We examined the space and temporal distributions of the rotatory evoked brain electrical activity patterns (brain electrical activity mapping of vestibular evoked potentials [VestEP]) in humans. We performed a longitudinal scalp line analysis, transversal line analysis, and clockwise/counterclockwise rotation analysis of the VestEP principal components in 75 healthy persons aged 22 to 30 years (mean: 25.8). We found that the shortest VestEP latencies and the highest amplitudes were registered in a relatively distinct cortical area that is covered by the transversal electrode line T3-C3-Cz-C4-T4, in accordance with the 10/20 international electrode scheme. This area corresponds to the posterior part of the frontal lobe (Brodmann's area 4, the primary motor field of the isocortex) and the anterior parts of the cerebral parietal lobe (the gyrus postcentralis, which corresponds to the primary somatosensory fields, Brodmann's areas 1, 2, and 3). In this article, we discuss a method of investigation that exhibits the VestEPs, and we review one normal case and three typical cases of pathologic VestEPs.
References
1.
WalzlEM, MountcastleVB. Projections of the vestibular nerve to cerebral cortex of cat. Am J Physiol1949;159:595–8.
2.
MickleWA, AdesHW. A composite sensory projections area in the cerebral cortex of cat. Am J Physiol1952;170:682–9.
3.
KornhuberHH, FredricksonJM, FiggeU.Die kortikale Projektion der vestibularen Afferenz beim Rhesusaffen. Pflugers Arch1965;283:20–5.
4.
PenfieldW, JasperH.Epilepsy and the Functional Anatomy of the Human Brain. Boston: Little, Brown, 1954.
5.
FredricksonJM, ScheidP, FiggeU, KornhuberHH. Vestibular nerve projection to the cerebral cortex of the rhesus monkey. Exp Brain Res1966;2:318–27.
6.
BrodmannK.Vergleichende Lokalisationslehre der Grosshirnrinde. Leipzig: Barth, 1909.
7.
GacekRR. Anatomy of the central vestibular system. In: JacklerRK, BrackmannDE, eds. Neurotology. St. Louis: Mosby, 1994;41–58.
8.
WachsmuthW, von LanzT.Praktische Anatomic Ein Lehr- und Hilfsbuch der anatomischen Grundlagen aerztlichen Handelns. Erster Band-Erster Teil. Kopf. Teil A. Uebergeordnete Systeme. Berlin: Springer-Verlag, 1985:483–9.
9.
ClaussenC, SchneiderD, KolchevC.On the functional state of central vestibular structures in monoaural symptomatic tinnitus patients (BEAM-VbEP Study). Int Tinnitus J1995;1:5–12.
10.
ConstantinescuL, SchneiderD, ClaussenC.Vestibular evoked potentials in two patients with bilateral vestibular loss. Int Tinnitus J1996;2:45–57.
11.
SchneiderD, KolchevC, ConstantinescuL, ClaussenC.Vestibular evoked potentials (VestEP) and brain electrical activity mapping—A test of vestibular function—A review (1990–1996). Int Tinnitus J1996;2:27–43.
12.
RauberA, KopschF.Anatomie des Menschen, Band III, Nervensystem, Sinnesorgane. In: LeonhardtH, TonduryG, ZillesK, eds. Anatomie des Menschen. Stuttgart: Georg Thieme Verlag, 1987:273–6.
13.
SchwarzDW, TomlinsonRD. Physiology of the vestibular system. In: JacklerRK, BrackmannDE, eds. Neurotology. St. Louis: Mosby, 1994:59–98.
14.
ZillesK, RehkamperG.Funktionelle Neuroanatomie. Lehrbuch und Atlas. Berlin: Springer, 1993;228–41.
15.
DuffyFH, IyerVG, SurwilloWW. Clinical Electroencephalography and Topographic Brain Mapping: Technology and Practice. New York: Springer-Verlag, 1989.
16.
ClaussenCF. Neurotology. Sensory system analysis by evoked potentials. Medical Focus1986;2:2–8.
17.
ClaussenCF, KolchevC, SchneiderD, HahnA.Neurootological brain electrical activity mapping in tinnitus patients. In: AranJM, DaumanR, eds. Proceedings of the 4th International Tinnitus Seminar; Bordeaux, France; 1991, Amsterdam: Kugler Publications, 1992:351–5.
18.
ClaussenCF, KolchevC, BertoraGO, BergmannJM. Los potenciales evocados equilibriometricos por medio del BEAM — y su importancia en el diagnostics) y tratamiento de los pacientes con vertigo. In: Sacristan-AlonsoR.Bartual-PastorJ, eds. Compensacion Vestibular y Vertigos. XV Congreso Nacional de la Sociedad Espanola de ORL y Patologia Cervicofacial. Madrid: Gonzales, 1993:27–46.
19.
ClaussenCF, KolchevC.Vestibular evoked potentials. In: KaufmanArenberg I, ed. Dizziness and Balance Disorders: An Interdisciplinary Approach to Diagnosis. Treatment, and Rehabilitation. Amsterdam: Kugler Publications, 1993:413–26.
20.
ClaussenCF, KolchevC, BertoraG, Vestibular late evoked potentials, a complementary tool for neuro-otological topodiagnostics in dizzy patients. In: ClaussenCF, SakataE, ItohA, eds. Vertigo, Nausea, Tinnitus, and Hearing Loss in Central and Peripheral Vestibular Diseases. Proceedings of the XXIInd Annual Meeting of the International Neuro-otologic and Equilibriometric Society; Hakone, Japan; April 6–9, 1995. Amsterdam: Elsevier, 1995:231–4.
21.
KolchevC, SchneiderD, ClaussenCF, RohatgiMS. Vestibular evoked response in humans. In: ClaussenCF, KirtaneMV, SchneiderD, eds. Conservative versus Surgical Treatment of Sensorineural Hearing Loss, Tinnitus, Vertigo, and Nausea. Proceedings of the XVIIIth Scientific Meeting of the Neurootological and Equilibriometric Society; Budapest; April 4–7, 1991. Hamburg: Medicin + Pharmacie, 1992:91–4.
22.
KolchevC, SchneiderD, GiannakopoulosN.Brain Mapping of the Rotational Evoked Potential in Tinnitus Patients. Proceedings of the IInd International Meeting in Audiology for the Mediterranean Countries and the VIth Panhellenic Meeting in Otolaryngology; Thessaloniki, Greece; Oct. 5–9, 1991. Thessaloniki: Gamma. 1991:195–6.
23.
KolchevC, ClaussenCF, SchneiderD.Vestibular evoked potentials in central vertigo cases. In: ClaussenCF, KirtaneMV, SchneiderD, eds. Vertigo, Nausea, and Hypoacusia due to Central Disequilibrium—Visual Mechanisms in Balance Control. Proceedings of the XIXth Scientific Meeting of the Neurootological and Equilibriometric Society; Bad Kissingen, Germany; March 27–29, 1992. Hamburg: Medicin + Pharmacie, 1994:529–36.
24.
KolchevC, ClaussenCF, SchneiderD, Extended normative data on vestibular evoked potentials displayed by brain electrical activity mapping. In: ClaussenCF, KirtaneMV, SchneiderD, eds. Drugs and Chemicals in Neurootology—Experimental Neurootology. Proceedings of the XXth Scientific Meeting of the Neurootological and Equilibriometric Society; Linkoping, Sweden; June 3–6, 1993. Hamburg: Medicin+Pharmacie, 1995:195–200.
25.
KolchevC, ClaussenCF, SchneiderD.Vestibular evoked potentials in patients suffering from central dysequilibrium. In: ClaussenCF, KirtaneMV, SchneiderD, eds. Drugs and Chemicals in Neurootology—Experimental Neurootology. Proceedings of the XXth Scientific Meeting of the Neurootological and Equilibriometric Society; Linkoping, Sweden; June 3–6, 1993. Hamburg: Medicin + Pharmacie, 1995:201–6.
26.
DonchinE, CallawayE, CooperR, Publication Criteria for Studies of Evoked Potentials (EP) in Man. Report of a Committee. Attention, Voluntary Contraction, and Event-Related Cerebral Potentials. Progress in Clinical Neurophysiology. Basel: Karger, 1975.
27.
NiedermeyerE, Lopes daSilva F.Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, Munich: Urban and Schwarzenberg, 1987:940.
28.
BalohRW, FurmanJM. Modern vestibular function testing. West J Med1989;150:59–67.
29.
BohmerA, HennV, LehmannD.Vestibular evoked potentials in the awake rhesus monkey. Adv Otorhinolaryngol1983;30:54–7.
30.
BummP, JohanssenHS, SprengM, WiegandHP. [Slow evoked cortical potentials to rotary stimulation in man]. Arztl Forsch1970;24:59–62.
31.
CoaleFS, WalshEJ, McGeeJ, KonradHR. Vestibular evoked potentials in response to direct unilateral mechanical stimulation. Otolaryngol Head Neck Surg1989;100:177–86.
32.
DurrantJD, FurmanJM. Long-latency rotational evoked potentials in subjects with and without bilateral vestibular loss. Electroencephalogr Clin Neurophysiol1988;71:251–6.
33.
ElidanJ, LanghoferL, HonrubiaV.The neural generators of the vestibular evoked response. Brain Res1987;423:385–90.
34.
ElidanJ, LanghoferL, HonrubiaV.Recording of short-latency vestibular evoked potentials induced by acceleration impulses in experimental animals: Current status of the method and its applications. Electroencephalogr Clin Neurophysiol1987;68:58–69.
35.
ElidanJ, LeibnerE, FreemanS, Short and middle latency vestibular evoked responses to acceleration in man. Electroencephalogr Clin Neurophysiol1991;80:140–5.
36.
ElidanJ, SohmerH, NizanM.Recording of short latency vestibular evoked potentials to acceleration in rats by means of skin electrodes. Electroencephalogr Clin Neurophysiol1982;53:501–5.
37.
FredricksonJM, KornhuberHH, SchwarzDW. Cortical Projection of the Vestibular Nerve. Handbook of Sensory Physiology. Berlin: Springer, 1974:565–82.
38.
HamidMA, HughesGB. Vestibular evoked potentials in man: An overview. Otolaryngol Head Neck Surg1986;95:347–8.
39.
HofferberthB.Evoked potentials to rotatory stimulation. Preliminary results. Acta Otolaryngol Suppl1984;406:134–6.
40.
HoodJD. Vestibular and optokinetic evoked potentials. Acta Otolaryngol1983;95:589–93.
41.
HoodJD, KayanA.Observations upon the evoked responses to natural vestibular stimulation. Electroencephalogr Clin Neurophysiol1985;62:266–76.
42.
SalamyJ, PotvinA, JonesK, LandrethJ.Cortical evoked responses to labyrinthine stimulation in man. Psychophysiology1975;12:55–61.
43.
SpeckmannEJ, ElgerCE. Introduction to the Neurophysiological Basis of the EEG and DC Potentials. In: NiedermeyerE.Lopes daSilva F.Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Munich: Urban and Schwarzenberg, 1987:1–3.
44.
ConstantinescuL, SchneiderD, ClaussenCF. The influence of betahistine on the vestibular evoked potentials in patients with peripheral vestibular disorders. In: RibariO, HirschbergA, eds. Proceedings of the 3rd European Congress of the European Federation of Oto-Rhino-Laryngological Societies; Budapest; June 1996. Bologna: Monduzzi Editore, 1996:95–8.
