Impact of Biofilms on the Treatment of Otitis

Costerton JW , Stewart PS , Greenberg EP . Bacterial biofilms: A common cause of persistent infections. Science 1999;284(5418):1318–22.

Buret A , Ward KH , Olson ME , Costerton JW . An in vivo model to study the pathobiology of infectious biofilms on biomaterial surfaces. J Biomed Mater Res 1991;25(7):865–74.

Gilbert P , Collier PJ , Brown MR . Influence of growth rate on susceptibility to antimicrobial agents: Biofilms, cell cycle, dormancy, and stringent response. Antimicrob Agents Chemother 1990;34(10):1865–8.

Hoyle BD , Jass J , Costerton JW . The biofilm glycocalyx as a resistance factor. J Antimicrob Chemother 1990;26(1):1–5.

Olson ME , Ceri H , Morck DW , Biofilm bacteria: Formation and comparative susceptibility to antibiotics. Can J Vet Res 2002;66(2):86–92.

Desrosiers M , Bendouah Z , Barbeau J. Effectiveness of topical antibiotics on Staphylococcus aureus biofilm in vitro. Am J Rhinol 2007;21(2):149–53.

Chiu AG , Antunes MB , Palmer JN , Cohen NA . Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms. J Antimicrob Chemother 2007;59(6):1130–4.

Vaudaux P , Francois P , Berger-Bächi B , Lew DP . In vivo emergence of subpopulations expressing teicoplanin or vancomycin resistance phenotypes in aglycopeptide-susceptible, methicillin-resistant strain of Staphylococcus aureus. J Antimicrob Chemother 2001;47(2):163–70.

Chen HY , Yuan M , Livermore DM . Mechanisms of resistance to beta-lactam antibiotics amongst Pseudomonas aeruginosa isolates collected in the UK in 1993. J Med Microbiol 1995;43(4):300–9.

Brooun A , Liu S , Lewis K. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 2000;44(3):640–6.

Giwercman B , Jensen ET , Høiby N , Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm. Antimicrob Agents Chemother 1991;35(5):1008–10.

Peron DL , Kitamura K , Carniol PJ , Schuknecht HF . Clinical and experimental results with focused ultrasound. Laryngoscope 1983;93(9):1217–21.

Morizono T , Sikora MA . The ototoxicity of topically applied povidone-iodine preparations. Arch Otolaryngol 1982;108(4):210–13.

Post JC . Direct evidence of bacterial biofilms in otitis media. Laryngoscope 2001;111(12):2083–94.

Walker TS , Tomlin KL , Worthen GS , Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils. Infect Immun 2005;73(6):3693–3701.

Jensen PØ , Bjarnsholt T , Phipps R , Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology 2007;153(Pt 5):1329–38.

Alper CM , Dohar JE , Gulhan M , Treatment of chronic suppurative otitis media with topical tobramycin and dexamethasone. Arch Otolaryngol Head Neck Surg 2000;126(2):165–73.

Roland PS , Kreisler LS , Reese B , Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. Pediatrics 2004;113(1 Pt 1):e40–6.

Roland PS , Dohar JE , Lanier BJ , ; CIPRODEX AOMT Study Group. Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. Otolaryngol Head Neck Surg 2004:130(6):736–41.

Roland PS , Anon JB , Moe RD , Topical ciprofloxacin/dexamethasone is superior to ciprofloxacin alone in pediatric patients with acute otitis media and otorrhea through tympanostomy tubes. Laryngoscope 2003;113(12):2116–22.

van Balen FA , Smit WM , Zuithoff NP , Verheij TJ . Clinical efficacy of three common treatments in acute otitis externa in primary care: Randomised controlled trial. BMJ 2003;327(7425):1201–5.

Tsikoudas A , Jasser P , England RJ . Are topical antibiotics necessary in the management of otitis externa? Clin Otolaryngol Allied Sci 2002;27(4):260–2.

Anwar H , Strap JL , Chen K , Costerton J W. Dynamic interactions of biofilms of mucoid Pseudomonas aeruginosa with tobramycin and piperacillin. Antimicrob Agents Chemother 1992;36(6):1208–14.

Malaty J , Antonelli PJ . Effect of body fluids on tympanostomy tube biofilm formation with Pseudomonas aeruginosa. Submitted for presentation at the Southern Section meeting of the Triological Society; January 2008; Naples, Fla.

Kinnari TJ , Salonen EM , Jero J. Durability of the binding inhibition of albumin coating on tympanostomy tubes. Int J Pediatr Otorhinolaryngol 2003;67(2):157–64.

Kinnari TJ , Rihkanen H , Laine T , Albumin-coated tympanostomy tubes: Prospective, double-blind clinical study. Laryngoscope 2004;114(11):2038–43.

Berry JA , Biedlingmaier JF , Whelan PJ . In vitro resistance to bacterial biofilm formation on coated fluoroplastic tympanostomy tubes. Otolaryngol Head Neck Surg 2000;123(3):246–51.

Loeffler KA , Johnson TA , Burne RA , Antonelli PJ . Biofilm formation in an in vitro model of cochlear implants with removable magnets. Otolaryngol Head Neck Surg 2007;136(4):583–8.

Johnson TA , Loeffler TA , Burne RA , Biofilm formation in cochlear implants with cochlear drug delivery channels in an in vitro model. Otolaryngol Head Neck Surg 2007;136(4):577–82.

Pasmore M , Todd P , Smith S , Effects of ultrafiltration membrane surface properties on Pseudomonas aeruginosa biofilm initiation for the purpose of reducing biofouling. Journal of Membrane Science 2001;194(1):15–32.

Scheuerman TR , Camper AK , Hamilton MA . Effects of substratum topography on bacterial adhesion. J Colloid Interface Sci 1998;208(1):23–33.

Chung K , Schumacher J , Sampson E , Engineered substratum topography to disrupt bacterial biofilm formation. Presented at the 32nd annual meeting of the Society for Biomaterials; April 18–21, 2007; Chicago.

Bothwell MR , Smith AL , Phillips T. Recalcitrant otorrhea due to Pseudomonas biofilm. Otolaryngol Head Neck Surg 2003;129(5):599–601.

Tatar EC , Unal FO , Tatar I , Investigation of surface changes in different types of ventilation tubes using scanning electron microscopy and correlation of findings with clinical follow-up. Int J Pediatr Otorhinolaryngol 2006;70(3):411–17.

Mehta AJ , Lee JC , Stevens GR , Antonelli PJ . Opening plugged tympanostomy tubes: Effect of biofilm formation. Otolaryngol Head Neck Surg 2006;134(1):121–5.