Advances in the Understanding of the Cause of Parkinson's Disease

Gibb WRG Lees AJ . The relevance of the Lewy body in the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745–52.

Fearnley JM Lees AJ . Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991;114:2283–301.

Dexter DT Jenner P Schapira AHV Marsden CD . Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. Ann Neurol 1992;32:S94–100.

Good PF Olanow CW Perl DP . Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease. A LAMMA study. Brain Res 1992;593:343–6.

Kastner A Hirsch EC Lejeune O Javoy-Agid F Rascol O Agid Y . Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? J Neurochem 1992;59:1080–9.

Olanow CW . An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol 1992;32:S2–9.

Singer TP Ramsay RR . Biochemical reactions leading to parkinsonian symptoms elicited by MPTP. In: Nagatsu T Fisher A Yoshida M , eds. Basic, Clinical and Therapeutic Aspects of Alzheimer's and Parkinson's Disease. New York: Plenum Press, 1990:219–25.

Cleeter MJW Cooper JM Schapira AHV . Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 1992;58:786–9.

Schapira AHV Mann VM Cooper JM Krige D Jenner P Marsden CD . Mitochondrial function in Parkinson's disease. Ann Neurol 1992;32:S116–24.

Hartley A Cooper JM Schapira AHV . Iron induced oxidative stress and mitochondrial dysfunction: relevance to Parkinson's disease. Brain Res 1993;627:349–53.

McGeer PL Itagaki S Akiyama H McGeer EG . Rate of cell death in Parkinsonism indicates active neuropathological process. Ann Neurol 1988;24:574–6.

Jenner P Dexter DT Sian J Schapira AHV Marsden CD . Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. Ann Neurol 1992;32:S82–7.

Mithöfer K Sandy MS Smith MT Di Monte D . Mitochondrial poisons cause depletion of reduced glutathione in isolated hepatocytes. Arch Biochem Biophys 1992;295:132–6.

Ward CD Duvoisin RC Ince SE Nutt JD Eldridge R Calne DB . Parkinson's disease in 65 pairs of twins and in a set of quadruplets. Neurology 1983;33:815–24.

Marsden CD . Parkinson's disease in twins. J Neurol Neurosurg Psychiatry 1987;50:105–6.

Golbe LI Di Iorio G Bonavita V Miller DC Duvoisin RC . A large kindred with autosomal dominant Parkinson's disease. Ann Neurol 1990;27:276–82.

Koller W Vetere-Overfield B Gray C Alexander C Chin T Dolezal J Hassanein R Tanner C . Environmental risk factors in Parkinson's disease. Neurology 1990;40:1218–21.

Armstrong M Daly AK Cholerton S Batement DN Idle JR . Mutant debrisoquine hydroxylation genes in Parkinson's disease. Lancet 1992;339:1017–18.

Steventon GB Heafield MTE Waring RH Williams AC . Xenobiotic metabolism in Parkinson's disease. Neurology 1989;39:883–7.

Suzuki K Mizuno Y Yoshida M . Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline. Biochem Biophys Res Commun 1989;162:1541–5.

Sayre LM Wang F Arora PK Riachi NJ Harik SI Hoppel CL . Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances. J Neurochem 1990;57:2106–15.