Role of Neurogenic Stimuli in Mediating the Endocrine-Metabolic Response to Surgery

1. Hume, DM , Egdahl RH : The importance of the brain in the endocrine response to injury. Ann Surg 150:697–712, 1959.

2. Wilmore DW , Long JM , Mason AD, et al : Stress in surgical patients as a neurophysiologic reflex response. Surg Gynecol Obstet 142: 257–269, 1976.

3. Engquist A , Brandt MR , Fernandes A , Kehlet, H : The blocking effect of epidural analgesia on the adrenocortical and hyperglycemic responses to surgery. Acta Anaesthesiol Scand 21:330–335, 1977.

4. Brandt MR , Ølgaard K , Kehlet H : Epidural analgesia inhibits renin and aldosterone response to surgery. Acta Anaesthesiol Scand 23: 267–272, 1979.

5. Brandt MR , Kehlet H , Faber O, et al : C-peptide and insulin during blockade of the hyperglycemic response to surgery by epidural analgesia. Clin Endocrinol 6:167–170, 1977.

6. Brandt MR , Kehlet H , Binder C, et al : Effect of epidural analgesia on the glucoregulatory endocrine response to surgery. Clin Endocrinol 5:107–114, 1976.

7. Hagen C, Brandt MR, Kehlet H: Prolactin, LH, FSH, GH and cortisol response to surgery and the effect of epidural analgesia. Acta Endocrinol (Kbh), in press

8. Brandt MR , Kehlet H , Skovsted L, et al : Rapid decrease in plasma-triiodothyronine during surgery and epidural analgesia independent. of afferent neurogenic stimuli and of Cortisol. Lancet 2:1333–1336, 1976.

9. Engquist A, Fog-Moller F, Christiansen C, Thode J, Vester-Andersen T, Nistrup Madsen S: Influence of epidural analgesia on the catecholamine and cyclic AMP responses to surgery. Acta Anaesthesiol Scand, in press

10. Kehlet H , Brandt MR , Prange Hansen A , Alberti KGMM : Effect of epidural analgesia on metabolic profiles during and after surgery. J Surg 66:543–546, 1979.

11. Nistrup Madsen S , Brandt MR , Engquist A , Badawi I, Kehlet H : Inhibition of plasma cAMP, glucose and cortisol response to surgery by epidural analgesia. Br J Surg 64:669–671, 1977.

12. Brandt MR , Fernandes A , Mordhorst R, et al : Epidural analgesia improves postoperative nitrogen balance. Br Med J I: 1106–1108, 1978.

13. Rem J , Brandt MR , Kehlet H : Prevention of postoperative lymphopenia and granulocytosis by epidural analgesia. Lancet 1:283–285, 1980.

14. Rem J, Brandt MR, Kehlet H: Influence of epidural analgesia on postoperative liver enzyme pattern and creatine kinase. Submitted for publication

15. Lush D , Thorpe JN , Richardson DJ , Bowen DJ : The effect of epidural analgesia on the adrenocortical response to surgery. Br J Anaesth 44:1169–1172, 1972.

16. Bromage PR , Shibata HR , Willoughby HW : Influence of prolonged epidural blockade on blood sugar and cortisol responses to operations upon the upper part of abdomen and the thorax. Surg Gynecol Obstet 132:1051–1056, 1971.

17. Newsome HH , Rose JC : The response of human adrenocorticotropic, hormone and growth hormone to surgical stress. J Clin Endocrinol Metabol 33:481–487, 1971.

18. Gordon NH , Scott DB , Percy Robb IW : Modification of plasma corticosteroid concentrations during and after surgery by epidural blockade. Br Med J 1:581–583, 1973.

19. Cosgrove DO , Jenkins JS : The effects of epidural anaesthesia on the pituitary-adrenal response to surgery. Clin Sci Mol Med 46: 403–407, 1974.

20. Allison SP , Tomlin PS , Chamberlain MJ : Some effects of anaesthesia and surgery on carbohydrate and fat metabolism. Br J Anaesth 41:588–593, 1969.

21. Porte D Jr , Robertson RP : Control of insulin secretion by catecholamines, stress and the sympathetic nervous system. Fed Proc 32:1792–1796, 1973.

22. Kehlet H , Klauber PV , Weeke J : Thyrotropin, free and total triiodothyronine, and thyroxine in serum during surgery. Clin Endocrinol 10:131–136, 1979.

23. Rem J, Feddersen C, Brandt MR, Kehlet H: Postoperative changes in coagulation and fibrinolysis independent of neurogenic stimuli and of adrenal hormones. Submitted for publication

24. Oyama T , Takazawa T : Effects of halothane anaesthesia and surgery on human growth hormone and insulin levels in plasma. Br J Anaesth 43:573–580, 1971.

25. Von Werder K , Stevens WC , Cromwell TH, et al : Adrenal function during long-term anaesthesia in man. Proc Soc Exptl Biol Med 135: 854–858, 1970.

26. Nistrup Madsen S , Engquist A , Badawi I , Kehlet H : Cyclic AMP, glucose and Cortisol in plasma during surgery. Horm Metab Res 8: 483–485, 1976.

27. Renck H : The elderly patient after anaesthesia and surgery. Acta Anaesthesiol Scand (Suppl 34), 1969.

28. Pflug AE , Murphy TM , Butler SH, et al : The effects of postoperative peridural analgesia on pulmonary therapy and pulmonary complications. Anesthesiology 41:8–17, 1974.

29. Maclean LO , Meakins JL , Taguchi K , Duignan JP , Dhillon KS , Gordon J : Host resistance in sepsis and trauma. Ann Surg 182:207–217, 1975.

30. Meakins JL , Pietsch JB , Bubenick O , Kelly R , Rode H , Gordon J , Maclean LD : Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg 186:241–250, 1977.

31. Kehlet H , Thomsen M , Kjær M , Platz P : Postoperative depression of in vitro lymphocyte transformation to microbial antigens. Br J Surg 64:890–893, 1977.