Serum-sulfated lithocholate concentrations were followed in 55 patients receiving parenteral nutrition. Elevation of serum lithocholate occurred in 18 (10/34 under 6 months of age, 8/21 older than 6 months). Serum sulfated lithocholate concentrations were a more sensitive indicator of cholestasis than either direct bilirubin or aminotransferases. The serum lithocholate concentrations in parenteral nutrition-associated liver disease were similar to those seen in patients with known cholestasis.
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