Loracarbef (LY 163892), a β-lactam antibiotic (carbacephem), was compared with amoxicillin/ clavulanate potassium in a 10-day, single-blind, randomized parallel trial in the treatment of acute bacterial maxillary sinusitis. Based on posttherapy aspirate and culture, there was a 95.2% bacteriologic cure rate in patients receiving loracarbef (400 mg twice daily) and an 86.7% cure rate in patients receiving amoxicillin/clavulanate (500/125 mg three times daily) (p = 0.359). Loracarbef was comparable in efficacy to amoxicillin/clavulanate with a more desirable safety profile.
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References
1.
GwaltneyJ.M.Jr.Sinusitis, in MandellG.L., DouglasR.G.Jr., MennettJ.E., eds: Principles and practice of infectious diseases. 3rd ed. New York, Churchill Livingstone, 1990: 510–14.
2.
WaldE.R., ByersC., GuerraN.Subacute sinusitis in children. J Pediatr1989; 115: 28–32.
3.
BlaszczakL.C., BrownR.F., CookG.K.Comparative reactivity of 1-carba-1-dethiacephalosporins with cephalosporins. J Med Chem1990; 33: 1656–62.
4.
CrowellT.A., HallidayB.D., McDonaldJHIII3-Sulfonyl-1-carba-1-dethiacephems. J Med Chem1989; 32: 2436–42.
5.
KnappC.C., WashingtonJAIIIn vitro activities of LY 163892, cefaclor and cefuroxime. Antimicrob Agents Chemother1988; 32: 131–3.
6.
SheltonS., NelsonJ.D.In vitro susceptibilities of common pediatric pathogens to LY163892. Antimicrob Agents Chemother1988; 32: 268–70.
7.
WaldE.R., ChiponisD., Ledesma-MedinaJ.Comparative effectiveness of amoxicillin and amoxicillin-clavulanate potassium in acute paranasal sinus infections in children: a double-blind, placebo-controlled trial. Pediatrics1986; 77: 795–800.
8.
JorgensenJ.H., ReddingJ.S., MaherL.A.Influence of storage and susceptibility test conditions on stability and activity of LY163892 and four other cephalosporins. Antimicrob Agents Chemother1988; 32: 1477–80.
9.
EisenS.A., MillerD.K., WoodwardR.S.The effect of prescribed daily dose frequency on patient medication compliance. Arch Intern Med1990; 150: 1881–4.
10.
JonesR.N., BarryA.L.Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892. Eur J Clin Microbiol1987; 6: 570–1.
