Introduction: Cigarette smoking is a leading cause of preventable death. Methods: Long and short `impediment profilers' (LIPs and SIPs, respectively) addressing nicotine addiction, depression, anxiety, stress, chemical dependency, weight control, and household smoking were developed and applied in a pilot smoking cessation study to tailor treatment. Results: Quit rate 72 hours after the target quit date was 50%; at 8 and 12 weeks it was 61% and 39%, respectively. The LIP identified fewer impediments than the SIP. Conclusions: Impediment profiling for tailored smoking cessation intervention is associated with high initial quit rates and warrants further study.
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