Nitric Oxide 9 Years On

Furchgott R.F. , Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373–6.

Palmer R.M. , Ferrige A.G. , Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–6.

Rapoport R.M. , Draznin M.B. , Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983; 306: 174–6.

Bloch K.D. , Wolfram J.R. , Brown D.M. Three members of the nitricoxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics 1995; 27: 526–30.

Marsden P.A. , Heng H.H. , Scherer S.W. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 1993; 268: 17478–88.

Nadaud S. , Bonnardeaux A. , Lathrop M. , Soubrier F. Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun 1994; 198: 1027–33.

White K.A. , Marietta M.A. Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry 1992; 31: 6627–31.

Stuehr D.J. , Gross S.S. , Sakuma I. , Levi R. , Nathan C.F. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Expl Med 1989; 169: 1011–20.

Cunha F.Q. , Moncada S. , Liew F.Y. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem Biophys Res Commun 1992; 182: 1155–9

Liew F.Y. , Millott S. , Li Y. , Lelchuk R. , Chan W.L. , Ziltener H. Macrophage activation by interferon-gamma from host-protective T cells is inhibited by interleukin (IL)3 and IL4 produced by disease-promoting T cells in leishmaniasis. Eur J Immunol 1989; 19: 1227–32.

Huang P.L. , Huang Z. , Mashimo H. , Bloch K.D. , Moskowitz M.A. , Bevan J.A. Hypertension in mice lacking the gene for endothelial nitric oxide synthase [see comments]. Nature 1995; 377: 239–42.

Shaul P.W. , Smart E.J. , Robinson L.J. , German Z. , Yuhanna I.S. , Ying Y. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 1996; 271: 6518–22.

Williams D. , Vallance P. , Spencer J. , Neild G. , Imms F. Nitric oxide mediated dilatation in human pregnancy. Am J Physiol (in press)

Radomski M.W. , Palmer R.M. , Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987; 148: 1482–9.

Chowienczyk P.J. , Watts G.F. , Cockcroft J.R. , Ritter J.M. Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolemia. Lancet 1992; 340: 1430–2.

Calver A. , Collier J. , Moncada S. , Vallancc P. Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypert 1993; 10: 1025–31.

Calver A. , Collier J. , Vallance P. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 1992; 90: 2548–54.

Girerd X.J. , Hirsch A.T. , Cooke J.P. , Dzau V.J. , Creager M.A. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circulation Res 1990; 67: 1301–8.

Candipan R.C. , Wang B.Y. , Buitrago R. , Tsao P.S. , Cooke J.P. Regression or progression. Dependency on vascular nitric oxide. Arterioscler Thromb Vasc Biol 1996; 16: 44–50.

MacAllister R.J. , Whitley G.S. , Vallance P. Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int 1994; 45: 737–42.

Ignarro L.J. , Bush P.A. , Buga G.M. , Wood K.S. , Fukuto J.M. , Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990; 170: 843–50.

Wright C.E. , Rees D.D. , Moncada S. Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 1992; 26: 48–57.

Petros A. , Bennett D. , Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991; 338: 1557–8.

Balligand J.L. , Kelly R.A. , Marsden P.A. , Smith T.W. , Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci USA 1993; 90: 347–51.

Lewis N.P. , Tsao P.S. , Rickenbacher P.R. , Xue C. , Johns R.A. , Haywood G.A. Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. Circulation 1996; 93: 720–9.

Gaston B. , Reilly J. , Drazen J.M. , Fackler J. , Ramdey P. , Arnelle D. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci USA 1993; 90: 10957–61.

Kharitonov S.A. , Yates D. , Robbins R.A. , Logan Sinclair R. , Shinebourne E.A. , Barnes P.J. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343: 133–5.

Mearin F. , Mourelle M. , Guarner F. , Salas A. , Riveros Moreno V. , Moncada S. Patients with achalasia lack nitric oxide synthase in the gastro-oesophageal junction. Eur J Clin Invest 1993; 23: 724–8.

Huang P.L. , Dawson T.M. , Bredt D.S. , Snyder S.H. , Fishman M.C. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993; 75: 1273–86.

Vanderwinden J.M. , Maillcux P. , Schiffmann S.N. , Vanderhaeghen J.J. , De Laet M.H. Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis [published erratum appears in N Engl J Med 1992; 327: 1252] N Engl J Med 1992;327: 511-15

Ferreira S.H. , Moncada S. , Van J.R. Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biol 1971; 231: 237–9.

Geller D.A. , Freeswick P.D. , Nguyen D. , Nussler A.K. , Di Silvio M. , Shapiro R.A. Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response. Arch Surg 1994; 129: 165–71.

Irikura K. , Huang P.L. , Ma J. , Lee W.S. , Dalkara T. , Fishman M.C. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc Natl Acad Sci USA 1995; 92: 6823–7.