The prevalence of several paraneoplastic syndromes associated with ovarian cancer was determined from a clinicopathological study of 908 patients with primary ovarian malignancy in the North East Thames Region. The diversity and rarity of these manifestations are great and the explanation for them is difficult. Circumstantial evidence suggests that in some cases an autoimmune phenomenon is the most plausible cause.
HudsonCN. A review of immunological aspects of gynaecological malignancy. Br J Obstet Gynaecol1979;86:154–8.
2.
BeilbyJOWHomeCHWMilneGDParkinsonC. Alpha- fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. J Clin Pathol1979;32:455–61.
3.
BennettRMGinsbergMHThoussenS. Carcinomatous polyarteritis. The presenting symptom of an ovarian tumor and association with a platelet activating factor. Arthritis Rheum1976;19:953–8.
4.
WhitehouseJMA. Circulating antibodies in human malignant disease. Br J Cancer1973;28(Suppl 1):170.
5.
GerberMAKofflerDCohenCJ. Circulating antibodies in patients with ovarian carcinoma. Gynecol Oncol1977;5:228–32.
6.
LevinL. Host defences in ovarian cancer: Immunological considerations. In: HudsonCN, ed. Ovarian Cancer. Oxford: University Press, 1985:141.
7.
PoultonTACrowtherMEHayFCNinehamLT. Immune complexes in ovarian cancer. Lancet1978;ii:72–3.
8.
HoytREHamiltonJF. Ovarian cancer associated with the nephrotic syndrome. Obstet Gynecol1987;70:513–14.
9.
CroftBWilkinsonM. The incidence of carcinomatous neuropathy with special reference to lung and breast carcinoma. In: BrainWRNorrisF, eds. The remote effects of cancer on the nervous system. New York: Grune and Stratton, 1964:44–54.
10.
HallDJDyerMLParkerJCjr. Ovarian cancer complicated by cerebellar degeneration: A paraneoplastic syndrome. Gynecol Oncol1985;21:240–6.
11.
HetzelDJStanhopeCRO'NeillBPLennonVA. Gynecologic cancer in patients with subacute cerebellar degeneration predicted by anti-Purkinje cell antibodies and limited in metastatic volume. Mayo Clin Proc1990;65:1558–63.
12.
LoweDGShepherdJH. Enough evidence to operate? (editorial)Lancet1991;337:1066–7.
13.
ChamberlainMJWhitakerSRF. Hashimoto's disease, dermatomyositis and ovarian carcinoma. Lancet1963;i:1398–400.
14.
AdamsonASLittlewoodTJPostonGJHowsJMWolfeJN. Malignancy presenting as peripheral venous gangrene. J R Soc Med1988;81:609–10.
15.
HendersonPH. Multiple migratory thrombophlebitis associated with ovarian carcinoma. Am J Obstet Gynecol1955;70:452–3.
16.
MenziesDN. Two further cases of erythrocytosis secondary to fibromyomata. Proc R Soc Med1965;58:239.
17.
HammondDWinnickS. Paraneoplastic erythrocytosis and ectopic erythropoietins. Ann N Y Acad Sci1974;230:219–27.
18.
PetersWAAndersenWAThorntonWNjr. Dermatomyositis and co-existent ovarian cancer. A review of the compounding clinical problems. Gynecol Oncol1983;15:444–6.
19.
MedsgerTADixonJAGarwoodVF. Palmar fasciitis and polyarthritis associated with ovarian carcinoma. Ann Int Med1982;96:424–31.
20.
HaynesHACurthHO. Acanthosis nigricans. In: FitzpatrickTB, ed. Dermatology in General Medicine, 2nd edn.New York: McGraw Hill, 1979:1348.
21.
DingleyERMartenRH. Adenocarcinoma of the ovary presenting as acanthosis nigricans. J Obstet Gynaecol Br Cwlth1957;64:898–900.
22.
ParsonsVRigbyB. Cushing's syndrome associated with adenocarcinoma of the ovary. Lancet1958;ii:992–4.
23.
BollenECLamersCBJansenJBLarrsonLIJoostenHJ. Zollinger-Ellison syndrome due to a gastrin-producing ovarian cystadenocarcinoma. Br J Surg1981;68:776–7.
24.
AllanSGLockhartSPLeonardRCSmythJF. Paraneoplastic hypercalcaemia in ovarian carcinoma. Br J Med1984;228:1714–15.
25.
O'NeillRTMikutaJJ. Hypoglycemia associated with serous cystadenocarcinoma of the ovary. Obstet Gynecol1970;35:287–9.
26.
BrownHLaneM. Cushing's and malignant carcinoid syndromes from ovarian neoplasms. Arch Int Med1965;115:490–4.
27.
HayakawaTKameyaAMizunoRNodaAKondoTHirabayashiN. Hyperamylasemia with papillary serous cystadenocarcinoma of the ovary. Cancer1984;54:1662–5.
28.
TaraszewskiRRosmanPMKnightCACloneyDJ. Small cell carcinoma of the ovary. Gynecol Oncol1991;41:149–51.
29.
SkrabanckPMcParthinJPowellD. Tumor hypercalcemia and “ectopic hyperparathyroidism”. Medicine1980;59:262–82.
30.
BoyerMFriedlanderMBannatynePAtkinsonK. Hypercalcemia in association with mucinous cystadenocarcinoma of the ovary: A case report. Gynecologic Oncol1989;35:387–90.
31.
JosseRGWilsonDRHeerscheJNMillsJRMurrayTM. Hypercalcaemia with ovarian carcinoma: Evidence of a pathogenetic role for prostaglandins. Cancer1981;48:1233–41.
32.
KimWBockmanRLemosLLewisJLjr. Hypercalcemia associated with epidermal carcinoma in ovarian cystic teratoma. Obstet Gynecol1981;57:81S–5S.
33.
CocconiGCeciGJuvarraGMinopoliMRCocchiTFiacadoriFLechiABoniP. Successful treatment of subacute cerebellar degeneration in ovarian carcinoma with plasmapheresis. A case report. Cancer1985;56:2318–20.
34.
LevinLMcHardyJEPoultonTACurlingOMHudsonCN. Tumour associated immunity and immuno-competence in ovarian cancer. Br J Obstet Gynaecol1976;83:393–9.
35.
LevinLMcHardyJECurlingOMHudsonCN. Tumour antigenicity in ovarian cancer. Br J Cancer1975;32:152–9.
