RiordanJR, RommensJM, KeremB-SIdentification of the cystic fibrosis gene: cloning and characterization of complementary DNA.Science1989; 245: 1066–73.
2.
WelshMJ. Abnormal regulation of ion channels in cystic fibrosis epithelia.FASEB J1990; 4: 2718–25.
3.
DorinJR, DickinsonP, AltonE.W.F.W.Cystic fibrosis in the mouse by targeted insertional mutagenesis.Nature1992; 359: 211–5.
4.
RatcliffR, EvansMJ, CuthbertAWProduction of a severe cystic fibrosis mutation in mice by gene targeting.Nature Gen1993; 4: 35–41.
5.
SnouwaertJN, BrigmanKK, LatourAMAn animal model for cystic fibrosis made by gene targeting.Science1992; 257: 1083–8.
6.
O'NealWK, HastyP, McCrayPBA severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.Hum Mol Genet1993; 2: 1561–9.
7.
AltonE.W.F.W., MiddletonPG, CaplenNJNon-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice.Nature Genet1993; 5: 135–42.
8.
HydeSC, GillDR, HigginsCFCorrection of the ion transport defect in cystic fibrosis transgenic mice by gene therapy.Nature1993; 362: 250–5.
9.
MiddletonPG, CaplenNJ, GaoXNasal application of the cationic liposome DC-Chol: DOPE dose not alter ion transport, lung function or bacterial growth.Eur Resp J1994; 7: 422–5.
10.
MiddletonPG, GeddesDM, AltonE.W.F.W.. Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium.Eur Resp J1994; 7: 2050–6.
11.
CaplenNJ, KinradeE, ChakeraAGene therapy for cystic fibrosis in humans by liposome mediated DNA transfer: the production of resources and the regulatory processGene Ther1994; 2: 1–9.
12.
GaoXA, HuangL.A novel cationic liposome reagent for efficient transfection of mammalian cells.Biochem Biophys Res Commun1991; 179: 280–5.
13.
CaplenNJ, AltonE.W.F.W., MiddletonPGLiposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.Nature Med1995; 1: 39–46.
14.
ZabnerJ, CoutureLA, GregoryRJ, GrahamSM, SmithAE, WelshMJ. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with CF.Cell1993; 75: 207–16.
15.
CrystalRG, McElvanyNG, RosenfeldMAdministration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis.Nature Genet1994; 8: 42–51.