Safety and Efficacy of Topical Steroids with and without Topical Antibiotics

Parnes LS , Sun AH , Freeman DJ . Corticosteroid pharmacokinetics in the inner ear fluids: An animal study followed by clinical application. Laryngoscope 1999;109(7 Pt 2):1–17.

Chandrasekhar SS , Rubinstein RY , Kwartler JA , Dexamethasone pharmacokinetics in the inner ear: Comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg 2000;122:521–8.

Sahni RS , Paparella MM , Schachern PA , Thickness of the human round window membrane in different forms of otitis media. Arch Otolaryngol Head Neck Surg 1987;113:630–4.

Ghubash R , Marsella R , Kunkle G. Evaluation of adrenal function in small-breed dogs receiving otic glucocorticoids. Vet Dermatol 2004;15:363–8.

Moriello KA , Fehrer-Sawyer SL , Meyer DJ , Feder B. Adrenocortical suppression associated with topical otic administration of glucocorticoids in dogs. J Am Vet Med Assoc 1988;193:329–31.

Roland PS . Clinical ototoxicity of topical antibiotic drops. Otolaryngol Head Neck Surg 1994;110:598–602.

Spandow O , Hellstrom S , Schmidt SH . Hydrocortisone delay of tissue repair of experimental tympanic membrane perforations. Ann Otol Rhinol Laryngol 1990;99:647–53.

Spandow O , Hellstrom S , Anniko M. Impaired hearing following instillation of hydrocortisone into the middle ear. Preliminary report from an animal study. Acta Otolaryngol Suppl 1988;455:90–3.

Monkhouse WS , Moran P , Freedman A. The histological effects on the guinea pig external ear of several constituents of commonly used aural preparations. Clin Otolaryngol 1988;13:121–31.

Parker FL , James GW . The effect of various topical antibiotic and antibacterial agents on the middle and inner ear of the guinea-pig. J Pharm Pharmacol 1978;30:236–9.

Shirwany NA , Seidman MD , Tang W. Effect of transtympanic injection of steroids on cochlear blood flow, auditory sensitivity, and histology in the guinea pig. Am J Otol 1998;19:230–5.

Mattsson C , Stierna P , Hellstrom S. Treatment with dexamethasone arrests the development of myringosclerosis after myringotomy. Am J Otol 2000;21:804–8.

Nordang L , Linder B , Anniko M. Morphologic changes in round window membrane after topical hydrocortisone and dexamethasone treatment. Otol Neurotol 2003;24:339–43.

Kaplan DM , Hehar SS , Bance ML , Rutka JA . Intentional ablation of vestibular function using commercially available topical gentamicin-betamethasone eardrops in patients with Meniere's disease: Further evidence for topical eardrop ototoxicity. Laryngoscope 2002;112:689–95.

Spandow O , Hellstrom S. Animal model for persistent tympanic membrane perforations. Ann Otol Rhinol Laryngol 1993;102:467–72.

Magnuson K , Hermansson A , Hellstrom S. Healing of tympanic membrane after myringotomy during Streptococcus pneumoniae otitis media. An otomicroscopic and histologic study in the rat. Ann Otol Rhinol Laryngol 1996;105:397–404.

Tsikoudas A , Jasser P , England RJ . Are topical antibiotics necessary in the management of otitis externa? Clin Otolaryngol 2002;27:260–2.

Spektor Z , Jasek MC , Jasheway D , Pharmacokinetics of topical CiproDex otic suspension in pediatric and adolescent patients after tympanostomy tube surgery. Presented at the annual meeting of the American Society of Pediatric Otolaryngology; May 2–3, 2004; Phoenix.

Tartaglione TA , Raffalovich AC , Poynor WJ , Pharmacokinetics and tolerance of ciprofloxacin after sequential increasing oral doses. Antimicrob Agents Chemother 1986;29:62–6.

Doyle KJ , Bauch C , Battista R , Intratympanic steroid treatment: A review. Otol Neurotol 2004;25:1034–9.

Takeuchi N , Anniko M. Dexamethasone modifies the effect of Pseudomonas aeruginosa exotoxin A on hearing. Acta Otolaryngol 2000;120:363–8.

Park SK , Choi D , Russell P , Protective effect of corticosteroid against the cytotoxicity of aminoglycoside otic drops on isolated cochlear outer hair cells. Laryngoscope 2004;114:768–71.

Russell PT , Church CA , Jinn TH , Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells. Acta Otolaryngol 200;121:135–9.

Shefelbine SE , Young LJ , Antonelli PJ . Mitigation of hearing loss from semicircular canal transection in Pseudomonas otitis media with ciprofloxacin-dexamethasone irrigation. Otol Neurotol [in press].

Chan YM , Adams DA , Kerr AG . Syphilitic labyrinthitis—An update. J Laryngol Otol 1995;109:719–25.

Rappaport JM , Bhatt SM , Burkard RF , Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. J Infect Dis 1999;179:264–8.

Kawana M , Kawana C , Giebink GS . Penicillin treatment accelerates middle ear inflammation in experimental pneumococcal otitis media. Infect Immun 1992;60:1908–12.

Sato K , Quartey MK , Liebeler CL , Giebink GS . Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation. Antimicrob Agents Chemother 1995;39:1896–8.

Roland PS , Anon JB , Moe RD , Topical ciprofloxacin/dexamethasone is superior to ciprofloxacin alone in pediatric patients with acute otitis media and otorrhea through tympanostomy tubes. Laryngoscope 2003;113:2116–22.

Roland PS , Kreisler LS , Reese B , Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. Pediatrics 2004;113(1 Pt 1):e40–6.

Roland PS , Dohar JE , Lanier BJ , Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. Otolaryngol Head Neck Surg 2004;130:736–41.

Alper CM , Dohar JE , Gulhan M , Treatment of chronic suppurative otitis media with topical tobramycin and dexamethasone. Arch Otolaryngol Head Neck Surg 2000;126:165–73.

Gananca MM , Albernaz PL . Topical use of tobramycin, gentamycin, neomycin + polymyxin B, dexamethasone, and lidocaine in the treatment of otitis. In: Myers E , ed. New Dimensions in ORL and Head and Neck Surgery. (Proceedings of the XIIIth World Congress of Otorhinolaryngology; May 26–31, 1985; Miami Beach, Fla.) New York: Elsevier, 1985:237–8.

Kaygusuz I , Karlidag T , Gok U , [Efficacy of topical ciprofloxacin and tobramycin in combination with dexamethasone in the treatment of chronic suppurative otitis media]. Kulak Burun Bogaz Ihtis Derg 2002;9:106–11.

Park SN , Yeo SW . Effects of antibiotics and steroid on middle ear mucosa in rats with experimental acute otitis media. Acta Otolaryngol 2001;121:808–12.

Emgard P , Hellstrom S. Agroup III steroid solution without antibiotic components: An effective cure for external otitis. J Laryngol Otol 2005;119:342–7.