Still a Place for Metoclopramide as a Prokinetic Drug in Critically Ill Patients?

FDA requires boxed warning and risk mitigation strategy for metoclopramide-containing drugs. FDA news release. February 26, 2009. http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm149533.htm

Metoclopramide: strong warnings on risk of abnormal muscle movements. Health Canada. July 20, 2011. http://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2011/13627a-eng.php

European Medicines Agency. European Medicines Agency recommends changes to the use of metoclopramide. London: Science Medicines Health, 2013. EMA/443003/2013.

European Medicines Agency. Assessment report for metoclopramide-containing medicines. 2013. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/referrals/Metoclopramide-containing_medicines/human_referral_000349.jsp&mid=WC0b01ac05805c516f

Shaffer D Butterfield M Pamer C Mackey AC . Tardive dyskinesia risks and metoclopramide use before and after U.S. market withdrawal of cisapride. J Am Pharm Assoc. 2004;44:661-665.

Rao AS Camilleri M . Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010;31:11-19.

Bateman DN Rawlins MD Simpson JM . Extrapyramidal reactions with metoclopramide. Br Med J (Clin Res Ed.). 1985;291:930-932.

Parlak I Atilla R Cicek M . Rate of metoclopramide infusion affects the severity and incidence of akathisia. Emerg Med J. 2005;22:621-624.

Grant K Thomas R . Prokinetic drugs in the intensive care unit: reviewing the evidence. JICS. 2009;10:34-37.

Ritz MA Fraser R Tam W Dent J . Impacts and patterns of disturbed gastrointestinal function in critically ill patients. Am J Gastroenterol. 2000;95:3044-3052.

Deane AM Fraser RJ Chapman MJ . Prokinetic drugs for feed intolerance in critical illness: current and potential therapies. Crit Care Resusc. 2009;11:132-143.

Gungabissoon U Hacquoil K Bains C . Prevalence, risk factors, clinical consequences, and treatment of enteral feed intolerance during critical illness [published online March 17, 2014]. JPEN J Parenter Enteral Nutr.

Nguyen NQ Chapman M Fraser RJ Bryant LK Burgstad C Holloway RH . Prokinetic therapy for feed intolerance in critical illness: one drug or two? Crit Care Med. 2007;35:2561-2567.

Aronoff GR , ed. Drug Prescribing in Renal Failure. Dosing Guidelines for Adults and Children. 5th ed. Philadelphia, PA: American College of Physicians; 2007.

European Medicines Agency. Summary of product characteristics: Primperan. London: Science Medicines Health, 2014.

American Hospital Formulary Service. AHFS Drug Information 2013. Bethesda, MD: American Society of Health-System Pharmacists; 2013.

Nguyen NQ Chapman MJ Fraser RJ Bryant LK Holloway RH . Erythromycin is more effective than metoclopramide in the treatment of feed intolerance in critical illness. Crit Care Med. 2007;35:483-489.

Ritz MA Chapman MJ Fraser RJ . Erythromycin dose of 70 mg accelerates gastric emptying as effectively as 200 mg in the critically ill. Intensive Care Med. 2005;31:949-954.

Levin F Erdholm T Schmidt PT . Ghrelin stimulates gastric emptying and hunger in normal-weight humans. J Clin Endocrinol Metab. 2006;91:3296-3302.

Murray CD Martin NM Patterson M . Ghrelin enhances gastric emptying in diabetic gastroparesis: a double-blind, placebo-controlled, crossover study. Gut. 2005;54:1693-1698.

Nagaya N Itoh T Murakami S . Treatment of cachexia with ghrelin in patients with COPD. Chest. 2005;128:1187-1193.

Nagaya N Moriya J Yasumura Y . Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation. 2004;110:3674-3679.

Chapman M Fraser R Nguyen N . The effect of GSK962040, a selective motilin agonist, on gastric emptying in critically ill patients with enteral feed intolerance (MOT112571). Crit Care Med. 2011;39(suppl):Abstract 700.

FDA Announces Discontinued Marketing of GI drug, Zelnorm, for safety reasons. 2007. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108879.htm

Beattie DT Armstrong SR Vickery RG . The pharmacology of TD-8954, a potent and selective 5-HT₄ receptor agonist with gastrointestinal prokinetic properties. Front Pharmacol. 2011;2:1-13.

Yavagal DR Karnad DR Oak JL . Metoclopramide for preventing pneumonia in critically ill patients receiving enteral tube feeding: a randomized controlled trial. Crit Care Med. 2000;28:1408-1411.