GoodridgeD.M.G., ShorvonS.D.Epileptic seizures in a population of 6000: II: treatment and prognosis. Br Med J1983; 287: 645–7
2.
DamM., RichensA.Fifty years of phenytoin. International Congress and Symposium Series, No. 120. London: Royal Society of Medicine, 1987
3.
ChadwickD.Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders. Am J Med1988; 84(Suppl 1A): 6
4.
ChadwickD., ReynoldsE.H.When does epilepsy need treatment? Starting and stopping medication. Br Med J1985; 290: 1885–8
5.
ReynoldsE.H., ShorvonS.D.Monotherapy or polytherapy for epilepsy?Epilepsia1981; 22: 1–10
6.
ChadwickD.Overuse of monitoring of blood concentrations of antiepileptic drugs. Br Med J1987; 294: 723–4
7.
AnnegersJ.F., HauserW.A., ElvebackL.R.Remission of seizures and relapse in patients with epilepsy. Epilepsia1979; 20: 729–37
8.
PorterR.J.Antiepileptic drugs: efficacy and inadequacy. In: MeldrumB.S., PorterR.J., eds. New antiepileptic drugs.London: John Libbey, 1986: 3–15
9.
JacksonJ.H.On the anatomical, physiological and pathological investigation of epilepsies. West Riding Lunatic Asylum Medical Reports, 1873: 315
10.
BernadoL.A., PedleyT.A.Cellular mechanisms of focal epileptogenesis. In: MeldrumB.S., PedleyT.A., eds. Recent advances in epilepsy.New York: Raven Press, 1985: 1–19
11.
PrinceD.Neuronal events underlying focal epileptiform potentials. In: WiesserH.G., SpeckmannE.J., EngelJ., eds. The epileptic focus.London: John Libbey, 1989: 17–26
12.
WongR.K.S., PrinceD.A.Participation of calcium spikes during intrinsic burst firing in hippocampal neurons. Brain Res1978; 159: 385–90
13.
MeldrumB.S.Epilepsy and GABA-mediated inhibition. Int Rev Neurobiol1975; 17: 1–36
14.
ChadwickD.New therapeutic horizons in epilepsy. In: KennardC., ed. Recent advances in neurology, vol. 7. Edinburgh: Churchill-Livingstone, 1990 (in press)
15.
OlsenR.W.The GABA postsynaptic membrane receptor ionophone complex: site of action of convulsant and anticonvulsant drugs. Molec Cell Biochemist1981; 39: 261–79
16.
ChapmanA.G., KeaneP.E., MeldrumB.S., SimiandJ., VerniresJ.C.Mechanism of action of valproate. Prog Neurobiol1982; 19: 315–59
17.
MeldrumB.S.Is epilepsy a disorder of excitatory transmission? In: TrimbleM.R., ReynoldsE.H., eds.What is epilepsy? Edinburgh: Churchill Livingstone, 1986: 293–302
DaviesJ., EvansR.H., SmithD.A.S., WatkinsJ.C.Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous system. Comp Biochem Physiol1982; 72C: 211–24
20.
HerrlingP.L., MorrisR., SaltT.E.Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones. J Physiol1983; 339: 207–22
21.
TroupinA.S., MendinsJ.R., ChengF., RisingerM.W.MK801. In: MeldrumB.S., PorterR.J., eds. New anticonvulsant drugsLondon: John Libbey, 1986: 191–202
22.
MeldrumB.S., PorterR.J.New antiepileptic drugs.London: John Libbey, 1986
23.
JungM.J., LippertB., MetcalfB.W., BohlenP., SchechterP.J.Gamma-vinyl GABA (4-amino-hex-5-enoic acid), a new selective inhibitor of GABA-T: effects on brain GABA metabolism in mice. J Neurochem1977; 29: 797–802
24.
GroveJ., SchechterP.J., TellG.Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebro-spinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-ecoic-acid). Life Sci1981; 28: 2431–39
25.
ButlerW.H., FordG.P., NewberneJ.W.A study of the effects of vigabatrin on the central nervous system and retina of Sprague Dawley and Lister-hooded rats. Toxicol Pathol1987; 15: 143–8
JohnR.A., RimmerE.M., WilliamsJ., ColeG., FowlerL.J., RichensA.Micro-vacuolation in rat brains after long-term administration of GABA-transaminase inhibitors. Biochem Pharmacol1987; 36: 1467–73
28.
WormsP., DepoortereH., DurandA., MorselliP.L., LloydK.G., BartholiniG.Gamma-aminobutyric acid (GABA) receptor stimulation. I. Neuropharmacological profiles of progabide (SL 76 002) and SL 75 102, with emphasis on their anticonvulsant spectra. J Pharmacol Exp Ther1982; 220: 660–71
29.
MorselliP.L., BartholiniG., LloydK.G.Progabide. In: MeldrumB.S., PorterR.J., eds. New antiepileptic drugs.London: John Libbey, 1986: 237–53
30.
CrawfordP., ChadwickD.A comparative study of progabide, valproate and placebo as add-on therapy in patients with refractory epilepsy. J Neurol Neurosurg Psychiatry1986; 49: 1251–7
31.
LeppikI.E.A controlled study of progabide in partial seizures. Neurology1987; 37: 963–8
32.
CoquelinJ.P., KrallR., BossiL., MuschB., MorselliP.L.Drug safety profile of progabide. In: BartholiniG., FriedmannJ.C., LangerS.Z., MorselliP.L., eds. Epilepsy and GABA receptor agonists: basic and therapeutic research.New York: Raven Press, 1985: 431–40
BinnieC.D., Van Emde BoasW., LandG.S., MeijerJ.W.A., OverwegJ., Van WieringenA.Preliminary single-dose studies of a potential new antiepileptic drug, lamotrigine (BW430C) in epileptic patients. Br J Clin Pharmacol1985; 20: 285
40.
JawadS., OxleyJ.R., YuenW.C., RichensA.Reduction of interictal electroencephalographic spikes by lamotrigine in epileptic patients. Br J Clin Pharmacol1985; 20: 287
41.
JawadS., RichensA., GoodwinG., YuenW.C.Controlled trial of Lamotrigine for refractory partial seizures. Epilepsia1989; 30: 356–63