Granulocytic sarcoma of the nasal cavity is exceedingly rare. We describe the case of a 55-year-old man who presented with an intranasal mass that was later diagnosed as a granulocytic sarcoma. The mass was treated with rapid initiation of chemotherapy, which produced a substantial decrease in tumor bulk. Granulocytic sarcoma is often mistaken for lymphoma or other poorly differentiated malignancies, and the correct diagnosis requires a high index of clinical suspicion.
References
1.
NeimanR.S., BarcosM., BerardC.Granulocytic sarcoma: A clinicopathologic study of 61 biopsied cases. Cancer1981; 48(6): 1426–37.
LeeS.S., KimH.K., ChoiS.C., LeeJ.I.Granulocytic sarcoma occurring in the maxillary gingiva demonstrated by magnetic resonance imaging. Oral Surg Oral Med Oral Pathol Oral Radiol Endod2001; 92(6): 689–93.
5.
GoteriG., AscaniG., MessiM.Myeloid sarcoma of the maxillary bone. J Oral Pathol Med2006; 35(4): 254–6.
6.
SoodB.R., SharmaB., KumarS.Facial palsy as the first presentation of acute myeloid leukemia. Am J Hematol2003; 74(3): 200–1.
7.
DikbasO., IsikM., PurnakT.Isolated granulocytic sarcoma of the head and neck preceding acute myeloid leukemia. Am J Hematol2004; 76(1): 95–6.
8.
CankayaH., UgrasS., DilekI.Head and neck granulocytic sarcoma with acute myeloid leukemia: Three rare cases. Ear Nose Throat J2001; 80(4): 224–6, 28–9.
9.
ThomasR.F., KerrJ.T., EustermanV.D.Granulocytic sarcoma presenting with facial nerve paralysis and otalgia [abstract]. Otolaryngol Head Neck Surg2005; 133(2 Suppl): 241.
10.
GokcanM.K., BatikhanH., CalgunarM., TataragasiA.I.Unilateral hearing loss as a presenting manifestation of granulocytic sarcoma (chloroma). Otol Neurotol2006; 27(1): 106–9.
11.
BassichisB., McClayJ., WiatrakB.Chloroma of the masseteric muscle. Int J Pediatr Otorhinolaryngol2000; 53(1): 57–61.
12.
PradesJ.M., AlaaniA., MosnierJ.F.Granulocytic sarcoma of the nasal cavity. Rhinology2002; 40(3): 159–61.
13.
FerriE., MinottoC., IannielloF.Maxillo-ethmoidal chloroma in acute myelogenous leukemia: Case report. Acta Otorhinolaryngol Ital2005; 25(3): 195–9.
14.
BarnesL., EvesonJ.W., ReichartP., SidranskyD., eds. Pathology and Genetics: Head and Neck Tumours. KleihuesP., SobinL.H., series eds. World Health Organization Classification of Tumours.Lyon, France: IARC Press, 2005.
15.
DulguerovP., AllalA.S., CalcaterraT.C.Esthesioneuroblastoma: A meta-analysis and review. Lancet Oncol2001; 2(11): 683–90.
16.
MenasceL.P., BanerjeeS.S., BeckettE., HarrisM.Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: A study of 26 cases. Histopathology1999; 34(5): 391–8.
17.
SuhY.K., ShinH.J.Fine-needle aspiration biopsy of granulocytic sarcoma: A clinicopathologic study of 27 cases. Cancer2000; 90(6): 364–72.
18.
ChooP.H., ArainS.A., CarolanJ.A.Extramedullary myeloid leukemia: The value of cytogenetic analysis in pediatric orbital tumors. Ophthal Plast Reconstr Surg2006; 22(2): 143–5.
19.
ByrdJ.C., EdenfieldW.J., ShieldsD.J., DawsonN.A.Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: A clinical review. J Clin Oncol1995; 13(7): 1800–16.
20.
YamauchiK., YasudaM.Comparison in treatments of nonleukemic granulocytic sarcoma: Report of two cases and a review of 72 cases in the literature. Cancer2002; 94(6): 1739–46.
21.
ImrieK.R., KovacsM.J., SelbyD.Isolated chloroma: The effect of early antileukemic therapy. Ann Intern Med1995; 123(5): 351–3.
22.
MartinelliG., OttavianiE., TestoniN.Molecular analysis of granulocytic sarcoma: A single center experience. Haemotologica1999; 84(4): 380–2.
