Polymorphonuclear leukocyte (PMN) adherence to nylon was assayed in blood obtained from 10 malnourished patients before and during therapy with total parenteral nutrition (TPN). All patients demonstrated minimal to moderate loss of visceral and somatic protein. Adherence of PMN was unaltered by malnutrition or during the 4 wk of TPN in spite of hyperglycemia, which required insulin therapy in 4 patients. There was no correlation of blood sugar levels and PMN adherence.
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References
1.
Phair JP, Reising KS, Metzger E.: Bacteremic infection and malnutrition in patient with solid tumors: investigation of host defense mechanism. Cancer45:2702-2706, 1980
2.
Phair J., Vasquez R., Craig, R., et al: Malnutrition. Cancer and Polymorphonuclear leukocyte function. Current Chemotherapy and Infectious Disease. Proceedings 11th International Congress of Chemotherapy. American Society of Microbiology, Washington, D.C., 1980, pp 1744-1746
3.
MacGregor RR , Macaraks EJ, Kefalides NA: Comparative adherence of granulocytes to endothelial monolayers and nylon fibers. J Clin Invest61:697-702, 1978
4.
Grant L.: The sticking and emigration of white blood cells in inflammation. IN The Inflammatory Process, 2nd ed, vol II, ed. B Zweifach , L Grant, RT McCluskey (eds). New York/London , Academic Press, 1973, p 205
5.
Bagdade JD, Stewart M., Walters E.: Impaired granulocyte adherence. Diabetes27:677-681, 1978
6.
Ryan JA: Complications of total parenteral nutrition. IN Total Parenteral Nutrition. JE Fischer (ed). Boston, Little, Brown & Co., 1976 , p 55
7.
Phair JP, Kauffman CA, Bjornson A., et al: Host defenses in the aged: evaluation of components of the inflammatory and immune responses. J Infect Dis138:67-73, 1978
8.
McGillen J., Phair JP: Adherence, augmented adherence, and aggregation of polymorphonuclear leukocytes . J Infect Dis139:69-73, 1979
Law DK, Dudrick SJ, Abdoub NI: Immunocompetence of patients with protein-caloric malnutrition. The effects of nutritional repletion. Ann Intern Med79:545-550, 1973
11.
Christou NV , Meakins JL: Neutrophil function in anergic surgical patients . Ann Surg190:557-564, 1979
