Cutaneous metastatic disease is a prognostically important diagnosis. We report the case of a 64-year-old man who had an uncommon histologic type of lung cancer—a large cell undifferentiated carcinoma, which was metastatic to the skin of the nose. The relative frequency of cutaneous metastasis is similar to that of primary cancers. Cutaneous disease as the first sign of metastasis is most often seen in cancer of the lung. However, its appearance as a large tumor on the nose, which was observed in this case, is unusual.
References
1.
CamielM.R., AronB.S., AlexanderL.L.Metastases to palm, sole, nailbed, nose, face and scalp from unsuspected carcinoma of the lung. Cancer1969; 23: 214–20.
2.
SchwartzR.A.Cutaneous metastatic disease. J Am Acad Dermatol1995; 33: 161–82.
3.
SchwartzR.A.Histopathologic aspects of cutaneous metastatic disease. J Am Acad Dermatol1995; 33: 649–57.
4.
LeuF.Les métastases cutanées des cancers viscéraux: Thèse présentée à la Faculté de Médecine de l'Université de Lausanne pour l'obtention du grade de docteur en médecine.Lausanne: Imprimerie Held SA, 1964.
5.
LeuF., DelacrétazJ.Les métastases cutanées des cancers viscéraux. Rev Med Suisse Romande1966; 86: 596–601.
6.
de Souza SittartJ.A., CriadoP.R., Ivanov GomesM.Metastases cutaneas de carcinomas internos. Medicina Cutánea Ibero-Latino-Americana1995; 23: 11–4.
7.
BrownsteinM.H., HelwigE.B.Patterns of cutaneous metastasis. Arch Dermatol1972; 105: 862–8.
8.
BrownsteinM.H., HelwigE.B.Metastatic tumors of the skin. Cancer1972; 29: 1298–307.
9.
BrownsteinM.H., HelwigE.B.Spread of tumors to the skin. Arch Dermatol1973; 107: 80–6.
10.
AbramsH.L., SpiroR., GoldsteinN.Metastases in carcinoma: Analysis of 1000 autopsied cases. Cancer1950; 3: 74–85.
11.
WojcieszekZ.Przerzuty raka do skóry. Pol Tyg Lek1967; 22: 1118–9.
12.
SchwartzR.A., RubensteinD.J., RaventosA., LambertW.C.Inflammatory metastatic carcinoma of the parotid. Arch Dermatol1984; 120: 796–7.
13.
ReingoldI.M.Cutaneous metastases from internal carcinoma. Cancer1966; 19: 162–8.
14.
McWhorterJ.E., CloudA.W.Malignant tumors and their metastases: A summary of the necropsies on eight hundred sixty-five cases performed at the Bellevue Hospital of New York. Ann Surg1930; 92: 434–43.
15.
SuzukiN.Multiple skin metastases from cancer of internal organs. J Cancer Res1918; 3: 357–88.
16.
GatesO.Cutaneous metastases of malignant disease. Am J Cancer1937; 30: 718–30.
17.
SpencerP.S., HelmT.N.Skin metastases in cancer patients. Cutis1987; 39: 119–21.
18.
LookingbillD.P., SpanglerN., HelmK.F.Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patients. J Am Acad Dermatol1993; 29: 228–36.
19.
LookingbillD.P., SpanglerN., SextonF.M.Skin involvement as the presenting sign of internal carcinoma: A retrospective study of 7316 cancer patients. J Am Acad Dermatol1990; 22: 19–26.
20.
RosenT.Cutaneous metastases. Med Clin North Am1980; 64: 885–900.
21.
Ask-UpmarkE.On the location of malignant metastases with special regard to the behaviour of the primary malignant tumours of the lung. Acta Pathol Microbiol Scand1932; 9: 239–48.
22.
BradyL.W., O'NeillE.A., FarberS.H.Unusual sites of metastases. Semin Oncol1977; 4: 59–64.
23.
LambertW.C., SchwartzR.A.Metastasis [editorial]. J Am Acad Dermatol1992; 27: 131–3.
24.
SchwartzR.A., RubensteinD.J., RaventosA., LambertW.C.Inflammatory metastatic carcinoma of the parotid. Arch Dermatol1984; 120: 796–7.
25.
KanskyA., Balic-WinterA., Markovic-GlamocakM.Metastatic carcinoma of the skin (erysipelas carcinomatosum). Acta Derm Venereol Alpina Panonica et Adriatica1993; 1: 88–91.
ChenK.T.Malignant mesothelioma presenting as Sister Joseph's nodule. Am J Dermatopathol1991; 13: 300–3.
39.
QuecedoE., FebrerI., Martinez-EscribanoJ.A.Tumoral seeding after pericardiocentesis in a patient with a pulmonary adenocarcinoma. J Am Acad Dermatol1994; 31: 496–7.
