A 26-year-old woman presented with recurrent Kikuchi disease 7 years after her initial episode. Computed tomography (CT) and ultrasonography demonstrated enlarged lymph nodes with extensive necrosis at the same site as the initial episode. Cytologic and histologic examinations were not conclusive. CT performed 1 month later demonstrated a complete resolution of the lymphadenopathy, which confirmed the diagnosis of recurrent Kikuchi disease. Care must be taken to avoid misdiagnosis of recurrent Kikuchi disease as tuberculous lymphadenitis.
References
1.
FelgarRE, FurthEE, WasikMA, Histiocytic necrotizing lymphadenitis (Kikuchi's disease): In situ end-labeling, immunohistochemical, and serologic evidence supporting cytotoxic lymphocyte-mediated apoptotic cell death. Mod Pathol1997;10(3):231–41.
2.
DominguezDC, TorresML, AntonyS.Is human herpesvirus 6 linked to Kikuchi-Fujimoto disease? The importance of consistent molecular and serologic analysis. South Med J2003;96(3):226–33.
3.
HudnallSD.Kikuchi-Fujimoto disease. Is Epstein-Barr virus the culprit?Am J Clin Pathol2000;113(6):761–4.
4.
FulcherAS.Cervical lymphadenopathy due to Kikuchi disease: US and CT appearance. J Comput Assist Tomogr1993;17(1):131–3.
5.
KimTA, LupetinAR, GrahamC.CT appearance of Kikuchi-Fujimoto disease. Clin Imaging1995;19(1):1–3.
6.
KwonSY, KimTK, KimYS, CT findings in Kikuchi disease: Analysis of 96 cases. AJNR Am J Neuroradiol2004;25(6): 1099–1102.
BlewittRW, KumarSN, AbrahamJS.Recurrence of Kikuchi's lymphadenitis after 12 years. J Clin Pathol2000;53(2):157–8.
9.
Alijotas-ReigJ, Casellas-CaroM, Ferrer-OliverasR, Recurrent Kikuchi-Fujimoto disease during pregnancy: Report of case evolving into systemic lupus erythematosus and review of published work. J Obstet Gynaecol Res2008;34(4 Pt 2):595–8.
MoonWK, HanMH, ChangKH, CT and MR imaging of head and neck tuberculosis. Radiographics1997;17(2):391–402.
12.
ChengCY, ShengWH, LoYC, Clinical presentations, laboratory results and outcomes of patients with Kikuchi's disease: Emphasis on the association between recurrent Kikuchi's disease and autoimmune diseases. J Microbiol Immunol Infect2010;43(5):366–71.
13.
SongJY, LeeJ, ParkDW, Clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease. Int J Infect Dis2009;13(3):322–6.
