Invasive aspergillosis is usually seen in immunocompromised individuals. We report the case of a 56-year-old immunocompetent housewife with Aspergillus niger invading the ethamoid and sphenoid sinuses and extending to the anterior cranial fossa. A. niger grew on three occasions (from the biopsy, mass and duramater). In spite of medial maxillectomy and ethmoidectomy followed by craniofacial resection and antifungal drugs (amphotericin B) the patient died on tenth post-operative day.
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