Control of the symptoms of vertigo and motion sickness requires consideration of the neurophysiology of areas both intrinsic and extrinsic to the vestibular system proper. We review the essential anatomy and physiology of the vestibular system and the associated vomiting reflex.
References
1.
CramptonGH, ed. Motion and Space Sickness. Boca Raton, Fla.: CRC Press, 1990.
2.
RaymondJ, NieoullonA, DememesD, SansA.Evidence for glutamate as a neurotransmitter in the cat vestibular nerve: Radioautographic and biochemical studies. Exp Brain Res1984;56:523–31.
3.
GallagherJP. An electrophysiological investigation of the rat medial vestibular nucleus in vitro. In: CorreiaMJ, PerachioAA, eds. Contemporary Sensory Neurobiology. (Proceedings of the third symposium of the Galveston chapter of the Society for Neuroscience; May 14–15, 1984; Galveston, Tex.) New York: Alan R. Liss, 1985:293.
4.
YatesBJ, MillerAD, LucotJB. Physiological basis and pharmacology of motion sickness: An update. Brain Res Bull1998;47:395–406.
5.
MatsuokaI, DominoEF. Cholinergic mechanisms in the cat vestibular system. Neuropharmacology1975;14:201–10.
6.
MatsuokaI, ItoJ, TakahashiH, Experimental vestibular pharmacology: A minireview with special reference to neuroactive substances and antivertigo drugs. Acta Otolaryngol Suppl1984;419:62–70.
7.
WeinerDM, BrannMR. The distribution of a dopamine D2 receptor mRNA in rat brain. FEBS Lett1989;253:207–13.
8.
HulmeEC, BirdsallNJ, BuckleyNJ. Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol1990;30:633–73.
9.
PedigoNWJr, BrizzeeKR. Muscarinic cholinergic receptors in area postrema and brainstem areas regulating emesis. Brain Res Bull1985;14:169–77.
10.
LewisMR. Histamine H1 and H2 mechanisms may modulate motion sickness development. Aerospace Medical Association Abstract1987:A10.
11.
TakataniT, ItoJ, MatsuokaI, Effects of diphenhydramine iontophoretically applied onto neurons in the medial and lateral vestibular nuclei. Jpn J Pharmacol1983;33:557–61.
12.
OtsukaM, YanagisawaM.Does substance P act as a pain transmitter? Trends Pharmacol Sci1987;8:506–10.
13.
de WaeleC, MuhlethalerM, VidalPP. Neurochemistry of the central vestibular pathways. Brain Res Brain Res Rev1995;20:24–46.
14.
ZanniM, GiardinoL, ToschiL, Distribution of neurotransmitters, neuropeptides, and receptors in the vestibular nuclei complex of the rat: An immunocytochemical, in situ hybridization and quantitative receptor autoradiographic study. Brain Res Bull1995;36:443–52.
15.
KirstenEB, SharmaJN. Characteristics and response differences to iontophoretically applied norepinephrine, D-amphetamine, and acetylcholine on neurons in the medial and lateral vestibular nuclei of the cat. Brain Res1976;112:77–90.
16.
KandelER, SchwartzJH, JessellTM, eds. Principles of Neural Science. 3rd ed. New York: Elsevier, 1991.
17.
RobinsonDA. Adaptive gain control of vestibuloocular reflex by the cerebellum. J Neurophysiol1976;39:954–69.
18.
SingletonGT. Relationships of the cerebellar nodulus to vestibular function: A study of the effects of nodulectomy on habituation. Laryngoscope1967;77:1579–1619.
ItoM.Recent advances in cerebellar physiology and pathology. Adv Neurol1978;21:59–84.
21.
LlinasR, WaltonK, HillmanDE, SoteloC.Inferior olive: Its role in motor learning. Science1975;190:1230–1.
22.
BorisonHL, WangSC. Functional localization of central coordinating mechanism for emesis in cat. J Neurophysiol1949;12:305–13.
23.
HasegawaS, TakedaN, MoritaM, Vestibular, central and gastral triggering of emesis: A study on individual susceptibility in rats. Acta Otolaryngol1992;112:927–31.
24.
BalohRW. Dizziness, Hearing Loss, and Tinnitus. Philadelphia: F.A. Davis, 1998.
25.
Palermo-NetoJ.Dopaminergic systems. Dopaminergic receptors. Psychiatr Clin North Am1997;20:705–21.
26.
MissaleC, NashSR, RobinsonSW, Dopamine receptors: From structure to function. Physiol Rev1998;78:189–225.
27.
JaarsmaD, RuigrokTJ, CaffeR, Cholinergic innervation and receptors in the cerebellum. Prog Brain Res1997;114:67–96.
28.
Russo-NeustadtA, CotmanCW. Adrenergic receptors in Alzheimer's disease brain: Selective increases in the cerebella of aggressive patients. J Neurosci1997;17:5573–80.
29.
PompeianoO.Noradrenergic influences on the cerebellar cortex: Effects on vestibular reflexes under basic and adaptive conditions. Otolaryngol Head Neck Surg1998;119:93–105.
30.
BongianniF, MutoloD, CarfiM, PantaleoT.Area postrema glutamate receptors mediate respiratory and gastric responses in the rabbit. Neuroreport1998;9:2057–62.
31.
CummingP, GjeddeA, VincentS.Histamine H3 binding sites in rat brain: Localization in the nucleus of the solitary tract. Brain Res1994;641:198–202.
32.
QianM, JohnsonAE, KallstromL, Cholecystokinin, dopamine D2 and N-mefhyl-D-aspartate binding sites in the nucleus of the solitary tract of the rat: Possible relationship to ingestive behavior. Neuroscience1997;77:1077–89.
33.
HydeTM, KnableMB, MurrayAM. Distribution of dopamine D1–D4 receptor subtypes in human dorsal vagal complex. Synapse1996;24:224–32.
34.
YoshikawaT, YoshidaN, HosokiK.Involvement of dopamine D3 receptors in the area postrema in R(+)-7-OH-DPAT-induced emesis in the ferret. Eur J Pharmacol1996;301:143–9.
35.
PaakkariI, KarppanenH, PaakkariP.Site and mode of action of Clonidine in the central nervous system. Acta Med Scand Suppl1976;602:106–9.
36.
AvoliM, HwaG, LouvelJ, Functional and pharmacological properties of GABA-mediated inhibition in the human neocortex. Can J Physiol Pharmacol1997;75:526–34.
37.
YabeT, de WaeleC, SerafinM, Medial vestibular nucleus in the guinea-pig: Histaminergic receptors. II. An in vitro study. Exp Brain Res1993;93:249–58.