Neurostimulation of the upper airway muscles (accessory muscles of respiration) was accomplished in anesthetized dogs and sleeping humans by electrical stimulation of the hypoglossal nerves. Such stimulations relieved partial airway obstructions in dogs. They also aborted (shortened) obstructive sleep apnea events in humans who suffer with obstructive sleep apnea syndrome. In one subject, stimulations delivered in advance of apneic events (by automatic cycling) prevented apneas. Neurostimulation for obstructive sleep apnea may be an important concept for future research and development.
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References
1.
MikiH, HidaW, ShindohC, Effects of electrical stimulation of the genioglossus on upper airway resistance in anesthetized dogs. American Review of Respiratory Disease1989; 140:1279–84.
2.
StrohlKP, FoukeJM. Dilating forces on the upper airway of anesthetized dogs. Journal of Applied Physiology1985; 58:452–8.
3.
FoulkeJM, WolinAD, van LunterenE, Demonstration that pharyngeal muscle activation can result in an airway dilating force. Acta Biol Med Exp1986; 11:291–9.
4.
MikiH.A new treatment for obstructive sleep apnea syndrome by electrical stimulation of submental region. Tohoka Journal of Experimental Medicine1988; 154:91.
5.
BroniatowskiM.Bionic larynx: electronic control of the reimplanted organ in the dog. Laryngoscope1988; 98:1107–15.
6.
FairbanksDW. Apnea-activated tongue stimulation for obstructive sleep apnea. Otolaryngology–Head and Neck Surgery1990; 103:190.
7.
HylandRH, HutcheonMA, PerlA, Upper airway occlusion induced by diaphragm pacing for primary alveolar hypoventilation: implications for pathogenesis of obstructive sleep apnea. American Review Respiratory Disease1981; 124:180–5.
