokinetics. Hamilton, IL , Intelligence Publications, 1975
13.
Zilversmit DB : V2, Phosphatides in plasma. IN Standard Methods of Clinical Chemistry. Seligson D , ed. New York, Academic Press , 1958, p 132-136
14.
Simonsen DG , Wertman M., Wectorey LM, et al: The determination of serum phosphate by the molybdivonadate method. J Biol Chem166:747-755, 1946
15.
Leffler HH: Estimation of cholesterol in serum. Am J Clin Pathol31:310-313, 1959
16.
Swenson MJ: Duke's Physiology of Domestic Animals. 9th ed. Ithaca, NY, Cornell University Press , 1979.
17.
Fielding CJ : Kinetics of lipoprotein lipase activity: effects of the substrate apoprotein on reaction velocity. Bioclin Biophys Acta316:66-75, 1973
18.
Fielding CJ : Lipoprotein lipase: Evidence for high and low-affinity enzyme sites. Biochemistry15:879-884, 1976
19.
Brown MS, Petri TK, Goldstein JL: Regulation of plasma cholesterol by lipoprotein receptors. Science112:628-635, 1981
