The plasma amino acids of 17 patients were studied before and during total parenteral nutrition (TPN). The amino acid (AA) pattern changed similarly for all patients. The AA concentration changes relative to preinfusion (PAER) were the most informative index of change. Two groups of AA were defined, the “branched chain” group (five amino acids) and the “hepatic” group (four amino acids) based on the correlation of PAER values. Comparison of PAER values with the ratio of AA intake to requirement indicated that the requirements of the sick patients were more similar to those of children than those of healthy adults.
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References
1.
Young VR, Hussein MA, Murray E et al: Plasma tryptophan response curve and its relation to tryptophan requirements in young adult men. J Nutr101:45–60, 1971.
2.
Anderson GH, Patel DG, Jeejeebhoy KN: Design and evaluation by nitrogen balance and blood aminograms of an amino acid mixture for total parenteral nutrition of adults with gastrointestinal disease.J Clin Invest53:904–912, 1974.
3.
Longenecker JB, Hause NL: Relationship between plasma amino acids and composition of ingested protein.Arch Biochem Biophys84:46–59, 1959.
4.
Long CL, Zikria BA, Kinney JM et al: Comparison of fibrin hydro-lyzate with synthetic amino acid mixture in parenteral nutrition. Am J Clin Nutr27:163–174, 1974.
5.
Dolif D, Jurgen P: The utilization of non essential amino acids in parenteral nutrition.Med U Emahrung11:67–71, 1970.
6.
Wells FE, Smits BJS: Utilization and metabolic effects of a solution of amino acids, sorbitol and ethanol in parenteral nutrition.Am J Clin Nutr31:442–450, 1978.
7.
Munro HN: Basic concepts in the use of amino acids and protein hydrolyzates for parenteral nutrition. IN Council on Foods and Nutrition, Symposium on Total Parenteral Nutrition, American Medical Association, 1972., p 7.
8.
Adibi SA: Metabolism of branched chain amino acids in altered nutrition.Metabolism25:1287–1302, 1976.
